Neovastat(Æ-941) inhibits the airway inflammation and hyperresponsiveness in a murine model of asthma

Journal of Microbiology

Volumn 43, Issue 1, 2005, Pages 11-16

  Lee, Sook Young ^a   Paik, Soon Young ^a   Chung, Su Mi ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Airway resistance; Asthma; Inflammation; Matrix metalloproteinase 9; Neovastat

Indexed keywords

AE 941; GELATINASE B; METHACHOLINE; OVALBUMIN; ANGIOGENESIS INHIBITOR; SHARK CARTILAGE EXTRACT AE 941; TISSUE EXTRACT; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BODY WEIGHT; CELL COUNT; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; INFLAMMATION; LUNG LAVAGE; MEASUREMENT; MOUSE; MOUSE STRAIN; NONHUMAN; ZYMOGRAPHY; AIRWAY RESISTANCE; ANIMAL; BAGG ALBINO MOUSE; BRONCHUS HYPERREACTIVITY; CARTILAGE; CHEMISTRY; DISEASE MODEL; DRUG ANTAGONISM; IMMUNOLOGY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

AIRWAY RESISTANCE; ANGIOGENESIS INHIBITORS; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CARTILAGE; DISEASE MODELS, ANIMAL; FEMALE; IMMUNIZATION; INFLAMMATION; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; OVALBUMIN; TISSUE EXTRACTS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 15944390514     PISSN: 12258873     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Adcock, I.M. 1996. Steroid resistance in asthma. Molecular mechanisms. Am. J. Respir. Crit. Care Med. 154, S58-61.
2. Béliveau, R., D. Gingras, E.A. Kruger, S. Lamy, P. Sirois, B. Simard, M.G. Sirois, L. Tranqui, F. Baffert, E. Beaulieu, V. Dimitriadou, M.C. Pepin, F. Courjal, I. Ricard, P. Poyet, P. Falardeau, W.D. Figg, and E. Dupont. 2002. The antiangiogenic agent neovastat (AE-941) inhibits vascular endothelial growth factor-mediated biological effects. Clin. Cancer Res. 8, 1242-1250.
3. Boivin, D., S. Gendron, Beaulieu, D. Gingras, and R. Béliveau. 2002. The Antiangiogenic Agent Neovastat (Æ-941) Induces Endothelial Cell Apoptosis. Molecular Cancer Therapeutics. 1, 795-802.
4. Castronovo, V., V. Dimitriadou, P. Savard, M. Rivière, and E. Dupont. 1999. Cartilage as a source of natural inhibitors of angiogenesis. Antiangiogenic Agents in Cancer Therapy, p. 175-83. Humana Press, Totowa, New Jersey.
5. Cho, J.Y., M. Miller, K.J. Baek, G. W. Han, J. Nayar, M. Rodriguez, S.Y. Lee, K. McElwain, S. McElwain, E. Raz, and D.H. Broide. 2004. Immunostimulatory DNA Inhibits Transforming Growth Factor-β Expression and Airway Remodeling. Am. J. Respir. Cell Mol. Biol. 30, 651-661.
6. Delcaux, C., C. Delacourt, M.P. d'Ortho, V. Boyer, C. Lafuma, and A. Harf. 1996. Role of gelatinase B and elastase in human polymorphonuclear neutrohil migration across basement membrane. Am. J. Respir. Cell Mol. Biol. 14, 288-295.
7. Dunnill, M.S. 1960. The pathology of asthma with special reference to changes in the bronchial mucosa. J. Clin. Patho. 13, 27-33.
8. Falardeau, P., P. Champagne, P. Poyet, C. Hariton, and E, Dupont. 2001. Æ-941 (Neovastat), a naturally occurring multifunctional anti-angiogenic product in Phase clinical trials. Semin. Oncol. 28, 620-625.
9. Gingras, D., A. Renaud, N. Mousseau, E. Beaulieu, Z. Kachra, and R. Béliveau. 2001. Matrix proteinase Inhibition by Æ-941, a multifunctional antiangiogenic compound. Anticancer Res. 21, 145-155.
10. Gingras, D., G. Batist, and R. Béliveau. 2001. Æ-941 (Neovastat®): A novel multifunctional antiangiogenic compound. Expert Rev. Anticancer Ther. 1, 341-347.
11. Jonathan, P.A. and T.H. Lee. 1992. The pathobiology of bronchial asthma. Adv. Immunol. 51, 323-329
12. Kelly, E.A. and N.N. Jarjour. 2003. Role of matrix metalloproteinases in asthma. Current Opinion in Pulmonary Medicine. 9, 28-33.
13. Kumagai, K., I. Ohno, S. Okada, Y. Ohkawara, S.K. uzuki, T Shinya, H. Nagase, K. Iwata, and S.K. hirato. 1999. Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma. J. Immunol. 162, 4212-4219.
14. Lee, Y.C., C.H. Song, H.B. Lee, J.L. Oh, Y.K. Rhee, H.S. Park, and G.Y. Koh. 2001. A murine model of toluene diisocyanate-induced asthma can be treated with matrix metalloproteinase inhibitor. J. Allergy Clin. Immunol. 108, 1021-1026.
15. Lee, K.S., S.M. Jin, H.J. Kim, and Y.C. Lee. 2003. Matrix metalloproteinase inhibitor regulates inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced asthma. J. Allergy Clin. Immunol. 111, 1278-1284.
16. Leppert, D., E. Waubant, R. Galardy, N.W. Bunnett, and S.L. Hauser. 1995. T cell gelatinases mediate basement membrane transmigration in vitro. J. Immunol. 154, 4379-4389.
17. Li, X. and J.W. Wilson. 1997. Increased vascularity of the bronchial mucosa in mild asthma. Am. J. Respir. Crit. Card. Med. 156, 229-233.
18. Lukacs, N.W. 2000. Migration of helper T-lymphocyte subsets into inflamed tissues. J. Allergy Clin. Immunol. 106, 264-269.
19. Mautino, G., N. Oliver, P. chanez, J. Bousquet, and F. Capony. 1997. Increased release of matrix metalloproteinase-9 in bronchoalveolar lavage fluid and by alveolar macrophgages of asthmatics. Am. J. Respir. Cell Mol. Biol. 17, 583-591.
20. Nagase, H. 1997. Activation mechanisms of matrix metalloproteinases. Biol. Chem. 378, 151-160.
21. Okada, S., H. Kita, T.J. George, G.J. Gleich, and K.M. Leiferman. 1997. Migration of eosinophil through basement membrane components in vitro:role of matrix metalloproteinase-9. Am. J. Respir. Cell Mol. Biol. 17, 519-528.
22. Stetler-Stevenson, W.G., H.C. Krutzsch, and L.A. Liotta. 1989. Tissue inhibitor of metalloproteinase (TIMP-2): A new member of the metalloproteinase family. J. Biol Chem. 264, 17374-17378
23. Sternlicht, M.D. and Z. Werb. 2001. How Matrix Metalloproteinases Regulate Cell Behavior. Ann. Rev. Cell Dev. Biol. 17, 463-516.
24. Stricklin, G. and H. Welgus. 1983. Human skin fibroblasts collagenase inhibitor : purification and biochemical characterization. J. Biol. Chem. 258, 12252-12258
25. Yang, H., S. Han, H. Kim, Y.M. Choi, K.J. Hwang, H.C. Kwon, S.K. Kim, and D.J. Cho. 2002. Expression of integrines, cyclooxygenases and matrix metalloproteinases in three-dimensional human endometrial cell culture system. Exp. Mol. Med. 34, 75-82.
26. Van Eerdewegh, P., R.D. Little, and J. Dupuis. 2002. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418, 426-430.
27. Warner, J.A., P. Julius, W. Luttmann, and C. Kroegel. 1997. Matrix metalloproteinases in bronchoalveolar lavage fluid following antigen challenge. Int. Arch. Allergy Immunol. 113, 318-320.