The treatment of elderly patients with aggressive non-Hodgkin's lymphomas: Feasibility and efficacy of an intensive multidrug regimen

Leukemia and Lymphoma

Volumn 22, Issue 5-6, 1996, Pages 483-493

  Bertini, M ^a   Freilone, R ^a   Vitolo, U ^a   Botto, B ^a   Ciotti, R ^b   Cinieri, S ^c   Di Nota, A ^d   Di Vito, F ^e   Levis, A ^f   Orsucci, L ^a   Pini, M ⁱ   Rota Scalabrini, D ^g   Todeschini, G ^h   Resegotti, L ^a  

^a MOLINETTE HOSPITAL   (Italy)

^b TREVIGLIO HOSPITAL   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

^d SAN CARLO HOSPITAL   (Italy)

^e Ospedale Regionale   (Italy)

^f C Arrigo Children's Hospital   (Italy)

^g MAURIZIANO HOSPITAL   (Italy)

^h UNIVERSITY OF VERONA   (Italy)

ⁱ Ospedale Civile   (Italy)

Author keywords

Elderly patients; Lymphoma; rG CSF

Indexed keywords

BLEOMYCIN; CYCLOPHOSPHAMIDE; EPIRUBICIN; ETOPOSIDE; LACTATE DEHYDROGENASE; PREDNISONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; VINBLASTINE;

AGED; ANEMIA; ARTICLE; BONE MARROW METASTASIS; CANCER COMBINATION CHEMOTHERAPY; CANCER REGRESSION; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONSTIPATION; DRUG EFFICACY; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; INFECTION; INTRAVENOUS DRUG ADMINISTRATION; LACTATE DEHYDROGENASE BLOOD LEVEL; LARGE CELL LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; NEUROTOXICITY; NEUTROPENIA; NONHODGKIN LYMPHOMA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROGNOSIS; SEPSIS; THROMBOCYTOPENIA;

EID: 16044372936     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609054787     Document Type: Article

References (37)

1. Barnes, N., Cartwright, R. A., O'Brien, C., Richards, I. D. G., Roberts, B., Bird, C. C. (1986) Rising incidence of lymphoide malignancies. True or false? British J. Cancer, 53, 393-8.
2. Carbone, A., Volper, R., Gloghin, A. et al. (1990) NHL in elderly: Pathological feature et presentation Cancer, 66, 1991-6.
3. Costantini, A., Crosignani, P., Zanetti, R., Vineis, P. (1992) Incidence of NHL in Italy J. Natl. Cancer Institute, 84, 1277-8.
4. The non Hodgkin's lymphoma Classification project: National Cancer Institute-sponsore study of classification of non Hodgkin lymphoma. Summary and description of a working formulation for clinical usage. (1982) Cancer, 49, 2112-35.
5. Coiffier, Gisselbrecht, C., Bosly, A. et al. (1990) Treatment of aggressive lymphomas in patient older than 69 years. First interim report of a randomized study from GELA. Proceding of the Fourth International Conference on Malignant lymphom abstr 82.
6. Armitage, J. O. and Potter, J. F. (1984) Aggressive chempotherapy for diffuse histiocytic lymphoma in the elderly: increased complications of advancing age. J. Am. Geriatr. Soc., 32, 269-273.
7. Dixon, D. O., Neilan, B., Jones, S. E. et al. (1986) Effect of age on therapeutic outcome in advanced diffuse histiocytic lymphoma: The South Oncology Group experience. J. Clin. Oncol., 4, 295-305.
8. Solal-Celigny, P., Chaisang, P., Herrera, A. et al. (1987) Age as the main prognostic factor in adult aggressive non Hodgkin lymphoma. Am. J. Med., 83, 1075-9.
9. Vose, J. M., Armitage, J. O., Dennis, O. et al. (1993) The importance of age in survival of patients treated with chemotherapy for aggressive non Hodgkin's lymphoma. J. Clin. Oncol., 6, 1838-1844.
10. Shipp, M. (1993) A predictive model for aggressive lymphoma. In the International NHL prognostic factors project N.E.J.M., 329, 987-94.
11. Vitolo, U., Bertini, M., Brusamolino, E. et al. (1992) MACOP-B treatment in Diffuse Large Cell Lymphoma: Identification of prognostic groups in a Italian Multicenter Study J. Clin. Oncol., 6, 1838-1844.
12. Lipschitz, D. A., Uduba, K. B. (1985) Age and hemopoietic system. J. Am. Ger. Soc., 30, 448-54.
13. Pettengel, R., Gurney, H., Radford, J. et al. (1992) Granulocyte colony stimulating factor to prevent dose limiting neutropenia in NHL: a randomized controlled trial. Blood, 80, 1430-36.
14. Gerhartz, H. H., Engelhard, M., Brittinger, G. et al. (1992) Randomized double blind placebo - controlled phase III study of rh-GM-CSF as adjunction - treatment of aggressive NHL. Blood, 80, (10-suppl. 1) 73a.
15. Kaplan, E. L., Meier, P. (1985) Non parametric estimation from incomplete information. J. Am. Stat. Assoc., 53, 457-81.
16. Breslow, N. (1974) Covariance analysis of censored survival data. Biometrics, 30, 89-99.
17. Hryniuk, W. M., Bush, H. (1984) The importance of dose intensity in chemotherapy of metastatic breast cancer. J. Clin. Oncol., 6, 1838-1844.
18. Ballester, O., Moscinski, L. C., Morris, D. et al. (1992) Acute myelogenus leukemia in the elderly. JAGS, 40, 3-297.
19. Begg, C. B., Carbome, P. (1983) Clinical trials and drug toxicity in the elderly. The experience of ECOG. Cancer, 52, 1986-1992.
20. Begg, C. B., Cohen, L., Ellergon, J. et al. (1980) Are the elderly predisposed to toxicity from cancer chemotherapy? An investigation using data from the ECOG. Cancer Clinical Trial, 3, 369-374.
21. Sweetenham, J. W., William, C. J. (1987) Malignant lymphoma in the elderly. Balliere's Clin. Hematol, 1, 493-511.
22. Miller, B. R. (1985) Neurotoxicity and vincristine JAMA, 253, 2045.
23. Haas, C. D., Coltman, C. B., Gottlieb, A. J. et al. (1976) Phase II evolution of bleomycin: a SWOG study Cancer, 38, 8-12.
24. Radford, J. A., Whelan, J. S., Rohatiner, A. Z. S. et al. (1994) Weekly VAPEC-B chemotherapy for high grade NHL: results of treatment in 184 pts. Ann. of Oncol., 5/2, 147-51.
25. Miller, T. P. and Jones, S. E. (1983) Initial chemotherapy for clinically localized lymphomas of unfavorable histology Blood, 62, 413-18.
26. Grogan, L. N., Corbally, N., Dervan, P. A. et al. (1994) Comparable prognostic factors and survival in elderly patients with aggressive non Hodgkin's lymphoma treated with standard dose Adriamycin-based regimens. Ann. of Oncol., 5/2, 47-51.
27. Tirelli, U., Zagonel, V., Serraino, D. et al. (1988) Non-Hodgkin's lymphomas in 137 pts aged 70 years or older: a retrospective European Organization for research and treatment of Cancer lymphoma group study J. Clin. Oncol., 6, 1708-1713.
28. Tirelli, U., Zagonel, V., Errante, D. et al. (1992) A prospective study of a new combination chemotherapy regimen in patients older then 70 years with unfavorable non Hodgkin's lymphoma J. Clin. Oncol., 6, 228-236.
29. Salvagno, L., Contu, A., Bianco, A. el al. (1992) A combination of mitoxantrone, etoposide and prednisone in elderly patients with NHL Ann of Oncol., 3, 833-837.
30. O'Reilly, S. E., Klimo, P., Connors, J. M. (1992) Low dose ACOP-B and VABE: weekly chemotherapy for elderly patients with advanced stage diffuse large cell lymphoma J. Clin. Oncol., 10,2: 228-236.
31. O'Reilly, S. E., Connors, J. M. et al. (1993) In search of an optimal regimen for elderly patients with advanced stage diffuse large cell lymphoma: results of a phase II study of P/DOCE chemotherapy J. Clin. Oncol., 11, 2250-2257.
32. Martelli, M., Guglielmi, C., Coluzzi, S. et al. (1993) P-VABEC a prospective study of a new weekly chemotherapy regimen for elderly aggressive non Hodgkin's lymphoma. J. Clin. Oncol., 11, 2362-2369.
33. Crawford, J., Ozer, H., Stoller et al. (1991) Reduction by granulocyte colony-stimulating factor of fever and neitropenia induced by chemotherapy in pts small cell lung cancer. New Englan J. Med., 325, 164-170.
34. Lee, M., Segal, G. M., Bagby, G. C. (1989) The hemopoietic microinvoroment in the elderly. Defects in IL1 induced CSF expression in vivo Exp. Hematol., 17, 952-960.
35. Bessel, E. M., Coutts, A., Fletcher, J. et al. (1994) NHL in elderly patients: a phase II study of MCOP chemotherapy in patients aged 70 years and over with intermediate or high grade histology Europ. J. Cancer., 30a, 9, 1337.
36. Zinzani, P. L., Bendandi, M., Gherlinzoni, F. et al. (1993) VNCOP-B regimen in the treatment of high grade non Hodgkin's lymphoma in eldery Haematologica, 78, 378.
37. Zucca, E., Roggero, E., Pinotti, G. et al. (1995) Patterns of survival in mantle cell lymphoma Ann. of Oncol., 3, 257-262.