메뉴 건너뛰기




Volumn 12, Issue 2, 1996, Pages 83-102

Neurotoxic effects on the dopaminergic system induced by TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline), a potential mammalian alkaloid: In vivo and in vitro studies

Author keywords

Dopaminergic neurotoxicity; Highly halogenated carbolines; Histological findings in vitro and in vivo; In vivo pulse voltammetry; Locomotor activity; Mitochondrial respiration; Parkinsonism; TaClo (1 trichloromethyl 1,2,3,4 tetrahydro carboline)

Indexed keywords

1 TRICHLOROMETHYL 1,2,3,4 TETRAHYDRO BETA CARBOLINE; BETA CARBOLINE DERIVATIVE; CHLORAL HYDRATE; DOPAMINE; SOLVENT; TRICHLOROETHYLENE; TRYPTAMINE; UNCLASSIFIED DRUG;

EID: 15844367456     PISSN: 01688561     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (17)

References (54)
  • 1
    • 0025688141 scopus 로고
    • Mitochondrial respiratory inhibition by N-methylated β-carboline derivatives structurally resembling N-methyl-4-phenylpyridine
    • Albores, R., Neafsey, E. J., Drucker, G., Fields, J. Z. and Collins, M. A. (1990). Mitochondrial respiratory inhibition by N-methylated β-carboline derivatives structurally resembling N-methyl-4-phenylpyridine. Proc. Natl. Acad. Sci. USA 87, 9368-9372.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 9368-9372
    • Albores, R.1    Neafsey, E.J.2    Drucker, G.3    Fields, J.Z.4    Collins, M.A.5
  • 2
    • 0020040906 scopus 로고
    • Long-term development of mesencephalic dopaminergic neurons of mouse embryos in dissociated primary cultures: Morphological and histochemical characteristics
    • Berger, B., di Porzio, U., Daguet, M. C., Gay, M., Vigny, A., Glowinski, J. and Prochiantz, A. (1982). Long-term development of mesencephalic dopaminergic neurons of mouse embryos in dissociated primary cultures: morphological and histochemical characteristics. Neurosci. Lett. 7, 193-205.
    • (1982) Neurosci. Lett. , vol.7 , pp. 193-205
    • Berger, B.1    Di Porzio, U.2    Daguet, M.C.3    Gay, M.4    Vigny, A.5    Glowinski, J.6    Prochiantz, A.7
  • 3
    • 0000854861 scopus 로고
    • Growth of a rat neuroblastoma cell line in serum-free supplemented medium
    • Bottenstein, J. E. and Sato, G. H. (1979). Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl. Acad. Sci. U.S.A. 76, 514-517.
    • (1979) Proc. Natl. Acad. Sci. U.S.A. , vol.76 , pp. 514-517
    • Bottenstein, J.E.1    Sato, G.H.2
  • 4
    • 0025490465 scopus 로고
    • 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline - A potential chloral-derived indole alkaloid in man
    • Bringmann, G. and Hille, A. (1990). 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline - a potential chloral-derived indole alkaloid in man. Arch. Pharm. 323, 567-569.
    • (1990) Arch. Pharm. , vol.323 , pp. 567-569
    • Bringmann, G.1    Hille, A.2
  • 5
    • 0026333105 scopus 로고
    • Endogenous alkaloids in man - Synthesis, analytics, in vivo identification, and medicinal importance
    • Bringmann, G., Feineis, D., Friedrich, H. and Hille, A. (1991). Endogenous alkaloids in man - synthesis, analytics, in vivo identification, and medicinal importance. Planta Med. 57 [Suppl. 1], 73-84.
    • (1991) Planta Med. , vol.57 , Issue.1 SUPPL. , pp. 73-84
    • Bringmann, G.1    Feineis, D.2    Friedrich, H.3    Hille, A.4
  • 6
    • 0027008311 scopus 로고
    • Trichloroharmanes as potential endogenously formed inducers of Morbus Parkinson: Synthesis, analytics, and first in vivo investigations
    • Bringmann, G., Friedrich, H. and Feineis, D. (1992). Trichloroharmanes as potential endogenously formed inducers of Morbus Parkinson: synthesis, analytics, and first in vivo investigations. J. Neural Transm. [Suppl.] 38, 15-26.
    • (1992) J. Neural Transm. [Suppl.] , vol.38 , pp. 15-26
    • Bringmann, G.1    Friedrich, H.2    Feineis, D.3
  • 8
    • 0029414758 scopus 로고
    • TaClo as a neurotoxic lead: Improved synthesis, stereochemical analysis, and inhibition of the mitochondrial respiratory chain
    • Bringmann, G , God, R., Feineis, D., Janetzky, B., and Reichmann, H. (1995b). TaClo as a neurotoxic lead: improved synthesis, stereochemical analysis, and inhibition of the mitochondrial respiratory chain. J. Neural Transm. [Suppl.] 46, 241-250.
    • (1995) J. Neural Transm. [Suppl.] , vol.46 , pp. 241-250
    • Bringmann, G.1    God, R.2    Feineis, D.3    Janetzky, B.4    Reichmann, H.5
  • 9
    • 0024390938 scopus 로고
    • Metabolism, toxicity, and carcinogenicity of trichloroethylene
    • Bruckner, J. V., Davis, B. D. and Blancato, J. N. (1989). Metabolism, toxicity, and carcinogenicity of trichloroethylene. Crit. Rev. Toxicol. 20, 31-50.
    • (1989) Crit. Rev. Toxicol. , vol.20 , pp. 31-50
    • Bruckner, J.V.1    Davis, B.D.2    Blancato, J.N.3
  • 10
    • 0001496694 scopus 로고
    • A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Burns, R. S., Chiueh, C. C., Markey, S. P., Ebert, M. H., Jacobowitz, D. M. and Kopin, I. J. (1983). A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. U.S.A. 80, 4546-4550.
    • (1983) Proc. Natl. Acad. Sci. U.S.A. , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 11
    • 0021089452 scopus 로고
    • On the aetiology of Parkinson's disease
    • Calne, D. B. and Langston, J. W. (1983). On the aetiology of Parkinson's disease. Lancet ii, 1457-1459.
    • (1983) Lancet , vol.2 , pp. 1457-1459
    • Calne, D.B.1    Langston, J.W.2
  • 12
    • 0019481135 scopus 로고
    • Differential pulse voltammetry in brain tissue. 2. Detections of 5-hydroxyindolacetic acid in the rat striatum
    • Cespuglio, R., Faradji, H., Buda, M., Gonon, F., Pujol, J. F. and Jouvet, M. (1981). Differential pulse voltammetry in brain tissue. 2. Detections of 5-hydroxyindolacetic acid in the rat striatum. Brain Res. 223, 299-311.
    • (1981) Brain Res. , vol.223 , pp. 299-311
    • Cespuglio, R.1    Faradji, H.2    Buda, M.3    Gonon, F.4    Pujol, J.F.5    Jouvet, M.6
  • 13
    • 0028176878 scopus 로고
    • + in PC12 cells: Insights into potential neurotoxicants in Parkinson's disease
    • + in PC12 cells: insights into potential neurotoxicants in Parkinson's disease. J. Neurochem. 62, 1503-1510.
    • (1994) J. Neurochem. , vol.62 , pp. 1503-1510
    • Cobuzzi Jr., R.J.1    Neafsey, E.J.2    Collins, M.A.3
  • 14
    • 0021992979 scopus 로고
    • β-Carboline analogues of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP): Endogenous factors underlying idiopathic parkinsonism?
    • Collins, M. A. and Neafsey, E. J. (1985). β-Carboline analogues of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP): endogenous factors underlying idiopathic parkinsonism? Neurosci. Lett. 55, 179-184.
    • (1985) Neurosci. Lett. , vol.55 , pp. 179-184
    • Collins, M.A.1    Neafsey, E.J.2
  • 15
    • 0006034805 scopus 로고
    • Halogenated Cyclic Hydrocarbons
    • G. D. Clayton and F. E. Clayton (Eds). Wiley and Sons, New York, Chichester, Brisbane, Toronto, Singapore, 3rd edn.
    • Deichmann, W. B. (1981). Halogenated Cyclic Hydrocarbons. In: Patty's Industrial Hygiene and Toxicology, G. D. Clayton and F. E. Clayton (Eds). Wiley and Sons, New York, Chichester, Brisbane, Toronto, Singapore, 3rd edn., Vol. 2B, pp. 3687-3701.
    • (1981) Patty's Industrial Hygiene and Toxicology , vol.2 B , pp. 3687-3701
    • Deichmann, W.B.1
  • 17
    • 0025101783 scopus 로고
    • Dopamine uptake inhibitory capacities of β-carboline and 3,4-dihydro-β-carboline anaiogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation products
    • Drucker, G., Raikoff, K., Neafsey, E. J. and Collins, M. A. (1990). Dopamine uptake inhibitory capacities of β-carboline and 3,4-dihydro-β-carboline anaiogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation products. Brain Res. 509, 125-133.
    • (1990) Brain Res. , vol.509 , pp. 125-133
    • Drucker, G.1    Raikoff, K.2    Neafsey, E.J.3    Collins, M.A.4
  • 19
    • 0019306957 scopus 로고
    • In vivo electrochemical detection of catechols in the neostriatum of anaesthetized rats: Dopamine or DOPAC?
    • Gonon, F., Buda, M., Cespuglio, R., Jouvet, M. and Pujol, J. F. (1980). In vivo electrochemical detection of catechols in the neostriatum of anaesthetized rats: dopamine or DOPAC? Nature 286, 902-904.
    • (1980) Nature , vol.286 , pp. 902-904
    • Gonon, F.1    Buda, M.2    Cespuglio, R.3    Jouvet, M.4    Pujol, J.F.5
  • 20
    • 0029414761 scopus 로고
    • Biochemical lesions of the nigrostriatal system induced by TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) and derivatives
    • Grote, C., Clement, H.-W., Wesemann, W., Bringmann, G., Feineis, D., Riederer, P. and Sontag, K.-H. (1995). Biochemical lesions of the nigrostriatal system induced by TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) and derivatives. J. Neural Transm. [Suppl.] 46, 271-277.
    • (1995) J. Neural Transm. [Suppl.] , vol.46 , pp. 271-277
    • Grote, C.1    Clement, H.-W.2    Wesemann, W.3    Bringmann, G.4    Feineis, D.5    Riederer, P.6    Sontag, K.-H.7
  • 21
    • 0029414754 scopus 로고
    • 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline, a new inhibitor of complex I
    • Janetzky, B., God, R., Bringmann, G. and Reichmann, H. (1995). 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline, a new inhibitor of complex I. J. Neural Transm. [Suppl.] 46, 260-270.
    • (1995) J. Neural Transm. [Suppl.] , vol.46 , pp. 260-270
    • Janetzky, B.1    God, R.2    Bringmann, G.3    Reichmann, H.4
  • 22
    • 0002195916 scopus 로고
    • + induced neurotoxicity in rodents and the common marmosets as experimental models for investigating Parkinson's disease
    • S.P. Markey, N. Castagnoli Jr., A.J. Trevor and I.J. Kopin (Eds.). Academic Press Inc, Orlando, San Diego, New York
    • + induced neurotoxicity in rodents and the common marmosets as experimental models for investigating Parkinson's disease. In: MPTP: A neurotoxin producing a parkinsonian syndrome, S.P. Markey, N. Castagnoli Jr., A.J. Trevor and I.J. Kopin (Eds.). Academic Press Inc, Orlando, San Diego, New York, pp. 45-68.
    • (1986) MPTP: A Neurotoxin Producing a Parkinsonian Syndrome , pp. 45-68
    • Jenner, P.1    Marsden, C.D.2    Costall, B.3    Naylor, R.J.4
  • 23
    • 77957014831 scopus 로고
    • 1 particle, and reconstitution of succinate-cytochrome c reductase
    • 1 particle, and reconstitution of succinate-cytochrome c reductase. Methods Enzymol. 10, 216-225.
    • (1967) Methods Enzymol. , vol.10 , pp. 216-225
    • King, T.E.1
  • 27
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston, J W., Ballard P. A., Tetrud, J. W. and Irwin, I. (1983). Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.A.2    Tetrud, J.W.3    Irwin, I.4
  • 31
    • 0018508742 scopus 로고
    • Normal pulse polarography with carbon fibre electrodes for in vitro and in vivo determination of catecholamines
    • Ponchon, J. L., Cespuglio, R., Gonon, F., Jouvet, M. and Pujol, J. F. (1979). Normal pulse polarography with carbon fibre electrodes for in vitro and in vivo determination of catecholamines. Anal. Chem. 51, 1483-1486.
    • (1979) Anal. Chem. , vol.51 , pp. 1483-1486
    • Ponchon, J.L.1    Cespuglio, R.2    Gonon, F.3    Jouvet, M.4    Pujol, J.F.5
  • 32
    • 0001889165 scopus 로고
    • Sub-fractionation of mitochondria and isolation of the proteins of oxidative phosphorylation
    • V. M. Darley-Usmar, D. Rickwood and M. T. Wilson (Eds). IRL Press, Oxford, Washington DC
    • Ragan, C. I., Wilson, M. T., Darley-Usmar, V. M. and Lowe, P. N. (1987). Sub-fractionation of mitochondria and isolation of the proteins of oxidative phosphorylation. In: Mitochondria, a practical approach, V. M. Darley-Usmar, D. Rickwood and M. T. Wilson (Eds). IRL Press, Oxford, Washington DC, pp. 79-112.
    • (1987) Mitochondria, a Practical Approach , pp. 79-112
    • Ragan, C.I.1    Wilson, M.T.2    Darley-Usmar, V.M.3    Lowe, P.N.4
  • 33
    • 0002399592 scopus 로고
    • Hypnotics and sedatives; ethanol
    • A. Goodman Gilman, T. W. Rall, A. S. Nies and P. Taylor (Eds). Pergamon Press, New York, Oxford, Beijing, Frankfurt, São Paulo, Sydney, Tokyo, Toronto, 8th edn.
    • Rall, T. W. (1990). Hypnotics and sedatives; ethanol. In: Goodman and Gilman's The Pharmacological Basis of Therapeutics, A. Goodman Gilman, T. W. Rall, A. S. Nies and P. Taylor (Eds). Pergamon Press, New York, Oxford, Beijing, Frankfurt, São Paulo, Sydney, Tokyo, Toronto, 8th edn., pp. 357, 464-365.
    • (1990) Goodman and Gilman's the Pharmacological Basis of Therapeutics , pp. 357
    • Rall, T.W.1
  • 34
    • 85012614648 scopus 로고
    • Isolation of astrocytes and Schwann cells for cultures
    • Academic Press Inc., Harcourt Brace Jovanovich, Publishers, San Diego, New York, Boston, London, Syndey, Tokyo, Toronto
    • Ramon, L. and Bosch, E. P. (1990). Isolation of astrocytes and Schwann cells for cultures. In: Methods in Neurosciences, Vol. 2, cell cultures. Academic Press Inc., Harcourt Brace Jovanovich, Publishers, San Diego, New York, Boston, London, Syndey, Tokyo, Toronto, pp. 47-56.
    • (1990) Methods in Neurosciences, Vol. 2, Cell Cultures , vol.2 , pp. 47-56
    • Ramon, L.1    Bosch, E.P.2
  • 35
    • 0022447784 scopus 로고
    • Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP
    • Ramsay R. R., Dadgar, J., Trevor, A. and Singer, T. P. (1986). Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP. Life Sci. 39, 581-588.
    • (1986) Life Sci. , vol.39 , pp. 581-588
    • Ramsay, R.R.1    Dadgar, J.2    Trevor, A.3    Singer, T.P.4
  • 36
    • 0029414752 scopus 로고
    • Studies of the potentially endogenous toxin TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) in neuronal and glial cell cultures
    • Rausch, W.-D., Abdel-mohsen, M., Koutsilieri, E., Chan, W. W. and Bringmann, G. (1995). Studies of the potentially endogenous toxin TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) in neuronal and glial cell cultures. J. Neural Transm. [Suppl.] 46, 251-259.
    • (1995) J. Neural Transm. [Suppl.] , vol.46 , pp. 251-259
    • Rausch, W.-D.1    Abdel-mohsen, M.2    Koutsilieri, E.3    Chan, W.W.4    Bringmann, G.5
  • 37
    • 0021837948 scopus 로고
    • Biochemical and ultrastructural changes of skeletal muscle mitochondria after chronic electrical stimulation in rabbits
    • Reichmann, H., Hoppeler, H., Mathieu-Costello, O., von Berger, F. and Pette, D. (1985). Biochemical and ultrastructural changes of skeletal muscle mitochondria after chronic electrical stimulation in rabbits. Plûgers Arch. 404, 1-9.
    • (1985) Plûgers Arch. , vol.404 , pp. 1-9
    • Reichmann, H.1    Hoppeler, H.2    Mathieu-Costello, O.3    Von Berger, F.4    Pette, D.5
  • 38
    • 0001883657 scopus 로고
    • Isolation and characteristics of intact mitochondria
    • V. M. Darley-Usmar, D. Rickwood and M. T. Wilson (Eds). IRL Press, Oxford, Washington DC
    • Rickwood, D., Wilson, M. T. and Darley-Usmar, V. M. (1987). Isolation and characteristics of intact mitochondria. In: Mitochondria, a practical approach, V. M. Darley-Usmar, D. Rickwood and M. T. Wilson (Eds). IRL Press, Oxford, Washington DC, pp. 1-16.
    • (1987) Mitochondria, a Practical Approach , pp. 1-16
    • Rickwood, D.1    Wilson, M.T.2    Darley-Usmar, V.M.3
  • 39
    • 0001525440 scopus 로고
    • An enzymatic approach to the study of the Krebs tricarboxylic acid cycle
    • V. M. Darley-Usmar, D. Rickwood and M. T. Wilson (Eds). IRL Press, Oxford, Washington DC
    • Robinson, J. B., Brent, L. G., Sumegi, B. and Srere, P. A. (1987). An enzymatic approach to the study of the Krebs tricarboxylic acid cycle. In: Mitochondria, a practical approach, V. M. Darley-Usmar, D. Rickwood and M. T. Wilson (Eds). IRL Press, Oxford, Washington DC, pp. 153-170.
    • (1987) Mitochondria, a Practical Approach , pp. 153-170
    • Robinson, J.B.1    Brent, L.G.2    Sumegi, B.3    Srere, P.A.4
  • 40
    • 0019639322 scopus 로고
    • Nerve outgrowth, synaptogenesis and bioelectric activity in fetal rat cerebral cortex tissue cultured in serum-free, chemically defined medium
    • Romijin, H. J., Habets, A. M. C., Mud, M. T. and Wolters, P. S. (1982). Nerve outgrowth, synaptogenesis and bioelectric activity in fetal rat cerebral cortex tissue cultured in serum-free, chemically defined medium. Dev. Brain. Res. 2, 583-589.
    • (1982) Dev. Brain. Res. , vol.2 , pp. 583-589
    • Romijin, H.J.1    Habets, A.M.C.2    Mud, M.T.3    Wolters, P.S.4
  • 41
    • 0014216603 scopus 로고
    • Mechanism of aconitase action. I. The hydrogen transfer reaction
    • Rose, I. A. and O'Connell, E. L. (1967). Mechanism of aconitase action. I. The hydrogen transfer reaction. J. Biol. Chem. 242, 1870-1879.
    • (1967) J. Biol. Chem. , vol.242 , pp. 1870-1879
    • Rose, I.A.1    O'Connell, E.L.2
  • 42
    • 0026696122 scopus 로고
    • Cryopreservation, survival and function of intrastriatal fetal mesencephalic grafts in a rat model of Parkinson's disease
    • Sauer, H., Frodl, E. M., Kupsch, A., ten Bruggencate, G. and Oertel, W. H. (1992). Cryopreservation, survival and function of intrastriatal fetal mesencephalic grafts in a rat model of Parkinson's disease. Exp. Brain Res. 90, 54-62.
    • (1992) Exp. Brain Res. , vol.90 , pp. 54-62
    • Sauer, H.1    Frodl, E.M.2    Kupsch, A.3    Ten Bruggencate, G.4    Oertel, W.H.5
  • 43
    • 0025747972 scopus 로고
    • Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances
    • Sayre, L. M., Wang, F., Arora, P. K., Riachi, N. J., Hank, S. I. and Hoppel, C. L. (1991). Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances. J. Neurochem. 57, 2106-2115.
    • (1991) J. Neurochem. , vol.57 , pp. 2106-2115
    • Sayre, L.M.1    Wang, F.2    Arora, P.K.3    Riachi, N.J.4    Hank, S.I.5    Hoppel, C.L.6
  • 44
    • 0014059118 scopus 로고
    • An electron transport system associated with the outer membrane of the mitochondria
    • Scottocasa, G. L., Kuylenstierna, B., Ernster, L. and Bergstrand, A. (1967). An electron transport system associated with the outer membrane of the mitochondria. J. Cell. Biol. 32, 415-438.
    • (1967) J. Cell. Biol. , vol.32 , pp. 415-438
    • Scottocasa, G.L.1    Kuylenstierna, B.2    Ernster, L.3    Bergstrand, A.4
  • 45
    • 0000779364 scopus 로고
    • Biochemistry of the neurotoxic action of MPTP: Or how a faulty batch of 'designer drug' led to parkinsoism in drug abusers
    • Singer, T. P., Trevor, A. J. and Castagnoli Jr., N. (1987). Biochemistry of the neurotoxic action of MPTP: or how a faulty batch of 'designer drug' led to parkinsoism in drug abusers. Trends Biochem. Sci. 12, 266-270.
    • (1987) Trends Biochem. Sci. , vol.12 , pp. 266-270
    • Singer, T.P.1    Trevor, A.J.2    Castagnoli Jr., N.3
  • 48
    • 77957010982 scopus 로고
    • Citrate synthase
    • Srere, P. A. (1969). Citrate synthase. Methods Enzymol. 13, 3-11.
    • (1969) Methods Enzymol. , vol.13 , pp. 3-11
    • Srere, P.A.1
  • 49
    • 0024546234 scopus 로고
    • The role of environmental toxins in the etiology of Parkinson's disease
    • Tanner, C.M. (1989). The role of environmental toxins in the etiology of Parkinson's disease. Trends Neurosci. 12, 49-54.
    • (1989) Trends Neurosci. , vol.12 , pp. 49-54
    • Tanner, C.M.1
  • 51
    • 0025327731 scopus 로고
    • Unbiased stereological estimation of the number of neurons in the human hippocampus
    • West, M. J. and Gundersen, H. J. G. (1990). Unbiased stereological estimation of the number of neurons in the human hippocampus. J. Comp. Neurol. 296, 1-22.
    • (1990) J. Comp. Neurol. , vol.296 , pp. 1-22
    • West, M.J.1    Gundersen, H.J.G.2
  • 52
    • 0027194462 scopus 로고
    • New stereological methods for counting neurons
    • West, M. J. (1993). New stereological methods for counting neurons. Neurobiology of Aging, Vol. 14, pp. 275-285.
    • (1993) Neurobiology of Aging , vol.14 , pp. 275-285
    • West, M.J.1
  • 53
    • 2042432480 scopus 로고
    • Cytochrome oxidase from beef heart mitochondria
    • Wharton, D. C. and Tzagoloff, A. (1967). Cytochrome oxidase from beef heart mitochondria. Methods Enzymol. 10, 245-250.
    • (1967) Methods Enzymol. , vol.10 , pp. 245-250
    • Wharton, D.C.1    Tzagoloff, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.