An approach for measuring in vivo cerebral redox states using the oxidative conversion of dihydropyridine to pyridinium ion and the metabolic trapping principle

Free Radical Biology and Medicine

Volumn 38, Issue 9, 2005, Pages 1197-1205

  Okamura, Toshimitsu ^a,b   Kikuchi, Tatsuya ^a   Nagamine, Ayaka ^a,b   Fukushi, Kiyoshi ^a   Sekine, Toshikazu ^b   Arano, Yasushi ^b   Irie, Toshiaki ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Cerebral redox states; Dihyropyridine; Free radicals; Metabolic trapping principle; Oxidative stress; Pyridinium ion

Indexed keywords

DIHYDROPYRIDINE DERIVATIVE; GLUTATHIONE; IODINE DERIVATIVE; MALEIC ACID DIETHYL ESTER; N METHYL 3 (N' PHENYLCARBAMOYL) 1,4 DIHYDROPYRIDINE C 14; N METHYL 3 (N' PHENYLCARBAMOYL)PYRIDINIUM IODIDE C 14; N METHYL 3 ACETYL 1,4 DIHYDROPYRIDINE C 14; N METHYL 3 ACETYLPYRIDINIUM IODIDE C 14; N METHYL 3 CARBAMOYL 1,4 DIHYDROPYRIDINE C 14; N METHYL 3 CARBAMOYLPYRIDINIUM IODIDE C 14; N METHYL 3 CARBOMETHOXY 1,4 DIHYDROPYRIDINE C 14; N METHYL 3 CARBOMETHOXYPYRIDINIUM IODIDE C 14; N METHYL 3,5 DICARBOMETHOXY 1,4 DIHYDROPYRIDINE C 14; N METHYL 3,5 DICARBOMETHOXYPYRIDINIUM IODIDE C 14; PYRIDINIUM DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN METABOLISM; CONTROLLED STUDY; DRUG DESIGN; DRUG PENETRATION; DRUG SYNTHESIS; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RADIOACTIVITY;

EID: 15944369329     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.01.006     Document Type: Article

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