Clinical toxicology study of an herbal medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama®) in healthy volunteers

Phytotherapy Research

Volumn 19, Issue 1, 2005, Pages 54-57

  Oliveira, Celso H ^a,c   Moraes, Maria Elizabete A ^b   Moraes, Manoel O ^b   Bezerra, Fernando A F ^b   Abib, Eduardo ^a   De Nucci, Gilberto ^a  

^a Miguel Servet Clin Pharmacol Unit   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^c NONE   (Brazil)

Author keywords

Catuaba; Guarana; Herbal; Tonic

Indexed keywords

APHRODISIAC AGENT; CATUAMA; DIPYRONE; ERGOT DERIVATIVE; GINGER EXTRACT; HERBACEOUS AGENT; PARACETAMOL; PAULLINIA CUPANA EXTRACT; PLANT EXTRACT; PTYCHOPETALUM OLACOIDES EXTRACT; RANITIDINE; TRICHILIA CATIGUA EXTRACT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD ANALYSIS; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DEFECATION DISORDER; DIARRHEA; DRUG FORMULATION; ELECTROCARDIOGRAM; FECES COLOR; FEMALE; GINGER; HEADACHE; HEARTBURN; HUMAN; HUMAN EXPERIMENT; INSOMNIA; LABORATORY TEST; MALE; NORMAL HUMAN; PAULLINIA; PAULLINIA CUPANA; SEX DIFFERENCE; SOMNOLENCE; STOMACH PAIN; VOMITING;

ADULT; BLOOD CHEMICAL ANALYSIS; FEMALE; GINGER; HUMANS; MALE; MELIACEAE; OLACACEAE; PAULLINIA; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; REFERENCE VALUES;

CATUAMA; MELIACEAE; OLACACEAE; PAULLINIA CUPANA; PTYCHOPETALUM; PTYCHOPETALUM OLACOIDES; TRICHILIA; ZINGIBER OFFICINALE; ZINGIBERACEAE;

EID: 15944395720     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1484     Document Type: Article

References (16)

1. Accetturi C, Lewi DS, Lousana GB. 1997. Manual de Boas Práticas em Ensaios Clínicos. Universidade Federal de São Paulo - UNIFESP/EPM: São Paulo; 119-124.
2. Antunes E, Gordo WM, de Oliveira JF, Teixeira CE, Hyslop S, De Nucci G. 2001. The relaxation of isolated rabbit corpus cavernosum by the herbal medicine Catuama® and its constituents. Phytother Res 15: 416-421.
3. Blumenthal M, Busse WR, Goldberg A, et al. 1998. The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. American Botanical Council: Austin, TX; 138-139.
4. Bone ME, Wilkinson DJ, Young JR, McNeil J, Charlton S. 1990. Ginger root-a new antiemetic. The effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery. Anaesthesia 45: 669-671.
5. Bydlowski SP, D'Amico EA, Chamone DA. 1991. An aqueous extract of guarana (Paullinia cupana) decreases platelet thromboxane synthesis. Braz J Med Biol Res 24: 421-424.
6. Calixto JB, Cabrini DA. 1997. Herbal medicine Catuama induces endothelium-dependent and -independent vasorelaxant action on isolated vessels from rats, guinea-pigs and rabbits. Phytother Res 11: 32-38.
7. Charam I. 1987. Há açöes afrodisiácas nas plantas medicinais do Brasil? Folha Méd 94: 303-309.
8. Coimbra R. 1994. Manual de Fitoterapia. Editera Cejup, Belém, PA, 2nd edn, 84, 198.
9. Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. 1991. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 38: 19-24.
10. Galduroz JC, Carlini EA. 1994. Acute effects of the Paulinia cupana, 'Guarana' on the cognition of normal volunteers. Sao Paulo Med J 112: 607-611.
11. Galduróz JCF, Carlini EA. 1996. The effects of long-term administration of guarana on the cognition of normal, elderly volunteers. Sao Paulo Med J 114: 1073-1078.
12. Grontved A, Hentzer E. 1986. Vertigo-reducing effect of ginger root. A controlled clinical study. ORL J Otorhinolaryngol Relat Spec. 48: 282-286.
13. Mattei R, Dias RF, Espínola EB, Carlini EA, Barros SBM. 1998. Guarana (Paullinia cupana): toxic behavioral effects in laboratory animals and antioxidant activity in vitro. J Ethnopharmacol 60: 111-116.
14. Miura T, Tatara M, Nakamura K, Suzuki I. 1998. Effect of guarana on exercise in normal and epinephrine-induced glycogenolytic mice. Biol Pharm Bull 21: 646-648.
15. PDR. 2000. Physicians' Desk Reference for Herbal Medicines. Medical Economics Company 2nd edn, 376-378.
16. Vaz ZR, Mata LV, Calixto JB. 1997. Analgesic effect of the herbal medicine Catuama in thermal and chemical models of nociception in mice. Phytother Res 11: 101-106.