Concentrations and in vivo antibacterial activity of spiramycin and metronidazole in patients with periodontitis treated with high-dose metronidazole and the spiramycin/metronidazole combination

Journal of Antimicrobial Chemotherapy

Volumn 55, Issue 3, 2005, Pages 347-351

  Poulet, Pierre Pascal ^a   Duffaut, Danielle ^a   Barthet, Pierre ^a   Brumpt, Ivan ^b  

^a School of Medicine   (France)

^b SANOFI   (France)

Author keywords

Gingival crevice fluid; Oral anaerobic bacteria; Pharmacodynamics

Indexed keywords

METRONIDAZOLE; SPIRAMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG ERUPTION; DRUG MEGADOSE; ERADICATION THERAPY; FOLLOW UP; FUSOBACTERIUM; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEADACHE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; MULTICENTER STUDY; NAUSEA; NONHUMAN; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL;

DRUG THERAPY, COMBINATION; GINGIVAL CREVICULAR FLUID; HUMANS; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; PERIODONTITIS; PROSPECTIVE STUDIES; SPIRAMYCIN;

EID: 15844420666     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dki013     Document Type: Article

References (10)

1. Van Winkelhoff, A. J. & Van Der Reijden, W. A. (2000). Infections parodontales et implications thérapeutiques. Journal de Parodontologie & d'Implantologie orale 19, 141-56.
2. Laufer, J., Mignon, H. & Videau, D. (1973). L'association métronidazole - spiramycine. Concentrations et synergie in situ comparées aux CMI de la flore buccale. Revue de Stomatologie et de Chirurgie maxillo-faciale 74, 387-92.
3. Quee, T. C., Chan, E. C., Clark, C. et al. (1987). The role of adjunctive Rodogyl therapy in the treatment of advanced periodontal disease. A longitudinal clinical and microbiologic study. Journal of Periodontology 58, 594-601.
4. Loesche, W. J., Schmidt, E., Smith, W. J. et al. (1992). Effects of metronidazole on periodontal treatment needs. Journal of Periodontology 62, 247-57.
5. Rotzetter, P. A., Le Liboux, A., Pichard, E. et al. (1994). Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood. Journal of Clinical Periodontology 21, 595-600.
6. Poulet, P. P., Duffaut, D. & Lodter, J. P. (1999). Metronidazole susceptibility testing of anaerobic bacteria associated with periodontal disease. Journal of Clinical Periodontology 26 261-3.
7. Ximenez-Fyvie, L. A., Haffajee, A. D. & Socransky, S. S. (2000). Microbial composition of supra- and subgingival plaque in subjects with adult periodontitis. Journal of Clinical Periodontology 27, 722-32.
8. National Committee for Clinical Laboratory Standards. (1995). Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria: Approved Standard M11A3. NCCLS, Villanova, PA, USA.
9. Poulet, P. P., Duffaut, D., Lodter, J. P. et al. (1999). Etude in vitro de la sensibilité aux antibiotiques des bactéries anaérobies strictes associées à la maladie parodontale. Journal de Parodontologie et d'Implantologie orale 18, 251-8.
10. Dubreuil, L., Calvet, L., Rocques, C. et al. (2003). Etat de la. sensibilité aux antibiotiques des bactéries isolées lors d'infections odontogènes. Intérêt de l'association spiramycine-metronidazole. Médecine Buccale Chirurgie Buccale 9, 167-75.