Requirement of a corepressor for Dr1-mediated repression of transcription

Genes and Development

Volumn 10, Issue 8, 1996, Pages 1033-1048

  Mermelstein, Fred ^a   Yeung, Kam ^a   Cao, Jun ^a   Inostroza, Juan A ^a   Erdjument Bromage, Hediye ^b   Eagelson, Kathie ^c   Landsman, David ^d   Levitt, Pat ^c   Tempst, Paul ^b   Reinberg, Danny ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

corepression of transcription; Dr1 mediated repression; HeLa cells; heterodimer formation

Indexed keywords

ARTICLE; GENE REPRESSION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; TATA BOX;

EID: 15844378934     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.8.1033     Document Type: Article

References (82)

1. Abmayr, S.M., J.L. Workman, and R.G. Roeder. 1988. Thepseudorabies immediate early protein stimulates in vitro transcription by facilitating TFIID: Promoter interaction. Genes & Dev. 2: 542-553.
2. Auble, D.T. and S. Hahn. 1993. An ATP-dependent inhibitor of TBP binding to DNA. Genes & Dev. 7: 844-856.
3. Ayer, D.E., Q.A. Lawerence, and R.N. Eisenman. 1995. Madmax transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast represser sin 3. Cell 80: 767-776.
4. Baniahmad, A., I. Ha, D. Reinberg, S. Tsai, M.J. Tsai, and B.W. O'Malley. 1993. Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone. Proc. Natl. Acad. Sci. 90: 8832-8836.
5. Baxevanis, A.D., G. Arents, E.N. Moundrianakis, and D. Landsman. 1995. A variety of DNA-binding and multimeric proteins contain the histone fold motif. Nucleic Acids Res. 23: 2685-2691.
6. Boulder Committee. 1970. Embryonic vertebrate central nervous system: Revised terminology. Anat. Rec. 166: 257-261.
7. Buratowski, S., S. Hahn, L. Guarente, and P. Sharp. 1989. Five intermediate complexes in transcription initiation by RNA polymerase II Cell 56: 549-561.
8. Chan, Y-L., V. Paz, J. Olevera, and I.G. Wool. 1993. The primary structure of rat ribosomal protein S9. Biochim. Biophys. Acta. 193: 106-112.
9. Chen, J.D. and R.M. Evans. 1995. A transcriptional corepressor that interacts with nuclear hormone receptors. Nature 377: 454-457.
10. Chong, A.A., J. Tapia-Ramirez, S. Kim. J.J. Toledo-Aral, Y. Zheng, M.C. Boutros, Y.M. Altshuller, M.A. Frohman, S.D. Kraner, and G. Mandel. 1995. REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80: 949-957.
11. Choy, B. and M. Green. 1993. Eukaryotic activators function during multiple steps of premitiation complex assembly. Nature 366: 531-536.
12. Cortes, P., O. Flores, and D. Reinberg. 1992. Factors involved in specific transcription by mammalian RNA polymerase II. Purification and analysis of transcription factor IIA and identification of transcription factor IIJ. Mol. Cell. Biol. 12: 413-421.
13. Dynlacht, B.D., T. Hoey, and R. Tjian. 1991. Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. Cell 66: 563-576.
14. Elicone, C., M. Lui, S. Geromanos, H. Erdjument-Bromae, and P. Tempst. 1994. Microbe reversed-phase high-performance liquid chromatographic purification of peptides for combined chemical sequencing/laser-desorption mass spectrometric analysis. J. Chromatogr. 676: 121-137.
15. Elledge, S.J., Z. Zhou, J.B. Allen, and T. Navas. 1993. DNA damage and cell cycle reglation of ribonucleotide reductase. BioEssays 15: 333-339.
16. Erdjument-Bromage, H., M. Lui, D.M. Sabatini, S.H. Snyder, and P. Tempst. 1994. High-sensitivity sequencing of large proteins: Partial structure of the rapamucin-FKB12 target. Prot. Sci. 3: 2435-2446.
17. Ferri, R.T. and P. Levitt. 1993. Cerebral cortical progenitors are fated to produce region-specific neuronal populations. Cereb Cortex 3: 187-198.
18. Flores, O., I. Ha, and D. Reinberg. 1990. Factors involved in specific transcription by mammalian RNA polymerase II. Purification and subunit composition of transcription factor IIF J. Biol. Chem 265: 5629-5634.
19. Flores, O., H. Lu, and D. Reinberg. 1992. Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH. J. Biol. Chem. 267: 2786-2793.
20. Gill, G. and R Tjian. 1992. Eukaryotic coactivators associated with the TATA box binding protein. Curr. Opin. Genet. Dev 2: 236-242
21. Ha, I., W.S. Lane, and D. Reinberg. 1991. Cloning of a human gene encoding the general transcription initiation factor IIB. Nature 352: 689-695.
22. Harlow, E. and D Lane. 1988. Antibodies: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
23. Herschbach, B.M. and A.D. Johnson. 1993 Transcriptional repression in eukaryotes. Annu. Rev. Cell. Biol. 9: 479-509.
24. Hicks, S.P. and C.J. D'Amato. 1968. Cell migrations to the isocortex in the rat. Anat. Rec. 160: 619-634.
25. Hoffmann, A. and R.G. Roeder. 1991. Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies. Nucleic Acids Res 19: 6337-6338.
26. Hoffman, A., E. Sinn, T. Yamamoto, J. Wang, A. Roy, M. Horikoshi, and R.G. Roeder. 1990. Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID). Nature 346: 387-390.
27. Horlein, A.J., A.M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamel, M. Soderstrom, C. Glass, and M.G. Rosenfeld. 1995. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377: 397-404.
28. Inostroza, J.A., F.H. Mermelstein, I. Ha, W.S. Lane, and D. Reinberg. 1992. Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. Cell 70: 477-489.
29. Johnson, A.D. 1995. The price of repression. Cell 81: 655-658.
30. Johnson, F.B. and M.A. Krasnow. 1992. Differential regulation of transcription preinitiation complex assembly by activator and repressor homeo domain proteins. Genes & Dev. 6: 2177-2189.
31. Kao, C.C., P.M. Lieberman, M.C. Schmidt, Q. Zhou, R. Pei, and A.J. Berk. 1990. Cloning of a transcriptionally active human TATA binding factor. Science 248: 1646-1650.
32. Keleher, C.A., J. Redd, M. Schultz, M. Carlson, and A.D. Johnson. 1992. Ssn6-Tup1 is a general repressor of transcription yeast. Cell 68: 709-719.
33. Kim, T.K., Y. Zhao, H. Ge, R. Bernstein, and R.G. Roeder. 1995. TATA-binding protein residues implicated in a functional interplay between negative cofactor NC2 (Dr1) and general factors TFIIA and TFIIB. J. Biol. Chem. 270: 10976-10981.
34. Koleske, A.J. and R.A. Young. 1995. An RNA polymerase II holoenzyme responsive to activators. Nature 368: 466-469.
35. Kraus, V.B., J.A. Inostroza, K. Yeung, D. Reinberg, and J R. Nevins. 1994. Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A. Proc. Natl. Acad. Sci. 91: 6279-6282.
36. Kurokawa, R., M. Soderstrom, A. Horlein, S. Halachml, M. Brown, M.G. Rosenfeld, and C.K. Glass. 1995. Polarity-specific activities of retinoic acid receptors determined by a corepressor. Nature 377: 451-454.
37. Lee, G., J. Wu, P. Luu, P. Gazal, and O. Flores. 1996. Inhibition of the association of RNA polymerase II with the preinitiation complex by a viral transcriptional repressor. Proc. Natl. Acad. Sci. 93: 2570-2575
38. Lee, S. and S. Hahn. 1995. Model for binding of transcription factor TFIIB to the TBP-DNA complex. Nature 376: 609-612.
39. Levitt, P. 1944. Experimental approaches that reveal principles of cerebra cortical development. In The cognitive neurosciences (ed. M.S. Gazzaniga), pp. 147-163. MIT Press, New York, NY.
40. Lehming, N., D. Thanos, J.M. Brickmean, J. Ma, T. Maniatis, and M. Ptashne. 1994. An HMG-like protein that can switch a transcriptional activator to a repressor. Cell 371: 175-179.
41. Lieberman, P.M. and A.J. Berk. 1994. A mechanism for TAFs in transcriptional activation: Activation domain enhancement of TFIID-TFIIA-promoter DNA complex formation. Genes & Dev. 8: 995-1006.
42. Liu, B., W. Hermisten, and M.F. Stinski. 1991. A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2. J. Virol. 65: 897-903.
43. Lu, H., O. Flores, R. Weinmann, and D. Reinberg. 1991. The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex. Proc. Natl Acad. Sci. 88: 10004-10008.
44. Ma, D., H. Watanabe, F. Mermelstein, A. Admon, K. Oguri, X. Sun, T. Wada, T. Imai, D. Shiroya, D. Reinberg, and H. Honda. 1993. Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. Genes & Dev. 7: 2246-2257.
45. Maheswaran, S., S. Park, A. Bernard, J.F. Morris, F.J. Rauscher, D.E. Hill, and D.A. Haber. 1993. Physical and functional interaction between WT1 and p53 proteins. Proc Natl. Acad. Sci. 90: 5100-5104.
46. Maldonado, E. and D. Reinberg. 1995. News on initiation and elongation of transcription by RNA polymerase II. Curr. Opin. Cell. Biol. 7: 352-361.
47. Maldonado, E., I. Ha, P. Cortes, L. Weis, and D. Reinberg. 1990. Factors involved in specific transcription by mammalian RNA polymerase II: Role of transcription factors ILA, IID, and IIB during formation of a transcription-competent complex. Mol. Cell. Biol. 10: 6335-6347.
48. Maxon, M.E., J.A. Goodrich, and R. Tjian. 1994. Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: A model for promoter clearance. Genes & Dev. 8: 515-524.
49. McNabb, D.S., Y. Xing, and L. Guarente. 1995. Cloning of yeast HAP5: A novel subunit of a heterotrimeric complex required for CCAAT binding. Genes and Dev. 9: 47-58.
50. Meisterernst, M. and R.G. Roeder. 1991. Family of proteins that interact with TFIID and regulate promoter activity. Cell 67: 557-567.
51. Meisterernst, M., A.L. Roy, H.M. Lieu, and R.G. Roeder. 1991. Activation of class II gene transcription by regulatory factors is potentiated by a novel activity. Cell 66: 981-993.
52. Mukai, Y., S. Harashima, Y. Oshima. 1991. AAR1/TUP1 protein, with a structural similar to that of the β subunit of G proteins, is required for al-α2 and α2 repression in cell type control of Saccharomyces cerevisiae. Mol. Cell. Biol. 11: 3773-3779.
53. Nakajima, N., M. Horikoshi, and R.G. Roeder. 1988. Factors involved in specific transcription by mammalian RNA polymerase II: Purification, genetic specificity, and TATA box-promoter interactions of TFIID. Mol. Cell. Biol. 8: 4028-4040.
54. Nikolov, D.E., H. Chen, E.D. Halay, A.A. Usheva, K. Hisatake, D.K. Lee, R.G. Roeder, and S.K. Burley. 1995. Crystal structure of a TFIIB-TBP-TATA element ternary complex. Nature 377: 119-128.
55. Ossipow, V., J.-P. Tassan, E.A. Nigg, and U. Schibler. 1995. A mammalian RNA polymerase II holoenzyme containing all components requried for promoter-specific transcription initiation. Cell 83: 137-146.
56. Ozer, J., P.A. Moore, A.H. Bolden, A. Lee, C.A. Rosen, and P.M. Liberman. 1994. Molecular cloning of the small (γ) subunit of human TFIIA reveals functions critical for activated transcription. Genes & Dev. 8: 2324-2335.
57. Paroush, Z., R.L. Finley, T. Kidd, S.M. Wainwright, P.W. Ingham, R. Brent, and D. Ish-Horowicz. 1994. Groucho is required for Drosophila neurogenesis segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 79: 805-815.
58. Peterson, M.G., N. Tanese, B.F. Pugh, and R. Tjian. 1990. Functional domains and upstream activation properties of cloned human TATA binding protein. Science 248: 1625-1630.
59. Pugh, B.F. and R. Tjian. 1991. Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes & Dev. 5: 1935-1945.
60. Roberts, S.G. and M.R. Green. 1995. Transcription. Dichotomous regulators. Nature 375: 105-106.
61. Sauer, F. and H. Jäckle. 1993. Dimerization and the control of transcription by Krüppel. Nature 364: 454-457.
62. Sauer, F., J.D. Fondell, Y. Ohkuma, R.G. Roeder, and H. Jäckle. 1995. Control of transcription by Krüppel through interactions with TFIIB and TFIIE beta. Nature 375: 162-164.
63. Schreiber-Agus, N., L. Chin, K. Chen, R. Torres, G. Rao, P. Guida, A.I. Skoultchi, and R.A. DePinho. 1995. An aminoterminal domain of Mxil mediates anti-myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80: 777-786.
64. Schultz, J. and M. Carlson. 1987. Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae. Mol. Cell Biol. 7: 3637-3645.
65. Seto, E., A. Usheva, G.P. Zambetti, J. Momand, N. Horikoshi, R. Weinmann, A.J. Levine, and T. Shenk. 1992. Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc Natl. Acad. Sci. 89: 12028-12032.
66. Sun, X., D. Ma, M Sheldon, K. Yeung, and D. Reinberg. 1994. Reconstitution of human TFIIA activity from recombinant polypeptides: A role in TFIID-mediated transcription. Genes & Dev. 8: 2336-2348.
67. Tang, H., X. Sun, D. Reinberg, and R.H. Ebright. 1996. Protein-protein interactions in eukaryotic transcription initiation: Structure of the pre-initiation complex. Proc. Natl. Acad. Sci. 93: 1119-1124.
68. Tanese, N., B.F. Pugh, and R. Tjian. 1991. Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex. Genes & Dev. 5: 2212-2224.
69. Tatusov, R.L., S.F. Altschul, and E.V. Koonin. 1994. Detection of conserved segments in proteins: Iterative scanning of sequence databases with alignment blocks. Proc. Natl. Acad. Sci. 6: 12091-12095.
70. Tempst, P., A.J. Link, L.R. Riviere, M. Fleming, and C. Elicone. 1990. Internal sequence analysis of proteins separated on polyacrylamide gels at the submicrogram level: Improved methods, applications and gene cloning strategies. Electrophoresis 11: 537-533.
71. Tempst, P., S. Geromanos, C. Elicone, and H. Erdjument-Bromage. 1994. Improvements in microsequencer performance for low picomole sequence analysis. Methods: Companion Methods Enzymol. 6: 248-261.
72. Topol, J. and C.S. Parker. 1984. A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA binding activity. Cell 36: 357-369.
73. Trumbly, R.J 1992. Glucose repression in the yeast Saccharomyces cerevisiae. Mol Microbiol. 6: 15-21.
74. Tzamarias, D. and K. Struhl. 1994. Functional dissection of the yeast Cyc8-Tup1 transcriptional corepressor complex. Nature 369: 758-761.
75. _. 1995. Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes & Dev. 9: 821-831.
76. White, R.J., B.C.-E. Khoo, J.A. Inostroza, D. Reinberg, and S.P. Jackson. 1994. Differential regulation of RNA polymerase I, II, and III by the TBP-binding repressor, Dr1. Science 266: 448-451.
77. Yeung, K.C., J.A. Inostroza, F.H. Mermelstein, C. Kannabiran, and D. Reinberg. 1994. Structure-function analysis of the TBP-binding protein Dr1 reveals a mechanism for repression of class II gene transcription. Genes & Dev. 8: 2097-2109.
78. Yokomori, K., M.P. Zeidler, J.L. Chen, C.P. Verrijzer, M. Mlodzik, and R. Tjian. 1994. Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. Genes & Dev. 8: 2313-2323.
79. Zawel, L. and D. Reinberg. 1993. Initiation of transcription by RNA polymerase II: A multi-step process.Prog. Nucleic Acid Res. Mol. Biol. 44: 67-108.
80. _. 1995. Common themes in assembly and function of eukaryotic transcription complexes. Annu. Rev. Biochem. 64: 533-561.
81. Zhou, Q., P.M. Lieberman, T.G. Boeyer, and A.J. Berk. 1992. Holo-TFIID supports transcriptional stimulation by diverse activators and from TATA-less promoters. Genes & Dev. 6: 1964-1974.
82. Zitomer, R. S. and C.V. Lowry. 1992. Regulation of gene expression by oxygen in Saccharomyces cerevisiae. Microbiol. Rev. 56: 1-11.