-
1
-
-
0031731295
-
Tyrosine kinase inhibitors in cancer treatment
-
Traxler P (1998) Tyrosine kinase inhibitors in cancer treatment. Expert Opin Ther Pat 8, 1599-1625
-
(1998)
Expert Opin Ther Pat
, vol.8
, pp. 1599-1625
-
-
Traxler, P.1
-
2
-
-
0034193568
-
Protein-protein interactions define specificity in signal transduction
-
Pawson T & Nash P (2000) Protein-protein interactions define specificity in signal transduction. Genes Dev 14, 1027-1047
-
(2000)
Genes Dev
, vol.14
, pp. 1027-1047
-
-
Pawson, T.1
Nash, P.2
-
3
-
-
0034644539
-
Cell signalling by receptor tyrosine kinases
-
Schlessinger J (2000) Cell signalling by receptor tyrosine kinases. Cell 103, 211-225
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
4
-
-
0034614637
-
The hallmark of cancer
-
Hanahan D & Weinberg R A (2000) The hallmark of cancer. Cell 100, 57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
5
-
-
0034614490
-
Signaling-2000 and beyond
-
Hunter T (2000) Signaling-2000 and beyond. Cell 100, 113-127
-
(2000)
Cell
, vol.100
, pp. 113-127
-
-
Hunter, T.1
-
7
-
-
0027138356
-
The role of p21ras in receptor tyrosine kinase signaling
-
Medema R H & Bos J L (1993) The role of p21ras in receptor tyrosine kinase signaling. Crit Rev Oncog 4, 615-661
-
(1993)
Crit Rev Oncog
, vol.4
, pp. 615-661
-
-
Medema, R.H.1
Bos, J.L.2
-
8
-
-
0028895156
-
SH2 and SH3 domains: Potential targets for anti-cancer drug design
-
Smithgall T E (1995) SH2 and SH3 domains: potential targets for anti-cancer drug design. J Pharmacol Toxicol Methods 34, 125-132
-
(1995)
J Pharmacol Toxicol Methods
, vol.34
, pp. 125-132
-
-
Smithgall, T.E.1
-
9
-
-
0030072570
-
Vertebrate non-receptor protein-tyrosine kinase families
-
Neet K & Hunter T (1996) Vertebrate non-receptor protein-tyrosine kinase families. Genes Cells 1, 147-169
-
(1996)
Genes Cells
, vol.1
, pp. 147-169
-
-
Neet, K.1
Hunter, T.2
-
10
-
-
0037177880
-
Structure of the Carboxyl-terminal Src Kinase, Csk
-
Ogawa A, Takayama Y, Sakai H, Chong K T, Takeuchi S, Nakagawa A, Nada S, Okada M & Tsukihara T (2002) Structure of the Carboxyl-terminal Src Kinase, Csk. J Biol Chem 277, 14351-14354
-
(2002)
J Biol Chem
, vol.277
, pp. 14351-14354
-
-
Ogawa, A.1
Takayama, Y.2
Sakai, H.3
Chong, K.T.4
Takeuchi, S.5
Nakagawa, A.6
Nada, S.7
Okada, M.8
Tsukihara, T.9
-
11
-
-
0346850863
-
Identification of PSD-93 as a substrate for the Src-family tyrosine kinase Fyn
-
USA
-
Nada S, Shima T, Yanai H, Husi H, Grant S G N, Okada M & Akiyama T (2003) Identification of PSD-93 as a substrate for the Src-family tyrosine kinase Fyn. J Biol Chem (USA) 278, 47610-47621
-
(2003)
J Biol Chem
, vol.278
, pp. 47610-47621
-
-
Nada, S.1
Shima, T.2
Yanai, H.3
Husi, H.4
Grant, S.G.N.5
Okada, M.6
Akiyama, T.7
-
12
-
-
0141994730
-
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-Kinase/AKT cascades
-
Lu Y, Yu Q, Liu J H, Zhang J, Wang H , Koul D, McMurray J S, Fang X, Yung W K A, Siminovitch K A & Mills G B (2003) Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-Kinase/AKT cascades. J Biol Chem 278, 40057-40066
-
(2003)
J Biol Chem
, vol.278
, pp. 40057-40066
-
-
Lu, Y.1
Yu, Q.2
Liu, J.H.3
Zhang, J.4
Wang, H.5
Koul, D.6
McMurray, J.S.7
Fang, X.8
Yung, W.K.A.9
Siminovitch, K.A.10
Mills, G.B.11
-
13
-
-
0344736716
-
Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase
-
Lee S, Lin X, Nam N, Parang K & Sun G (2003) Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase. Proc Natl Acad Sci (USA) 100, 14707-14712
-
(2003)
Proc Natl Acad Sci (USA)
, vol.100
, pp. 14707-14712
-
-
Lee, S.1
Lin, X.2
Nam, N.3
Parang, K.4
Sun, G.5
-
14
-
-
0038267169
-
Functions of the activation loop in Csk protein-tyrosine kinase
-
Lin X, Lee S & Sun G (2003) Functions of the activation loop in Csk protein-tyrosine kinase. J Biol Chem 278, 24077
-
(2003)
J Biol Chem
, vol.278
, pp. 24077
-
-
Lin, X.1
Lee, S.2
Sun, G.3
-
15
-
-
0024240990
-
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors
-
Yaish P, Gazit A & Gilon C (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242, 933-935
-
(1988)
Science
, vol.242
, pp. 933-935
-
-
Yaish, P.1
Gazit, A.2
Gilon, C.3
-
16
-
-
0001182421
-
Protein kinase inhibitors: Structural determinants for target specificity
-
McMahon G, Sun L, Liang C & Tang C (1998) Protein kinase inhibitors: Structural determinants for target specificity. Curr Opin Drug Discov Dev 1, 131-146
-
(1998)
Curr Opin Drug Discov Dev
, vol.1
, pp. 131-146
-
-
McMahon, G.1
Sun, L.2
Liang, C.3
Tang, C.4
-
17
-
-
0031957684
-
Effect of tyrosine kinase inhibition on surfactant protein a gene expression during human lung development
-
Klein J M, DeWild L J & McCarthy T A (1998) Effect of tyrosine kinase inhibition on surfactant protein A gene expression during human lung development. Am J Physiol 274, 542-551
-
(1998)
Am J Physiol
, vol.274
, pp. 542-551
-
-
Klein, J.M.1
DeWild, L.J.2
McCarthy, T.A.3
-
18
-
-
0038718522
-
Developing inhibitors of the epidermal growth factor receptor for cancer treatment
-
Grunwald V & Hidalgo M (2003) Developing inhibitors of the epidermal growth factor receptor for cancer treatment. J Natl Cancer Inst 95, 851-867
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 851-867
-
-
Grunwald, V.1
Hidalgo, M.2
-
19
-
-
0036667387
-
Epidermal growth factor receptor tyrosine kinase inhibitors
-
Walking A E (2002) Epidermal growth factor receptor tyrosine kinase inhibitors. Curr Opin in Phamacol 2, 382-387
-
(2002)
Curr Opin in Phamacol
, vol.2
, pp. 382-387
-
-
Walking, A.E.1
-
20
-
-
0034788453
-
Tyrosine kinase inhibitors: -From rational design to clinical trials
-
Traxler P, Bold G, Buchdanger E, Caravatti G, Furet P, Manley P O, O'Reilly T, Wood J & Zimmermann J (2001) Tyrosine kinase inhibitors: -from rational design to clinical trials. Med Res Rev 21, 499-512
-
(2001)
Med Res Rev
, vol.21
, pp. 499-512
-
-
Traxler, P.1
Bold, G.2
Buchdanger, E.3
Caravatti, G.4
Furet, P.5
Manley, P.O.6
O'Reilly, T.7
Wood, J.8
Zimmermann, J.9
-
21
-
-
7144227965
-
Epidermal growth factor receptor and EGF-R mutations, function and possible role in clinical trials
-
Voldberg B R, Spang-Thomsen M & Palsen H S (1997) Epidermal growth factor receptor and EGF-R mutations, function and possible role in clinical trials. Ann Oncol 8, 1197-1206
-
(1997)
Ann Oncol
, vol.8
, pp. 1197-1206
-
-
Voldberg, B.R.1
Spang-Thomsen, M.2
Palsen, H.S.3
-
22
-
-
0035893560
-
Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-over-expressing breast cancer cells in vitro and in vivo
-
Moulder S L, Yakes F M, Muthuswamy S K, Bianco R, Simpson J F & Arteaga C L (2001) Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-over-expressing breast cancer cells in vitro and in vivo. Cancer Res 61, 8887-8895
-
(2001)
Cancer Res
, vol.61
, pp. 8887-8895
-
-
Moulder, S.L.1
Yakes, F.M.2
Muthuswamy, S.K.3
Bianco, R.4
Simpson, J.F.5
Arteaga, C.L.6
-
23
-
-
0036143027
-
Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast
-
Chan K C, Knox W F, Gee J M, Morris J, Nicholson R I, Potten C S & Bundred N J (2002) Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast. Cancer Res 62, 122-128
-
(2002)
Cancer Res
, vol.62
, pp. 122-128
-
-
Chan, K.C.1
Knox, W.F.2
Gee, J.M.3
Morris, J.4
Nicholson, R.I.5
Potten, C.S.6
Bundred, N.J.7
-
24
-
-
0034489914
-
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
-
Sirotnak F M, Zakowski M F, Miller V A, Scher H I & Kris M G (2000) Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin Cancer Res 6, 4885-4892
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4885-4892
-
-
Sirotnak, F.M.1
Zakowski, M.F.2
Miller, V.A.3
Scher, H.I.4
Kris, M.G.5
-
25
-
-
0036214044
-
The ErbB receptor family: A therapeutic target for cancer
-
Bono J S & Rowinsky E K (2002) The ErbB receptor family: a therapeutic target for cancer. Trends Mol Med (Suppl.) 8, 19-26
-
(2002)
Trends Mol Med (Suppl.)
, vol.8
, pp. 19-26
-
-
Bono, J.S.1
Rowinsky, E.K.2
-
26
-
-
0036362181
-
Why the epidermal growth factor receptor? The rationale for cancer therapy
-
Baselga J (2002) Why the epidermal growth factor receptor? The rationale for cancer therapy. The Oncologist (Suppl.) 7, 2-8
-
(2002)
The Oncologist (Suppl.)
, vol.7
, pp. 2-8
-
-
Baselga, J.1
-
27
-
-
15744363332
-
The role of VEGF in angiogenesis
-
Ferrara N & Gerber H P (2002) The role of VEGF in angiogenesis. Acta Haematol 106, 148-156
-
(2002)
Acta Haematol
, vol.106
, pp. 148-156
-
-
Ferrara, N.1
Gerber, H.P.2
-
28
-
-
0034978562
-
Deletion of the hypoxia response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
-
Oosthuyse B, Moons L, Strokebaum E, Beck H, Nuyens D, Brusselmans K, Van Dorpe J, Helling P, Gorselink M Heymans S, Theilmeier G, Dewerchin M, Laudenbach V, Vermylen P, Raat H, Acker T, Vleminckx V, Van Den Bosch L, Cashman N, Fujisawa H, Drost M R, Sciot R, Bruyninckx F, Hicklin D J, Ince C, Gressens P, Lupu F, Plate K H, Robberecht W, Herbert J M, Collen D & Carmeliet P (2001) Deletion of the hypoxia response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Grenet 28, 131-138
-
(2001)
Nat Grenet
, vol.28
, pp. 131-138
-
-
Oosthuyse, B.1
Moons, L.2
Strokebaum, E.3
Beck, H.4
Nuyens, D.5
Brusselmans, K.6
Van Dorpe, J.7
Helling, P.8
Gorselink, M.9
Heymans, S.10
Theilmeier, G.11
Dewerchin, M.12
Laudenbach, V.13
Vermylen, P.14
Raat, H.15
Acker, T.16
Vleminckx, V.17
Van Den Bosch, L.18
Cashman, N.19
Fujisawa, H.20
Drost, M.R.21
Sciot, R.22
Bruyninckx, F.23
Hicklin, D.J.24
Ince, C.25
Gressens, P.26
Lupu, F.27
Plate, K.H.28
Robberecht, W.29
Herbert, J.M.30
Collen, D.31
Carmeliet, P.32
more..
-
29
-
-
0035415663
-
SH2 domain inhibition: A problem solved?
-
Shakespeare W C (2001) SH2 domain inhibition: a problem solved? Curr Opin Chem Biol 5, 409-415
-
(2001)
Curr Opin Chem Biol
, vol.5
, pp. 409-415
-
-
Shakespeare, W.C.1
-
30
-
-
0027487087
-
Vascular endothelial growth factor
-
Ferrara N (1993) Vascular endothelial growth factor. Trends Cardiovasc Med 3, 244-250
-
(1993)
Trends Cardiovasc Med
, vol.3
, pp. 244-250
-
-
Ferrara, N.1
-
31
-
-
1442299164
-
Effects of PTK787/ZK222584, a tyrosine kinase inhibitor, on the growth of poorly differentiated thyroid carcinoma: An animal study
-
Schoenberger J, Grimm D, Kossmehl P, Infanger M, Kurth E & Eillies C (2004) Effects of PTK787/ZK222584, a tyrosine kinase inhibitor, on the growth of poorly differentiated thyroid carcinoma: an animal study. Endocrinology 145, 1031-1038
-
(2004)
Endocrinology
, vol.145
, pp. 1031-1038
-
-
Schoenberger, J.1
Grimm, D.2
Kossmehl, P.3
Infanger, M.4
Kurth, E.5
Eillies, C.6
-
32
-
-
0030561092
-
The role of VEGF in blood vessel formation
-
Breier G & Risau W (1996) The role of VEGF in blood vessel formation. TIBC 6, 454-456
-
(1996)
TIBC
, vol.6
, pp. 454-456
-
-
Breier, G.1
Risau, W.2
-
33
-
-
0029166443
-
Regulation of the expression of VEGF/VPS and it's receptors. Role in tumor angiogenesis
-
Koelch W, Martiny-Baron G, Kieser A & Marme D (1995) Regulation of the expression of VEGF/VPS and it's receptors. Role in tumor angiogenesis. Breast Cancer Res Treat 36, 139-155
-
(1995)
Breast Cancer Res Treat
, vol.36
, pp. 139-155
-
-
Koelch, W.1
Martiny-Baron, G.2
Kieser, A.3
Marme, D.4
-
34
-
-
0034655182
-
PTK787/ZK222584, a novel and potent inhibitor of vascular endothelial growth factor induced responses and tumor after oral administration
-
Wood J M, Bold G, Buchdunger E, Cozens R, Ferrari S, Frei J, Hofmann F, Mestan J, Mett H, O'Reilly T, Persohn E, Rosel J, Schnell C, Stover D, Theuer A, Towbin H, Wenger F, Woods-Cook K, Menrad A, Siemeister G, Schirner M, Thierauch K H, Schneider M R, Drevs J, Martiny-Baron G, Totzke F & Marme D (2000) PTK787/ZK222584, a novel and potent inhibitor of vascular endothelial growth factor induced responses and tumor after oral administration. Cancer Res 60, 2178-2189
-
(2000)
Cancer Res
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
Cozens, R.4
Ferrari, S.5
Frei, J.6
Hofmann, F.7
Mestan, J.8
Mett, H.9
O'Reilly, T.10
Persohn, E.11
Rosel, J.12
Schnell, C.13
Stover, D.14
Theuer, A.15
Towbin, H.16
Wenger, F.17
Woods-Cook, K.18
Menrad, A.19
Siemeister, G.20
Schirner, M.21
Thierauch, K.H.22
Schneider, M.R.23
Drevs, J.24
Martiny-Baron, G.25
Totzke, F.26
Marme, D.27
more..
-
35
-
-
0034016273
-
Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation
-
Yano S, Herbst R S, Shinohara H, Knighton B, Bucana C D, Killion J J, Wood J & Fidler I J (2000) Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation. Clin Cancer Res 6, 955-965
-
(2000)
Clin Cancer Res
, vol.6
, pp. 955-965
-
-
Yano, S.1
Herbst, R.S.2
Shinohara, H.3
Knighton, B.4
Bucana, C.D.5
Killion, J.J.6
Wood, J.7
Fidler, I.J.8
-
36
-
-
0034145605
-
Inhibition of malignant ascites and growth of ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases
-
Xu L, Yoneda J, Herrera C, Wood J, Killion J J & Fidler I J (2000) Inhibition of malignant ascites and growth of ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Int J Oncol 16, 445-454
-
(2000)
Int J Oncol
, vol.16
, pp. 445-454
-
-
Xu, L.1
Yoneda, J.2
Herrera, C.3
Wood, J.4
Killion, J.J.5
Fidler, I.J.6
-
37
-
-
16844382092
-
A phase I/II trial of single-agent PTK 787/ZK222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM)
-
th ASCO Annual Meeting; New Orleans, LA. June 5-8, 2004 Abstract No. 1512
-
(2004)
th ASCO Annual Meeting; New Orleans, LA. June 5-8, 2004 Abstract No. 1512
-
-
Conrad, C.1
Friedman, H.2
Reardon, D.3
Provenzale, J.4
Jackson, E.5
Serajuddin, H.6
Laurent, D.7
Chen, B.8
Yung, W.K.A.9
-
38
-
-
0036531923
-
Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer
-
Baker C H, Solorzano C C & Fidler I J (2002) Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer. Cancer Res 62, 1996-2003
-
(2002)
Cancer Res
, vol.62
, pp. 1996-2003
-
-
Baker, C.H.1
Solorzano, C.C.2
Fidler, I.J.3
-
39
-
-
0037530506
-
Potential role of platelets in endothelial damage observed during treatment with Cisplatin, Gemcitabine, and the angiogenesis inhibitor SU5416
-
Kuenen B C, Levi M, Meijers J C M, Van Hinsbergh V W M, Berkhof J, Kakkar A K, Hoekman K & Pinedo H M (2003) Potential role of platelets in endothelial damage observed during treatment with Cisplatin, Gemcitabine, and the angiogenesis inhibitor SU5416. J Clin Oncol 21, 2192-2198
-
(2003)
J Clin Oncol
, vol.21
, pp. 2192-2198
-
-
Kuenen, B.C.1
Levi, M.2
Meijers, J.C.M.3
Van Hinsbergh, V.W.M.4
Berkhof, J.5
Kakkar, A.K.6
Hoekman, K.7
Pinedo, H.M.8
-
40
-
-
0001101835
-
Antiangiogenic effect by SU5416 is partly attributable to inhibition of Fit-1 receptor signaling
-
Itokawa T, Nokihara H, Nishioka Y, Sone S, Iwamoto Y, Yamada Y, Cherrington J, McMahon G, Shibuya M, Kuwano M & Ono M (2002) Antiangiogenic effect by SU5416 is partly attributable to inhibition of Fit-1 receptor signaling. Mol Cancer Ther 1, 295-302
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 295-302
-
-
Itokawa, T.1
Nokihara, H.2
Nishioka, Y.3
Sone, S.4
Iwamoto, Y.5
Yamada, Y.6
Cherrington, J.7
McMahon, G.8
Shibuya, M.9
Kuwano, M.10
Ono, M.11
-
41
-
-
1642453748
-
Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma
-
Zangari M, Anaissie E, Stopeck A, Morimoto A, Tan N, Lancet J, Cooper M, Hannah A, Garcia-Manero G, Faderl S, Kantarjian H, Cherrington J, Albitar M & Giles F J (2004) Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma. Clin Cancer Res 1, 88-95
-
(2004)
Clin Cancer Res
, vol.1
, pp. 88-95
-
-
Zangari, M.1
Anaissie, E.2
Stopeck, A.3
Morimoto, A.4
Tan, N.5
Lancet, J.6
Cooper, M.7
Hannah, A.8
Garcia-Manero, G.9
Faderl, S.10
Kantarjian, H.11
Cherrington, J.12
Albitar, M.13
Giles, F.J.14
-
42
-
-
0038327794
-
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma
-
Kuenen B C, Tabernero J, Baselga J, Cavalli F, Pfanner E, Conte P F, Seeber S, Madhusudan S, Deplanque G, Huisman H, Scigalla P, Hoekman K & Harris A L (2003) Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. Clin Cancer Res 9, 1648-1655
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1648-1655
-
-
Kuenen, B.C.1
Tabernero, J.2
Baselga, J.3
Cavalli, F.4
Pfanner, E.5
Conte, P.F.6
Seeber, S.7
Madhusudan, S.8
Deplanque, G.9
Huisman, H.10
Scigalla, P.11
Hoekman, K.12
Harris, A.L.13
-
43
-
-
0035810145
-
Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Goldman J M & Melo J V (2001) Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344, 1084-1086
-
(2001)
N Engl J Med
, vol.344
, pp. 1084-1086
-
-
Goldman, J.M.1
Melo, J.V.2
-
44
-
-
0033565561
-
The biology of chronic myeloid leukemia
-
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R & Kantarjian H M (1999) The biology of chronic myeloid leukemia. N Engl J Med 341, 164-172
-
(1999)
N Engl J Med
, vol.341
, pp. 164-172
-
-
Faderl, S.1
Talpaz, M.2
Estrov, Z.3
O'Brien, S.4
Kurzrock, R.5
Kantarjian, H.M.6
-
45
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker B J, Talpaz M, Resta D J, Peng B, Buchdunger E, Ford J M, Lydon N B, Kantarjian H, Capdeville R, OhnoJones S & Sawyers C L (2001) Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344, 1031-1037
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
OhnoJones, S.10
Sawyers, C.L.11
-
46
-
-
0033614446
-
Medical Progress: Chronic myeloid leukaemia
-
Sawyers C L (1999) Medical Progress: Chronic myeloid leukaemia. N Engl J Med 340, 1330-1340
-
(1999)
N Engl J Med
, vol.340
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
47
-
-
0031038536
-
ABC of clinical haematology: Chronic myeloid leukemia
-
Goldman J (1997) ABC of clinical haematology: Chronic myeloid leukemia. Br Med J 314, 657-664
-
(1997)
Br Med J
, vol.314
, pp. 657-664
-
-
Goldman, J.1
-
48
-
-
0036094117
-
Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia
-
Cohen M H, Williams G, Johnson J R, Duan J, Gobburu J, Rahman A, Benson K, Leighton J, Kim S K, Wood R, Rothmann M, Chen G, U Khin M, Staten A M & Pazdur R (2002) Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res 8, 935-942
-
(2002)
Clin Cancer Res
, vol.8
, pp. 935-942
-
-
Cohen, M.H.1
Williams, G.2
Johnson, J.R.3
Duan, J.4
Gobburu, J.5
Rahman, A.6
Benson, K.7
Leighton, J.8
Kim, S.K.9
Wood, R.10
Rothmann, M.11
Chen, G.12
U Khin, M.13
Staten, A.M.14
Pazdur, R.15
-
49
-
-
0035496899
-
Chronic myeloid leukemia: Current treatment options
-
Goldman J M & Druker B J (2001) Chronic myeloid leukemia: Current treatment options. Blood 98, 2039-2042
-
(2001)
Blood
, vol.98
, pp. 2039-2042
-
-
Goldman, J.M.1
Druker, B.J.2
-
50
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H M, Sawyers C, Hochhaus A, Guilhot F, Schifer C, Gambacorti-Passerini C, Niederweiser D, Resta D, Capdeville R, Zoellner U, Talpaz M & Druker B (2002) Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 346, 645-652
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.M.1
Sawyers, C.2
Hochhaus, A.3
Guilhot, F.4
Schifer, C.5
Gambacorti-Passerini, C.6
Niederweiser, D.7
Resta, D.8
Capdeville, R.9
Zoellner, U.10
Talpaz, M.11
Druker, B.12
-
51
-
-
0037438467
-
Dose escalation of imatinib mesylate can overcome resistance to standard dose therapy in patients with chronic myelogenous leukemia
-
Kantarjian H M, Talpaz M, O'Brien S, Giles F, Gracia-Manero G, Fadrel S, Thomas D, Shan J, Rios M B & Cortes J (2003) Dose escalation of imatinib mesylate can overcome resistance to standard dose therapy in patients with chronic myelogenous leukemia. Blood 101, 473-475
-
(2003)
Blood
, vol.101
, pp. 473-475
-
-
Kantarjian, H.M.1
Talpaz, M.2
O'Brien, S.3
Giles, F.4
Gracia-Manero, G.5
Fadrel, S.6
Thomas, D.7
Shan, J.8
Rios, M.B.9
Cortes, J.10
-
52
-
-
0037336773
-
Gleevec: Tailoring to fit
-
May Thomas S (2003) Gleevec: Tailoring to fit. Drug Disc Today 8, 188-189
-
(2003)
Drug Disc Today
, vol.8
, pp. 188-189
-
-
May Thomas, S.1
-
53
-
-
0036667385
-
Protein tyrosine kinase inhibitors: New treatment modalities?
-
Fabbro D, Parkinson D & Matter A (2002) Protein tyrosine kinase inhibitors: new treatment modalities? Curr Opin in Pharmacol 2, 374-381
-
(2002)
Curr Opin in Pharmacol
, vol.2
, pp. 374-381
-
-
Fabbro, D.1
Parkinson, D.2
Matter, A.3
-
54
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker B J, Tamura S, Buchdunger E, Ohno S, Segal G M, Fanning S, Zimmermann J & Lydon B (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nature Med 2, 561-566
-
(1996)
Nature Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lydon, B.8
-
55
-
-
0035810142
-
Activity of a specific inhibitor of the Bcr-Abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with Philadelphia chromosome
-
Druker B J, Sawyers C L, Kantarjian H, Resta D J, Reese S F, Ford J M, Cadeville R & Talpez M (2001) Activity of a specific inhibitor of the Bcr-Abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with Philadelphia chromosome. N Engl Med 344, 1038-1042
-
(2001)
N Engl Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
Cadeville, R.7
Talpez, M.8
-
57
-
-
0035960428
-
Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
-
Van Oosterom A T, Judson T, Verweij J, Stroobants S, Donato di Paola E, Dimitrijevic S, Martens M, Webb A, Sciot R, Van Glabbeke M, Silberman S & Nielsen O S (2001) Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 358, 1421-1423
-
(2001)
Lancet
, vol.358
, pp. 1421-1423
-
-
Van Oosterom, A.T.1
Judson, T.2
Verweij, J.3
Stroobants, S.4
Donato Di Paola, E.5
Dimitrijevic, S.6
Martens, M.7
Webb, A.8
Sciot, R.9
Van Glabbeke, M.10
Silberman, S.11
Nielsen, O.S.12
-
58
-
-
84866319452
-
STI 571, an active drug in metastatic gastro intestinal stromal tumors (GIST), an EORTC phase I study
-
th Annual Meeting; May 12-15, 2001
-
th Annual Meeting; May 12-15, 2001; San Francisco, CA. Abstract No. 2. Available at: http://www.asco.org
-
(2001)
San Francisco, CA. Abstract No. 2
-
-
Van Oosterom, A.T.1
-
59
-
-
10744228340
-
Imatinib mesylate therapy of chronic myeloid leukemia resistant or intolerant to interferon: Results and prognostic factors for response and progression-free survival in 150 patients
-
Cerrantes F, Hernandez-Boluda J C, Steegmann J L, Conde E, Alvarez-Larran A, Lopez-Jimenez J, Osorio S, Villalon L, Camos M, Gracia-Conde J & Odriozola J (2003) Imatinib mesylate therapy of chronic myeloid leukemia resistant or intolerant to interferon: results and prognostic factors for response and progression-free survival in 150 patients. Haematologica 88, 1117-1122
-
(2003)
Haematologica
, vol.88
, pp. 1117-1122
-
-
Cerrantes, F.1
Hernandez-Boluda, J.C.2
Steegmann, J.L.3
Conde, E.4
Alvarez-Larran, A.5
Lopez-Jimenez, J.6
Osorio, S.7
Villalon, L.8
Camos, M.9
Gracia-Conde, J.10
Odriozola, J.11
-
60
-
-
10744231480
-
Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-α
-
Cortes J, Giles F, O'Brien S, Thomas D, Garcia-Manero G, Rios M B, Faderl S, Verstovsek S, Ferrajoli A, Freireich E J, Talpaz M & Kantarjian H (2003) Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-α. Blood 102, 83-86
-
(2003)
Blood
, vol.102
, pp. 83-86
-
-
Cortes, J.1
Giles, F.2
O'Brien, S.3
Thomas, D.4
Garcia-Manero, G.5
Rios, M.B.6
Faderl, S.7
Verstovsek, S.8
Ferrajoli, A.9
Freireich, E.J.10
Talpaz, M.11
Kantarjian, H.12
-
61
-
-
84866325617
-
-
East Hanover, N J: Novartis Pharmacteuticals Corporation; 2002
-
Novartis Package literature for Gleevec. East Hanover, N J (2002): Novartis Pharmacteuticals Corporation; 2002. Available at: http://www.pharma.us. novartis.com/product/pi/pdf/Gleevec.pdf
-
(2002)
Novartis Package Literature for Gleevec
-
-
-
62
-
-
0348140591
-
Mechanisms and implications of imatinib resistance mutations in Bcr-Abl
-
Nardi V, Azam M & Daley G (2004) Mechanisms and implications of imatinib resistance mutations in Bcr-Abl. Curr Opin in Hematol 11, 35-43
-
(2004)
Curr Opin in Hematol
, vol.11
, pp. 35-43
-
-
Nardi, V.1
Azam, M.2
Daley, G.3
-
63
-
-
0141788346
-
STI-571: An anticancer protein-tyrosine kinase inhibitor
-
Roskoski R (2003) STI-571: an anticancer protein-tyrosine kinase inhibitor. Biochem and Biophy Res Comm 309, 709-717
-
(2003)
Biochem and Biophy Res Comm
, vol.309
, pp. 709-717
-
-
Roskoski, R.1
-
64
-
-
0036850514
-
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
-
Hochhaus A, Kreil S, Corbin A S, La Rosee P, Muller M C, Lahaye T, Hanfstein B, Schoch C, Cross N C, Berger U, Gschaidmeier H, Druker B J & Hehlmann R (2002) Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 16, 2190-2196
-
(2002)
Leukemia
, vol.16
, pp. 2190-2196
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.S.3
La Rosee, P.4
Muller, M.C.5
Lahaye, T.6
Hanfstein, B.7
Schoch, C.8
Cross, N.C.9
Berger, U.10
Gschaidmeier, H.11
Druker, B.J.12
Hehlmann, R.13
-
65
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
Branford S, Rudzki Z, Walsh S, Grigg A, Arthur C, Kerry T, Herrmann R, Lynch K P & Hughes T P (2002) High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99, 3472-3475
-
(2002)
Blood
, vol.99
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
Grigg, A.4
Arthur, C.5
Kerry, T.6
Herrmann, R.7
Lynch, K.P.8
Hughes, T.P.9
-
66
-
-
0036682481
-
Several types of mutations of the AbI gene can be found in chronic myeloid leukemia patients resistant to STI 571, and they can pre- exist to the onset of treatment
-
Roche-Lestienne C, Soenen-Cornu V, Grardel -Duflos N, Lai J L, Philippe N, Facon T, Fenaux P & Preudhomme C (2002) Several types of mutations of the AbI gene can be found in chronic myeloid leukemia patients resistant to STI 571, and they can pre- exist to the onset of treatment. Blood 100, 1014-1018
-
(2002)
Blood
, vol.100
, pp. 1014-1018
-
-
Roche-Lestienne, C.1
Soenen-Cornu, V.2
Grardel -Duflos, N.3
Lai, J.L.4
Philippe, N.5
Facon, T.6
Fenaux, P.7
Preudhomme, C.8
-
67
-
-
0036678472
-
Clinical resistance to the kinase inhibitor STI571 in chronic myeloid leukemia by mutation of Tyr-252 in the Abl kinase domain P-loop
-
Roumiantsev S, Shah N P, Gorre M E, Nicoll J, Brasher B B, Swayers C L & Van Etten R A (2002) Clinical resistance to the kinase inhibitor STI571 in chronic myeloid leukemia by mutation of Tyr-252 in the Abl kinase domain P-loop. Proc Natl Acad Sci (USA) 99, 10700-10705
-
(2002)
Proc Natl Acad Sci (USA)
, vol.99
, pp. 10700-10705
-
-
Roumiantsev, S.1
Shah, N.P.2
Gorre, M.E.3
Nicoll, J.4
Brasher, B.B.5
Swayers, C.L.6
Van Etten, R.A.7
-
68
-
-
0001686739
-
Multiple BCR-ABL Kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah N P, Nicoll J, Nagar B, Gorre M E, Paquette R L, Kuriyan J & Swayers C L (2002) Multiple BCR-ABL Kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2, 117-125
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.2
Nagar, B.3
Gorre, M.E.4
Paquette, R.L.5
Kuriyan, J.6
Swayers, C.L.7
-
69
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
-
Talpaz M, Silver R T, Druker B J, Goldman J M, Gambacorti-Passerini C, Guilhot F, Schiffer C A, Fischer T, Deininger M W, Lennard A L, Hochhaus A, Ottmann O G, Gratwohl A, Baccarani M, Stone R, Tura S, Mahon F X, Fernandes-Reese S, Gathmann I, Capdeville R, Kantarjian H M & Sawyers C L (2002) Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 99, 1928-1937
-
(2002)
Blood
, vol.99
, pp. 1928-1937
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
Goldman, J.M.4
Gambacorti-Passerini, C.5
Guilhot, F.6
Schiffer, C.A.7
Fischer, T.8
Deininger, M.W.9
Lennard, A.L.10
Hochhaus, A.11
Ottmann, O.G.12
Gratwohl, A.13
Baccarani, M.14
Stone, R.15
Tura, S.16
Mahon, F.X.17
Fernandes-Reese, S.18
Gathmann, I.19
Capdeville, R.20
Kantarjian, H.M.21
Sawyers, C.L.22
more..
-
70
-
-
15744369138
-
-
Novartis Pharmaceuticals Canada Inc., Dorval, Quebec (PI issued 09/2001) reviewed 10/2001
-
Product Information: Gleevec™, imatinib mesylate. Novartis Pharmaceuticals Canada Inc., Dorval, Quebec (PI issued 09/2001) reviewed 10/2001
-
Product Information: Gleevec™, Imatinib Mesylate
-
-
-
71
-
-
0034951384
-
STI571: Targeting Bcr-Abl as therapy for CML (2001)
-
Mauro M J & Druker B J (2001) STI571: Targeting Bcr-Abl as therapy for CML (2001) The Oncologist 6, 233-238
-
(2001)
The Oncologist
, vol.6
, pp. 233-238
-
-
Mauro, M.J.1
Druker, B.J.2
|