Prognostic significance of circumferential margin involvement in rectal adenocarcinoma treated with preoperative chemoradiotherapy and low anterior resection

Journal of Surgical Oncology

Volumn 90, Issue 1, 2005, Pages 20-25

  Luna Pèrez, Pedro ^a,b   Bustos Cholico, Efraín ^a   Alvarado, Isabel ^a   Maffuz, Antonio ^a   Rodríguez Ramírez, Saúl ^a   Gutiérrez De La Barrera, Marcos ^a   Labastida, Sonia ^a  

^a HOSPITAL DE ONCOLOGÍA   (Mexico)

^b NONE   (Mexico)

Author keywords

Complete response; Lymph node metastasis; Neo adjuvant chemoradiotherapy; Rectal cancer; Total mesorectal excision

Indexed keywords

FLUOROURACIL;

ADULT; ANUS SPHINCTER; ARTICLE; CALCULATION; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CAUSE OF DEATH; CONTROLLED STUDY; ECHOGRAPHY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RECTUM CARCINOMA; RECTUM RESECTION; RISK FACTOR; TREATMENT OUTCOME;

EID: 15944364705     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/jso.20232     Document Type: Article

References (15)

1. Dukes CE: Cancer of the rectum. An analysis of 1,000 cases. J Pathol Bacteriol 1940;50:527-539.
2. Quirke P, Durdey P, Dixon MF, et al.: Local recurrence of rectal adenocarcinoma due to inadequate surgical resection: Histopathological study of lateral tumour spread and surgical excision. Lancet 1986;2:996-999.
3. Cawthom SJ, Parums DV, Gibbs NM, et al.: Extent of mesorectal spread and involvement of lateral resection margin as prognostic factors after surgery for rectal cancer. Lancet 1990;335:1055-1059.
4. Kapiteijin E, Marijnen CAM, Nagtegaal ID, et al.: Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001;345:638-646.
5. Marijnen CAM, Nagtegaal ID, Kapiteijn E, et al.: Radiotherapy does not compensate for positive resection margins in rectal cancer patients: Report of a multicenter randomized trial. Int J Radiat Oncol Biol Phys 2003;55:1311-1320.
6. Andreola S, Leo E, Belli F, et al.: Manual dissection of adenocarcinoma of the lower third of the rectum specimens for detection of lymph nodes smaller than 5 mm. Cancer 1996;77:607-612.
7. Sánchez W, Luna-Pérez P, Alvarado I, et al.: Modified clearing technique to identify lymph node metastases in post-irradiated surgical specimens from rectal adenocarcinoma. Arch Med Res 1996;27:31-36.
8. Greene FL, Page DL, Fleming ID, et al.: editors. AJCC cancer staging manual, 6th edn. Colon and rectum. New York: Springer-Verlag, 2002. pp 113-124.
9. Hall NR, Finan PJ, Al-Jaberi T, et al.: Circumferential margin involvement after mesorectal excision of rectal cancer with curative intent: Predictor of survival but not local recurrence? Dis Colon Rectum 1998;41:979-983.
10. Nagtegaal ID, Marijnen CAM, Kranenbarg EK, et al.: Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma. Not one millimeter but two millimeters is the limit. Am J Surg Pathol 2002;26:350-357.
11. Adam IJ, Mohamdee MO, Martin IG, et al.: Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 1994;344:707-711.
12. Wibe A, Rendedal PR, Svenssson E, et al.: Prognostic significance of the circumferential resection margin following total mesorectal escisión for rectal cancer. Br J Surg 2002;89:327-334.
13. Birbeck KF, Macklin ChP, Tiffin NJ, et al.: Rates of circumferential resection margin involvement vary between surgeons and predict outcomes in rectal cancer surgery. Ann Surg 2002;235:449-457.
14. Ratto C, Ricci R, Rossi C, et al.: Mesorectal microfoci adversely affect the prognosis of patients with rectal cancer. Dis Colon Rectum 2002;45:733-743.
15. Brown G, Radcliffe AG, Newcombe RG, et al.: Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg 2003;90:355-364.