Lessons of studies of breast-conserving therapy with and without whole-breast irradiation for patient selection for partial-breast irradiation

Seminars in Radiation Oncology

Volumn 15, Issue 2, 2005, Pages 123-132

  Recht, Abram ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; ESTROGEN RECEPTOR; FLUOROURACIL; METHOTREXATE; TAMOXIFEN;

AGE DISTRIBUTION; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RISK; CANCER SURGERY; CLINICAL TRIAL; CONSERVATIVE TREATMENT; FOLLOW UP; HUMAN; PATIENT SELECTION; PRIORITY JOURNAL; RADIATION DOSE; REVIEW; TREATMENT FAILURE; TUMOR VOLUME;

EID: 15944400681     PISSN: 10534296     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semradonc.2004.10.002     Document Type: Article

References (75)

1. A. Recht Breast carcinoma in situ and early-stage invasive cancers L.L. Gunderson J.E. Tepper Clinical Radiation Oncology 2000 Churchill Livingstone New York, NY 968 998
2. S.J. Schnitt, J.L. Connolly Processing and evaluation of breast excision specimens a clinically oriented approach Am J Clin Pathol 98 1992 125 137
3. C. Park, M. Mitsumori, A. Nixon Outcome at 8 years following breast-conserving surgery and radiation therapy for invasive breast cancer influence of margin status and systemic therapy on local recurrences J Clin Oncol 18 2000 1668 1675
4. A.C. Neuschatz, T. DiPetrillo, H. Safaii Long-term follow-up of a prospective policy of margin-directed radiation dose escalation in breast-conserving therapy Cancer 97 2003 30 39
5. N.S. Goldstein, L. Kestin, F. Vicini Factors associated with ipsilateral breast failure and distant metastases in patients with invasive breast carcinoma treated with breast-conserving therapyA clinicopathologic study of 607 neoplasms from 583 patients Am J Clin Pathol 120 2003 500 527
6. R.J. Santiago, L. Wu, E. Harris Fifteen-year results of breast-conserving surgery and definitive irradiation for stage I and II breast carcinoma the University of Pennsylvania experience Int J Radiat Oncol Biol Phys 58 2004 233 240
7. G. Freedman, B. Fowble, A. Hanlon Patients with early stage invasive cancer with close or positive margins treated with conservative surgery and radiation have an increased risk of breast recurrence that is delayed by adjuvant systemic therapy Int J Radiat Oncol Biol Phys 44 1999 1005 1015
8. M.C. Smitt, K. Nowels, R.W. Carlson Predictors of reexcision findings and recurrence after breast conservation Int J Radiat Oncol Biol Phys 57 2003 979 985
9. S.C. Renton, J.-C. Gazet, H.T. Ford The importance of the resection margin in conservative surgery for breast cancer Eur J Surg Oncol 22 1996 17 22
10. K. Valassiadou, J.F. Robertson Efficacy of breast conserving surgery without adjuvant radiotherapy for invasive breast cancer in the elderly Eur J Surg Oncol 28 2002 797 798 (abstr)
11. A.P. Forrest, H.J. Stewart, D. Everington Randomized controlled trial of conservation therapy for breast cancer 6-year analysis of the Scottish trial Lancet 348 1996 708 713
12. U. Veronesi, E. Marubini, L. Mariani Radiotherapy after breast-conserving surgery in small breast carcinoma long-term results of a randomized trial Ann Oncol 12 2001 997 1003
13. R.M. Clark, T. Whelan, M. Levine Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer an update J Natl Cancer Inst 88 1996 1659 1664
14. M. Lim, A.J. Nixon, R. Gelman A prospective study of conservative surgery (CS) alone without radiotherapy (RT) in selected patients with stage I breast cancer Breast Cancer Res Treat 57 1999 34 (abstr)
15. S.H. Lee, M.A. Chung, D. Chelmow Avoidance of adjuvant radiotherapy in selected patients with invasive breast cancer Ann Surg Oncol 11 2004 316 321
16. D.R. McCready, J.A. Chapman, W.M. Hanna Factors associated with local breast cancer recurrence after lumpectomy alone postmenopausal patients Ann Surg Oncol 7 2000 562 567
17. T. Nemoto, J.K. Patel, D. Rosner Factors affecting recurrence in lumpectomy without irradiation for breast cancer Cancer 67 1991 2079 2082
18. A.H. Cabral, M. Recine, J.C. Paramo Tubular carcinoma of the breast an institutional experience and review of the literature Breast J 9 2003 298 301
19. C.E. Leonard, K.A. Howell, H. Shapiro Excision alone for small tubular cancers of the breast Breast Cancer Res Treat 82 suppl 1 2003 S180 (abstr)
20. S.J. Schnitt, J. Hayman, R. Gelman A prospective study of conservative surgery alone in the treatment of selected patients with stage I breast cancer Cancer 77 1996 1094 1100
21. D.R. McCready, W. Hanna, H. Kahn Factors associated with local breast cancer recurrence after lumpectomy alone Ann Surg Oncol 3 1996 358 366
22. E.R. Fisher, R. Sass, B. Fisher Pathologic findings from the National Surgical Adjuvant Breast Project (protocol 6) II. Relation of local breast recurrence to multicentricity Cancer 57 1986 1717 1724
23. B. Fisher, S. Anderson, E. Fisher Significance of ipsilateral breast tumor recurrence after lumpectomy Lancet 338 1991 327 331
24. A. Recht Early breast cancer--when can radiotherapy be omitted? I.S. Fentiman Challenges in Breast Cancer 1999 Blackwell Science Oxford 139 154
25. B. Fisher, J. Bryant, J.J. Dignam Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less J Clin Oncol 20 2002 4141 4149
26. P. Zhou, A. Recht Young age and outcome for women with early stage invasive breast cancer Cancer 101 2004 1264 1274
27. D.E. Merkel, J. Skillings, H. Cramer DNA ploidy, S-phase fraction (SPF) and grade as predictors of local recurrence (LR) and survival after lumpectomy for node-negative breast cancer (NNBC) Proc Am Soc Clin Oncol 12 1993 74 (abstr)
28. B. Fisher, C. Redmond Lumpectomy for breast cancer an update of the NSABP experience J Natl Cancer Inst Monogr 11 1992 7 13
29. G. Martelli, D. Moglia, P. Boracchi Surgical resection plus tamoxifen as treatment of breast cancer in elderly patients a retrospective study Eur J Cancer 29A 1993 2080 2082
30. A.J. Nixon, D. Neuberg, D.F. Hayes Relationship of patient age to pathologic features of the tumor and prognosis for patients with Stage I or II breast cancer J Clin Oncol 12 1994 888 894
31. B. Fisher, C. Redmond Systemic therapy in node-negative patients updated findings from NSABP clinical trials J Natl Cancer Inst Monogr 11 1992 105 115
32. B. Fisher, D.L. Wickerham, C. Redmond Recent developments in the use of systemic adjuvant therapy for the treatment of breast cancer Semin Oncol 19 1992 263 277
33. B. Fisher, J. Dignam, E.P. Mamounas Sequential methotrexate and fluorouracil for the treatment of node-negative breast cancer patients with estrogen receptor-negative tumors eight-year results from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-13 and first report of findings from NSABP B-19 comparing methotrexate and fluorouracil with conventional cyclophosphamide, methotrexate, and fluorouracil J Clin Oncol 14 1996 1982 1992
34. B. Fisher, J. Dignam, J. Bryant Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors J Natl Cancer Inst 88 1996 1529 1542
35. L.E. Rutqvist, B. Cedermark, U. Glas Randomized trial of adjuvant tamoxifen in node negative postmenopausal breast cancer Acta Oncol 31 1992 265 270
36. V.F. Semiglazov, O.L. Chagunava, V.M. Moiseyenko Impact of adjuvant chemotherapy in conservative treatment of breast cancer T1-2N0M0 Eur J Cancer 32A suppl 2 1996 36 (abstr)
37. B. Fisher, J. Dignam, N. Wolmark Tamoxifen in treatment of intraductal breast cancer National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial Lancet 353 1999 1993 2000
38. B. Fowble, D.A. Fein, A.L. Hanlon The impact of tamoxifen on breast recurrence, cosmesis, complications, and survival in estrogen receptor-positive early-stage breast cancer Int J Radiat Oncol Biol Phys 35 1996 669 677
39. D.E. Wazer, J. Morr, J.K. Erban The effects of postirradiation treatment with tamoxifen on local control and cosmetic outcome in the conservatively treated breast Cancer 80 1997 732 740
40. M.N. Levine, M. Gent, W.M. Hryniuk A randomized trial comparing 12 weeks versus 36 weeks of adjuvant chemotherapy in stage II breast cancer J Clin Oncol 8 1990 1217 1225
41. K.-J. Winzer, R. Sauer, W. Sauerbrei Radiation therapy after breast-conserving surgery; first results of a randomised clinical trial in patients with low risk of recurrence Eur J Cancer 40 2004 998 1005
42. R. Blamey, U. Chetti, D. George Update of the BASO II trial of primary treatment of tumours of excellent prognosis EJC Supplements 2 2004 161 (abstr)
43. P.J. Froud, D. Mates, J.S. Jackson Effect of time interval between breast-conserving surgery and radiation therapy on ipsilateral breast recurrence Int J Radiat Oncol Biol Phys 46 2000 363 372
44. A. Recht, S.E. Come, I.C. Henderson The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer N Engl J Med 334 1996 1356 1361
45. J. Bellon, S.E. Come, R. Gelman Sequencing of chemotherapy and radiation therapy for patients with early stage breast cancer updated results of a prospective randomized trial Int J Radiat Oncol Biol Phys 51 suppl 1 2001 2 3 (abstr)
46. W.F. Hartsell, D.C. Recine, K.L. Griem Delaying the initiation of intact breast irradiation for patients with lymph node positive breast cancer increases the risk of local recurrence Cancer 76 1995 2497 2503
47. A. Recht Integration of systemic therapy and radiation therapy for patients with early-stage breast cancer treated with conservative surgery Clin Breast Cancer 4 2003 104 113
48. I.J. Das, C.-W. Cheng, D.A. Fein Patterns of dose variability in radiation prescription of breast cancer Radiother Oncol 44 1997 83 89
49. C.-W. Cheng, I.J. Das, W. Tang Dosimetric comparison of treatment planning systems in irradiation of breast with tangential fields Int J Radiat Oncol Biol Phys 38 1997 835 842
50. L.M. Chin, C.W. Cheng, R.L. Siddon Three-dimensional photon dose distributions with and without lung corrections for tangential breast intact treatments Int J Radiat Oncol Biol Phys 17 1989 1327 1335
51. B.A. Fraas, A.S. Lichter, D.L. McShan The influence of lung density corrections on treatment planning for primary breast cancer Int J Radiat Oncol Biol Phys 14 1988 179 190
52. L.J. Solin, J.C.H. Chu, M.R. Sontag Three-dimensional photon treatment planning of the intact breast Int J Radiat Oncol Biol Phys 21 1991 193 203
53. C.-W. Cheng, I.J. Das, S. Baldassarre The effect of the number of computed tomographic slices on dose distributions and evaluation of treatment planning systems for radiation therapy of the intact breast Int J Radiat Oncol Biol Phys 30 1994 183 195
54. T.A. Buchholz, E. Gurgoze, W.S. Bice Dosimetric analysis of intact breast irradiation in off-axis planes Int J Radiat Oncol Biol Phys 39 1997 261 267
55. P. Romestaing, Y. Lehingue, C. Carrie Role of a 10-Gy boost in the conservative treatment of early breast cancer results of a randomized clinical trial in Lyon, France J Clin Oncol 15 1997 963 968
56. P. Romestaing, Y. Lehingue, C. Delauney Role of a 10-Gy boost in the conservation treatment of early breast cancer results of a randomized clinical trial in Lyon, France Int J Radiat Oncol Biol Phys 51 suppl 1 2001 3 4 (abstr)
57. E. Tessier, M. Héry, A. Ramaioli Boost in conservative treatment 6 years results of randomized trial Breast Cancer Res Treat 50 1998 287 (abstr)
58. H. Bartelink, J.C. Horiot, P. Poortmans Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation N Engl J Med 345 2001 1378 1387
59. C. Polgár, J. Fodor, Z. Orosz Electron and high-dose-rate brachytherapy boost in the conservative treatment of stage I-II breast cancer first results of the randomized Budapest boost trial Strahlenther Onkol 178 2002 615 623
60. C. Vrieling, L. Collette, A. Fourquet Can patient-, treatment- and pathology-related characteristics explain the high local recurrence rate following breast-conserving therapy in young patients? Eur J Cancer 39 2003 932 944
61. W.F. Hartsell, C.A. Kelly, K.L. Griem Breast conserving therapy a boost dose of radiation therapy is not necessary when negative margins of excision are achieved Breast Cancer Res Treat 27 1993 190 (abstr)
62. R.D. Pezner, L.D. Wagman, J. Ben-Ezra Breast conservation therapy local tumor control in patients with pathologically clear margins who receive 5000 cGy breast irradiation without local boost Breast Cancer Res Treat 32 1994 261 267
63. M.C. Smitt, K.W. Nowels, M.J. Zdeblick The importance of the lumpectomy surgical margin status in long term results of breast conservation Cancer 76 1995 259 267
64. T. Whelan, R. MacKenzie, J. Julian Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer J Natl Cancer Inst 94 2002 1143 1150
65. G. Liljegren, L. Holmberg, J. Bergh 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer a randomized trial J Clin Oncol 17 1999 2326 2333
66. T. Gruenberger, M. Gorlitzer, M. Mittlboeck Adjuvant radiotherapy has no benefit after primary breast cancer treatment in selected postmenopausal patients Eur J Cancer 34 suppl 1 1998 S31 (abstr)
67. K. Holli, R. Saaristo, J. Isola Lumpectomy with or without postoperative radiotherapy for breast cancer with favourable prognostic features results of a randomized study Br J Cancer 84 2001 164 169
68. A. Fyles, L. Manchul, D. McCready A randomized trial of tamoxifen with or without breast irradiation in women over 50 years of age with T1/2 N0 disease Radiother Oncol 69 suppl 1 2003 S6 S7 (abstr)
69. K.S. Hughes, L. Schnaper, D. Berry Comparison of lumpectomy plus tamoxifen with and without radiotherapy (RT) In women 70 years of age or older who have clinical stage I, estrogen receptor positive (ER+) breast carcinoma Proc Am Soc Clin Oncol 37 2001 93 (abstr)
70. R.R. Kuske, J.S. Bolton, G. Fuhrman Wide volume brachytherapy alone for select breast cancers the ten year experience of the Ochsner Clinic Int J Radiat Oncol Biol Phys 48 suppl 3 2000 296 (abstr)
71. F.A. Vicini, K.L. Baglan, L.L. Kestin Accelerated treatment of breast cancer J Clin Oncol 19 2001 1993 2001
72. V.A. Palda, H.A. Llewellyn-Thomas, R.G. Mackenzie Breast cancer patients' attitudes about rationing postlumpectomy radiation therapy applicability of trade-off methods to policy-making J Clin Oncol 15 1997 3192 3200
73. J.A. Hayman, D.L. Fairclough, J.R. Harris Patient preferences concerning the trade-off between the risks and benefits of routine radiation therapy after conservative surgery for early-stage breast cancer J Clin Oncol 15 1997 1252 1260
74. F.A. Vicini, L. Kestin, P. Chen Limited-field radiation therapy in the management of early-stage breast cancer J Natl Cancer Inst 95 2003 1205 1210
75. W.W. Suh, L.J. Pierce, F.A. Vicini Comparing the cost of partial versus whole breast irradiation following breast conserving surgery for early-stage breast cancer Breast Cancer Res Treat 82 suppl 1 2003 S181 (abstr)