Determination of benzalkonium bromide homologues in disinfection products using high-performance liquid chromatography

Analytical Letters

Volumn 38, Issue 4, 2005, Pages 673-682

  Kuča, Kamil ^a,c   Bielavská, Marcela ^a   Cabal, Jiří ^a   Dohnal, Vlastimil ^b  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b MENDEL UNIVERSITY IN BRNO   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Benzalkonium; Disinfectants; Quaternary nitrogen; Reverse phase high performance liquid chromatography

Indexed keywords

ACETIC ACID; ACETONITRILE; BENZALKONIUM; BENZALKONIUM BROMIDE; DISINFECTANT AGENT; LITHIUM DERIVATIVE; LITHIUM PERCHLORATE; METHANOL; OCTANESULFONIC ACID; PERCHLORATE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; AQUEOUS SOLUTION; ARTICLE; QUANTITATIVE ASSAY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET RADIATION;

EID: 15944387420     PISSN: 00032719     EISSN: None     Source Type: Journal    
DOI: 10.1081/AL-200050326     Document Type: Article

References (16)

1. Altria, K.D., Elgey, J., and Howells, J.S. 1996. Validated capillary electrophoretic method for the quantitative analysis of histamine acid phosphate and/or benzalkonium chloride. J. Chromatogr. B, 686: 111-117.
2. Bernal, J.L., del Nozal, J., Martín, T., Diez-Masa, J.C., and Cifuentes, A. 1998. Quantitation of active ingredients and excipients in nasal sprays by high-performance liquid chromatography, capillary electrophoresis and UV spectroscopy. J. Chromatogr. A, 823: 423-431.
3. Bull, J.P., Serreqi, A.N., Chen, T., and Breuil, C. 1998. Development of an immunoassay for a quaternary ammonium compound, benzyldimethyldodecylammonium chloride. Wat. Res., 32: 3621-3630.
4. Elrod, L., Golich, T.G., and Morley, J.A. 1992. Determination of benzalkonium chlorides in eye care by high-performance liquid-chromatography and solid-phase extraction or online column switching. J. Chromatogr., 625: 362-367.
5. Gomez-Gomar, A., Gonzalez-Aubert, M.M., Garces-Torrents, J., and Costa-Segarra, J. 1990. Determination of benzalkonium chloride in aqueous opthalmic preparations by high-performance liquid-chromatography. J. Pharm. Biomed. Anal., 8: 871-876.
6. Halvax, J.J., Wiese, G., Arp, J.A., Vermeer, J.M.P., van Bennekom, W.P., and Bult, A. 1990. Rapid-determination of benzalkonium chloride in pharmaceutical preparations with flow-injection liquid-liquid-extraction. J. Pharm. Biomed. Anal., 8: 243-252.
7. Hou, Y.H., Wu, C.Y., and Ding, W.H. 2002. Development and validation of a capillary zone electrophoresis method for the determination of benzalkonium chlorides in ophthalmic solutions. J. Chromatogr. A, 976: 207-213.
8. ISO, Surfactant Active Agents. Detergents. 1972. Determination of Cationic-Active Matter: Direct Two Phase Titration Procedure, ISO 2871. Brussels: International Society Organisation.
9. Kuča, K., Kivala, M., and Dohnal, V. 2004. Method for the quaternization of N,N-dimethylbenzylamines with long chain N-alkylbromides. J. Appl. Biomed., 2: 195-198.
10. Kümerer, K., Eitel, A., Braun, U., Hubner, P., Daschner, F., Mascart, G., Milandri, M., Reinthaler, F., and Verhoef, J. 1997. Analysis of benzalkonium chloride in the effluent from European hospitals by solid-phase extraction and high-performance liquid chromatography with post-column ion-pairing and fluorescence detection. J. Chromatogr. A, 774: 281-286.
11. Merianos, J.J. 1991. Disinfection, Sterilization and Preservation; Block, S.S., ed.; Philadelphia, PA: Lea and Febiger, 225-255.
12. Meyer, R.C. 1980. Determination of benzalkonium chloride by reverse-phase high-pressure liquid-chromatography. J. Pharm. Sci., 69: 1148-1150.
13. Pinzauti, S., Mombagietti-Alberti, M., Moneti, G., la Porta, E., Coran, A.A., Vincieri, F.F., and Gratteri, P. 1989. Determination of benzalkonium chlorides in contact-lens solutions by positive-ion fast atom bombardment mass-spectrometry. J. Pharm. Biomed. Anal., 7: 1611-1616.
14. Prince, S.J., McLaury, H.J., Allen, L.V., and McLaury, P. 1999. Determination of benzalkonium chloride and its homologs: HPLC versus HPCE. J. Pharm. Biomed. Anal., 19: 877-882.
15. Santoni, G., Tonsini, A., Gratteri, P., Mura, P., Furianetto, S., and Pinzauti, S. 1993. Determination of atropine sulfate and benzalkonium chloride in eye drops by HPLC. Int. J. Pharm., 93: 239-243.
16. Suzuki, S., Nakamura, Y., Kaneko, M., Mori, K., and Watanabe, Y. 1989. Analysis of benzalkonium chlorides by gas-chromatography. J. Chromatogr., 463: 188-191.