Internal DNA deletion within the BCL-6 gene on untranslocated chromosome in non-Hodgkin's lymphoma with 3q27 abnormality

Leukemia

Volumn 10, Issue 4, 1996, Pages 658-661

  Nakamura, Y ^a   Miki, T ^b   Miura, I ^c   Hashimoto, K ^c   Miura, A ^c   Akimoto, K ^a   Hirosawa, S ^b   Saito, K ^a   Enokihara, H ^a   Furusawa, S ^a   Shishido, H ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c AKITA UNIVERSITY   (Japan)

Author keywords

B cell lymphoma; BCL 6 gene; DNA deletion

Indexed keywords

DNA; PROTEIN BCL 2;

ADULT; ARTICLE; CASE REPORT; CHROMOSOME 3Q; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA RECOMBINATION; EXON; GENE DELETION; GENE REARRANGEMENT; GENE STRUCTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN GENE; INTRON; MALE; NONHODGKIN LYMPHOMA; ONCOGENE; PRIORITY JOURNAL; SOUTHERN BLOTTING;

EID: 15844374513     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Offit K, Jhanwar S, Ebrahim SAD, Filippa D, Clarkson BD, Chaganti RSK t(3;22)(q27;q11): a novel translocation associated with diffuse non-Hodgkin's lymphoma. Blood 1989; 74: 1876-1879
2. Bastard C, Tilly H, Lenormand B, Bigorgne C, Boulet D, Kunlin A, Monconduit M, Piguet H. Translocations involving band 3q27 and Ig gene regions in non-Hodgkin's lymphoma. Blood 1992:79: 2527-2531.
3. Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 1993; 262: 747-750.
4. Kerckaert J-P, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nat Genet 1993; 5: 66-70.
5. Miki T, Kawamata N, Hirosawa S, Aoki N. Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein. Blood 1994; 83: 26-32.
6. Baron BW, Nucifola G, McCabe N, Espinosa R III, Le Beau MM, McKeithan TW. Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22) (q27;q11) in B-cell lymphomas. Proc Natl Acad Sci USA 1993; 90: 5262-5266.
7. Deweindt C, Kerckaert J-P, Tilly H, Quief S, Nguyen VC, Bastard C. Cloning of a breakpoint cluster region at band 3q27 involved in human non-Hodgkin's lymphoma. Genes Chromosom Cancer 1993; 8: 149-154.
8. Ye BH, Rao PH, Chaganti RSK, Dalla-Favera R. Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B cell lymphoma. Cancer Res 1993; 53: 2732-2735.
9. Miki T, Kawamata N, Arai A, Ohashi K, Nakamura Y, Kato A, Hirosawa S, Aoki N. Molecular cloning of the breakpoint for 3q27 translocation in B cell lymphomas and leukemias. Blood 1994; 83: 217-222.
10. Onizuka T, Moriyama M, Yamochi T, Kuroda T, Kazama A, Kanazawa N, Sato K, Kato T, Ota H, Mori S. BCL-6 gene product, a 92-to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 1995; 86: 28-37.
11. Cattoretti G, Chang C-C, Cechova K, Zhang J, Ye BH, Falini B, Louie DC, Offit K, Chaganti RSK, Dalta-Favera R. BCL-6 protein is expressed in germinal-center B cells. Blood 1995; 86: 45-53.
12. Lo Coco F, Ye BH, Lista F, Corradini P, Offit K, Knowles DM, Chaganti RSK, Dalla-Favera R. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 1994; 83: 1757-1759.
13. Bastard C, Deweindt C, Kerckaert J-P, Lenormand B, Rossi A, Pezzella F, Fruchart C, Duval C, Monconduit M, Tilly H. LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 1994; 83: 2423-2427.
14. Offit K, Lo Coco F, Louie DG, Parsa NZ, Leung D, Portlock C, Ye BH, Lista F, Filippa DA, Rosenbaum A, Ladanyl M, Jhanwar S, Dalla-Favera R, Chaganti R. Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. New Engl J Med 1994; 331: 74-80.
15. Ohno H, Kerckaert J-P, Bastard C, Fukuhara S. Heterogeneity in B-cell neoplasms associated with rearrangement of the LAZ3 gene on chromosome band 3q27. Jpn J Cancer Res 1994; 85: 592-600.
16. Otsuki T, Yano T, Clark HM, Bastard C, Kerckaert JP, Jaffe ES, Raffeld M. Analysis of LAZ3 (BCL-6) status in B cell non-Hodgkin's lymphomas: results of rearrangement and gene expression studies and a mutational analysis of coding region sequences. Blood 1995; 10: 2877-2884.
17. Nakamura Y, Miki T, Kawamata N, Hirosawa S, Saito K, Enokihara H, Furusawa S, Shishido H. Biallelic DNA rearrangements and deletions within the BCL-6 gene in B cell non-Hodgkin's lymphoma. Br J Haematol 1995; 90: 404-408.
18. The Non-Hodgkin's Lymphoma Pathologic Classification Project. National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. Cancer 1982; 49: 2112-2135.
19. Ghanem N, Dariavach P, Bensmana M, Chibani J, Lefranc G, Lefranc MP. Polymorphism of immunoglobulin lamda constant genes in populations from France, Lebanon and Tunisia. Exp Clin Immunogenet 1988; 5: 186-195.
20. Kawamata N, Miki T, Fukuda T, Hirosawa S, Aoki N. The organization of the BCL6 gene. Leukemia 1994; 8: 1327-1330.
21. Tonegawa S. Somatic generation of antibody diversity. Nature 1983; 302: 575-581.
22. Brown L, Cheng J-T, Chen Q, Siciliano MJ, Crist W, Buchanan G, Baer R. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J 1990; 9: 3343-3351.