Stage conversion of Toxoplasma gondii RH parasites in mice by treatment with atovaquone and pyrrolidine dithiocarbamate

Microbes and Infection

Volumn 7, Issue 1, 2005, Pages 49-54

  Djurković Djaković, Olgica ^a   Nikolić, Aleksandra ^a   Bobić, Branko ^a   Klun, Ivana ^a   Aleksić, Anastasija ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Atovaquone; Brain cysts; Pyrrolidine dithiocarbamate; RH strain; Swiss Webster mice; Toxoplasma gondii

Indexed keywords

ATOVAQUONE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; PYRROLIDINE DITHIOCARBAMATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; BRAIN CYST; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DOSE RESPONSE; DRUG EFFECT; FEMALE; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PARASITE VIRULENCE; PRIORITY JOURNAL; SURVIVAL; TOXOPLASMA GONDII; TOXOPLASMOSIS; TREATMENT OUTCOME;

EID: 15944395691     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2004.09.016     Document Type: Article

References (32)

1. J.P. Dubey C.P. Beattie Toxoplasmosis of Animals and Man 1988 CRC Press Boca Raton
2. J.P. Dubey J.P. Kreier Parasitic Protozoa, vol. 3 1977 Academic Press New York 101 237
3. L.D. Sibley, and J.C. Boothroyd Virulent strains of Toxoplasma gondii comprise a single clonal lineage Nature 359 1992 82 85
4. D.K. Howe, and L.D. Sibley Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease J. Infect. Dis. 172 1995 1561 1566
5. A.B. Sabin Toxoplasmic encephalitis in children JAMA 116 1941 801 807
6. J.K. Frenkel, J.P. Dubey, and R.L. Hoff Loss of stages after continuous passage of Toxoplasma gondii and Besnoitia jellisoni J. Protozool. 23 1976 421 424
7. O. Villard, E. Candolfi, D.J.P. Ferguson, L. Marcellin, and T. Kien Loss of oral infectivity of tissue cysts of Toxoplasma gondii RH strain to outbred Swiss-Webster mice Int. J. Parasitol. 27 1997 1555 1559
8. O. Djurković-Djaković, A. Nikolić, B. Bobić, and I. Klun Combined effect of atovaquone and pyrrolidine dithiocarbamate in the treatment of acute murine toxoplasmosis Chemotherapy 50 2004 155 156
9. O. Djurković-Djaković, T. Nikolić, F. Robert-Gangneux, B. Bobić, and A. Nikolić Synergistic effect of clindamycin and atovaquone in acute murine toxoplasmosis Antimicrob. Agents Chemother. 43 1999 2240 2244
10. O. Djurković-Djaković, V. Milenković, A. Nikolić, B. Bobić, and J. Grujić Efficacy of atovaquone combined with clindamycin against murine infection with a cystogenic (Me49) strain of Toxoplasma gondii J. Antimicrob. Chemother. 50 2002 981 987
11. S.P. Bach, R. Chinery, S.T. O'Dwyer, C.S. Potten, R.J. Coffey, and A.J. Watson Pyrrolidine dithiocarbamate increases the therapeutic index of 5-fluorouracil in a mouse model Gastroenterology 118 2000 81 89
12. P.R.B. McMaster, K.G. Powers, J.F. Finerty, and M.N. Lunde The effect of two chlorinated lincomycin analogues against acute toxoplasmosis in mice Am. J. Trop. Med. Hyg. 22 1973 14 17
13. E.Y. Denkers T Lymphocyte-dependent effector mechanisms of immunity to Toxoplasma gondii Microbes Infect. 1 1999 699 708
14. G. Desmonts, and J.S. Remington Direct agglutination test for diagnosis of Toxoplasma infection: method for increasing sensitivity and specificity J. Clin. Microbiol. 11 1980 562 568
15. O. Djurković-Djaković, B. Bobić, A. Nikolić, and D. Vuković Murine susceptibility to Toxoplasma gondii tachyzoite infection Arch. Biol. Sci. 48 1996 31 35
16. O. Djurković-Djaković, and V. Milenković Murine model of drug-induced reactivation of Toxoplasma gondii Acta Protozool. 40 2001 99 106
17. W. Bohne, J. Heeseman, and U. Gross Coexistence of heterogeneous populations of Toxoplasma gondii parasites within parasitophorous vacuoles of murine macrophages as revealed by a bradyzoite-specific monoclonal antibody Parasitol. Res. 79 1993 485 487
18. D.K. Howe, and L.D. Sibley Toxoplasma gondii: analysis of different laboratory stocks of the RH strain reveals genetic heterogeneity Exp. Parasitol. 78 1994 242 245
19. Z.G. Guo, and A.M. Johnson Genetic characterization of Toxoplasma gondii strains by random amplified polymorphic DNA polymerase chain reaction Parasitology 111 1995 127 132
20. S. Mavin, A.W. Joss, J. Ball, and D.O. Ho-Yen Do Toxoplasma gondii RH strain tachyzoites evolve during continuous passage? J. Clin. Pathol. 57 2004 609 611
21. R.E. Lyons, R. McLeod, and C.W. Roberts Toxoplasma gondii tachyzoite-bradyzoite interconversion Trends Parasitol. 18 2002 198 201
22. M. Soete, B. Fortier, D. Camus, and J.F. Dubremetz Toxoplasma gondii: kinetics of bradyzoite-tachyzoite interconversion in vitro Exp. Parasitol. 76 1993 259 264
23. M. Soete, D. Camus, and J.F. Dubremetz Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain of Toxoplasma gondii in vitro Exp. Parasitol. 78 1994 361 370
24. W. Bohne, J. Heesemann, and U. Gross Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: a possible role for nitric oxide in triggering stage conversion Infect. Immun. 62 1994 1761 1767
25. L.M. Weiss, Y.F. Ma, P.M. Takvorian, H.B. Tanowitz, and M. Wittner Bradyzoite development in Toxoplasma gondii and the hsp70 stress response Infect. Immun. 66 1998 3295 3302
26. V. Lecomte, V. Chumpitazi, B. Pasquier, P. Ambroise-Thomas, and F. Santoro Brain-tissue cysts in rats infected with the RH strain of Toxoplasma gondii Parasitol. Res. 78 1992 267 269
27. G.S. Yap, T. Scharton-Kersten, D.J.P. Ferguson, D. Howe, Y. Suzuki, and A. Sher Partially protective vaccination permits the development of latency in a normally virulent strain of Toxoplasma gondii Infect. Immun. 66 1998 4382 4388
28. C. Mercier, D.K. Howe, D. Mordue, M. Lingnau, and L.D. Sibley Targeted disruption of the GRA2 locus in Toxoplasma gondii decreases acute virulence in mice Infect. Immun. 66 1998 4176 4182
29. E.R. Pfefferkorn, S.E. Borotz, and R.F. Nothnagel Mutants of Toxoplasma gondii resistant to atovaquone (566C80) or decoquinate J. Parasitol. 79 1993 559 564
30. F.G. Araujo, J. Huskinson, and J.S. Remington Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone, 566C80, against tachyzoites and tissue cysts of Toxoplasma gondii Antimicrob. Agents Chemother. 35 1991 293 299
31. D.J. Ferguson, J. Huskinson-Mark, F.G. Araujo, and J.S. Remington An ultrastructural study of the effect of the treatment with atovaquone in brains of mice chronically infected with the ME 49 strain of Toxoplasma gondii Int. J. Exp. Pathol. 75 1994 111 116
32. M. Camps, and J.C. Boothroyd Toxoplasma gondii: selective killing of extracellular parasites by oxidation using pyrrolidine dithiocarbamate Exp. Parasitol. 98 2001 206 214