Strong expression of Bcl-2 in pigmented villonodular synovitis of the knee with aggressive clinical behaviour

Scandinavian Journal of Rheumatology

Volumn 34, Issue 1, 2005, Pages 68-70

  Berger, Irina ^a,c   Paessler, H H ^b   Weckauf, H ^a   Ehemann, V ^a   Helmchen, B ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ATOS KLINIK HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DNA; DNA FRAGMENT; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN P53;

ADULT; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CASE REPORT; CELL CYCLE PHASE; CELL PROLIFERATION; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DNA DETERMINATION; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNEE ARTHRITIS; KNEE RADIOGRAPHY; MALE; NICK END LABELING; PATHOPHYSIOLOGY; PIGMENTED VILLONODULAR SYNOVITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SYNOVIOCYTE; TISSUE LEVEL;

ADULT; APOPTOSIS; CASPASE 3; CASPASES; DNA FRAGMENTATION; FLOW CYTOMETRY; GENES, BCL-2; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MALE; SYNOVITIS, PIGMENTED VILLONODULAR; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 15944387439     PISSN: 03009742     EISSN: None     Source Type: Journal    
DOI: 10.1080/03009740410009823     Document Type: Article

References (10)

1. Neale SD, Kristelly R, Gundle R, Quinn JM, Athanasou NA. Giant cells in pigmented villonodular synovitis express an osteoclast phenotype. J Clin Pathol 1997;50:605-8.
2. Berger I, Ehemann V, Helmchen B, Penzel R, Weckauf H. Comparative analysis of cell populations involved in proliferative and inflammatory process in diffuse and localised pigmented villonodular synovitis. Histol Histopathol 2004; 19:687-92.
3. Weckauf H, Helmchen B, Hinz U, Meyer-Scholten, Otto HF, Berger I. Expression of cell cycle related gene products in different forms of primary versus recurrent PVNS. Cancer Lett 2004;210:111-8.
4. Yoshida W, Uzuki M, Kurose A, Yoshida M, Nishida J, Shimamura T. Cell characterization of mononuclear and giant cells constitutes pigmented villonodular synovitis. Hum Pathol 2003;34:65-73.
5. Wang HG, Reed JC. Mechanisms of Bcl-2 protein function. Histol Histopathol 1998;13:521-30.
6. Perka C, Labs K, Zippel H, Buttgereit F. Localized pigmented villonodular synovitis of the knee joint: neoplasma or reactive granuloma? A review of 18 cases. Rheumatol 2002;39:172-8.
7. Fassbender HG. Pathology and Pathobiology of Rheumatic Diseases. Berlin-Heidelberg-New York: Springer, 2002.
8. Ray RA, Morton CC, Lipinski KK, Corson JM, Fletcher JA. Cytogenetic evidence of clonality in a case of pigmented villonodular synovitis. Cancer 1991;67:121-5.
9. Layfeld LJ, Meloni-Ehring A, Liu K, Shepard R, Harrelson JM. Malignant giant cell tumor of synovium (malignant villonodular synovitis). Arch Pathol Lab Med 2000;124:1636-41.
10. Hockenbery DM, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348:334-6.