Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 817, Issue 2, 2005, Pages 247-253

  Creeke, Paul I ^a   Seal, Andrew J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

1 Methylnicotinamide; HPLC; Human; l Methyl 2 pyridone 5 carboxamide; Metabolism; Niacin; Spot sampling; Urine

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NEGATIVE IONS; ULTRAVIOLET DETECTORS;

1-HEPTANESULPHONIC ACID; 1-METHYL-2-PYRIDONE-5-CARBOXAMIDE; NIACIN METABOLITES 1-METHYLNICOTINAMIDE; TRIMETHYLAMINE;

METABOLITES;

1 METHYL 6 OXONICOTINAMIDE; 1 METHYLNICOTINAMIDE; AMIDE; CREATININE; METHANOL; NICOTINIC ACID; PHOSPHATE; POLYMER; SULFONIC ACID DERIVATIVE; TRIMETHYLAMINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PROCEDURES; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELUTION; HUMAN; NUTRITION; PH MEASUREMENT; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET RADIATION; URINALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; NIACIN; NIACINAMIDE; PYRIDONES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 15944403591     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2004.12.012     Document Type: Article

References (23)

1. T.W. Stone Prog. Neurobiol. 64 2001 185
2. WHO, The Management of Nutrition in Major Emergencies, WHO, Geneva, 2000.
3. J.C. Dillon, P. Malfait, G. Demaux, and C. Foldi-Hope Ann. Nutr. Metab. 36 1992 181
4. M.F. Murray Clin. Infect. Dis. 36 2003 453
5. E.L. Jacobson, P.U. Giacomoni, M.J. Roberts, G.T. Wondrak, and M.K. Jacobson J. Photochem. Photobiol. B 63 2001 141
6. H. Okamoto, A. Ishikawa, Y. Yoshitake, N. Kodama, M. Nishimuta, T. Fukuwatari, and K. Shibata Am. J. Clin. Nutr. 77 2003 406
7. H.E. Sauberlich Laboratory Tests for the Assessment of Nutritional Status second ed. 1999 CRC Press LLC Boca Raton, FL
8. D.J. De Lange, and C.P. Joubert Am. J. Clin. Nutr. 15 1964 169
9. M.E. Pullman, and S.P. Colowick J. Biol. Chem. 206 1954 121
10. J.R. Burns, and B. Finlavson Invest. Urol. 18 1980 167
11. M. Iwaki, E. Murakami, and K. Kakehi J. Chromatogr. B Biomed. Sci. Appl. 747 2000 229
12. E.G. Carter Am. J. Clin. Nutr. 36 1982 926
13. R.C. Terry, and M. Simon J. Chromatogr. 232 1982 261
14. W.P. Moore, C.H. Bolton, L. Downs, H.A. Gilmor, and E.A. Gale Biomed. Chromatogr. 14 2000 69
15. J.S. Sandhu, and D.R. Fraser Int. J. Vitam. Nutr. Res. 51 1981 139
16. K. Shibata, T. Kawada, and K. Iwai J. Chromatogr. 424 1988 23
17. K. Aoyama, K. Matsubara, K. Okada, S. Fukushima, K. Shimizu, S. Yamaguchi, T. Uezono, M. Satomi, N. Hayase, S. Ohta, H. Shiono, and S. Kobayashi J. Neural Transm. 107 2000 985
18. R.W. McKee, Y.A. Kang-Lee, M. Panaqua, and M.E. Swendseid J. Chromatogr. 230 1982 309
19. M.A. Kutnink, H. Vannucchi, and H.E. Sauberlich J. Liq. Chromatogr. 7 1984 969
20. R. Pumpo, G. Sarnelli, A. Spinella, G. Budillon, and R. Cuomo Am. J. Gastroenterol. 96 2001 1183
21. R.A. Jacob, M.E. Swendseid, R.W. McKee, C.S. Fu, and R.A. Clemens J. Nutr. 119 1989 591
22. C.S. Fu, M.E. Swendseid, RA. Jacob, and R.W. McKee J. Nutr. 119 1989 1949
23. J.G. Prinsloo, J.P. Du Plessis, H. Kruger, D.J. De Lange, and L.S. De Villiers Am. J. Clin. Nutr. 21 1968 98