Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 8, 2005, Pages 2087-2091

  Hirth, Bradford H ^a   Qiao, Shuang ^a   Cuff, Lisa M ^a   Cochran, Brian M ^a   Pregel, Marko J ^a   Gregory, Jill S ^a   Sneddon, Scott F ^a   Kane Jr , John L ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

CFTR; Cystic fibrosis

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; DIAMIDE; TETRAHYDROISOQUINOLINE DERIVATIVE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CHLORIDE TRANSPORT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG TRANSPORT; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 15944387059     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.02.041     Document Type: Article

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19. 3) δ 7.44-6.78 (m, 13H), 5.29 (t, J = 5.7 Hz, 0.6H), 5.18 (d, J = 17.9 Hz, 0.4H), 4.81-4.73 (m, 0.4H), 4.62-4.47 (m, 1.6H), 3.30-3.15 (m, 1.6H), 3.13-3.01 (m, 0.4H) ppm
20. 3) δ 8.81 (s, 0.8H), 7.54 (br s, 0.2H), 7.51-6.74 (m, 17H), 5.27 (t, J = 6.4 Hz, 0.8H), 5.16 (d, J = 16.5 Hz, 0.2H), 4.85-4.74 (m, 0.2H), 4.72-4.52 (m, 1H), 4.44-4.31 (m, 0.8H), 3.65-3.52 (m, 0.8H), 3.51-3.37 (m, 0.2H), 3.19-3.03 (m, 1H), 2.55 (t, J = 7.6 Hz, 2H), 1.64-1.49 (m, 2H), 1.35-1.12 (m, 8H), 0.87 (t, J = 6.6 Hz, 3H) ppm
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