In situ product removal as a tool for bioprocessing

Bio/Technology

Volumn 11, Issue 9, 1993, Pages 1007-1012

  Freeman, Amihay ^a   Woodley, John M ^b   Lilly, Malcolm D ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOREACTOR; BIOTECHNOLOGY; BIOTRANSFORMATION; CELL CULTURE; CULTURE MEDIUM; HYDROPHOBICITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; REVIEW; SURFACE CHARGE; TECHNIQUE; VOLATILIZATION;

BIOTECHNOLOGY; CHEMISTRY, PHYSICAL; PHARMACEUTICAL PREPARATIONS;

EID: 15744378134     PISSN: 0733222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0993-1007     Document Type: Article

References (107)

1. Mattiasson, B. and Holst, O. (Eds.). 1991. Extractive Bioconversions. Marcel Dekker Inc. N.Y.
2. Roffler, S. R., Blanch, H. W. and Wilke, C. R. 1984. In situ recovery of fermentation products. Trends Biotechnol. 2:129-36.
3. Mattiasson, B. and Larsson, M. 1985. Extractive bioconversions with emphasis on solvent production. Biotechnology and Genetic Engineering Reviews 3:137-174.
4. Daugulis, A. J. 1988. Integrated reaction and product recovery in bioreactor systems. Biotechnol. Prog. 4:113-122.
5. Szathmary, S. and Grandics, P. 1990. Bioreactor integration with downstream processing. Bio/Technology 8:924-925.
6. Wecker, M. S. and Zall, R. R. 1987. Fermentation strategies: acetaldehyde or ethanol? Process Biochem. 22:135-138.
7. Nishri, Y. and Freeman, A. 1992. Continuous production of acetaldehyde by immobilized yeast with in situ product trapping: comparison of alcohol dehydrogenase and alcohol oxidase routes. Appl. Biochem. Biotechnol. In press.
8. Swartz, R. W. 1985. Penicillins, p. 8-47. In: Comprehensive Biotechnology, Vol. 3. Moo-Young, M. (Ed.). Pergamon, Oxford, UK.
9. Ingram, L. O. and Buttke, T, M. 1984. Effect of alcohols on microorganisms. Adv. Microb. Physiol. 25:254-300.
10. Morcira, A. R., Ulmer, D. C. and Linden, J. C. 1981. Butanol toxicity in the butyric fermentation. Biotechnol. Bioeng. Symp. 11:567-579, Wiley, N.Y.
11. 1-hydrocortisone dehydrogenation with in situ product recovery. Enzyme Microb. Technol. 13:869-872.
12. Nienow, A. W. 1990. Agitators for mycelial fermentations. Trends Biotechnol. 8:224-233.
13. Lewis, V. P. and Yang, S. T. 1992. A novel extractive fermentation process for propionic acid production from whey lactose. Biotechnol. Prog. 8:104-110.
14. Laane, C., Boeren, S., Hilhorst, R. and Veeger, C. 1987. Optimization of biocatalysis in organic media, p. 65-84. In: Biocatalysis in Organic Media. Laane, C., Tramper, J. and Lilly, M. D. (Eds.). Elsevier, Amsterdam.
15. Sandquist, J., Blanch, H. W. and Wilke, C. R. 1991. Vacuum fermentation, p. 237-258. In: Extractive Bioconversions. Mattiasson, B. and Holst, O. (Eds.). Marcel Dekker, N.Y.
16. Groot, W. J., van der Lans, R. G. J. M. and Luyben, K. Ch. A. M. 1992. Technologies for butanol recovery integrated with fermentations. Process Biochem. 27:61-75.
17. Strathmann, H. and Gudernatsch, W. 1991. Continuous removal of ethanol from bioreactor by pervaporation, p. 67-89. In: Extractive Bioconversions. Mattiasson, B. and Holst, O. (Eds.). Marcel Dekker, N.Y.
18. Roffler, S. R., Randolph, T. W., Miller, D. A., Blanch, H. W. and Prausnitz, J. M. 1991. Extractive bioconversions with nonaqueous solvents, p. 133-172. In: Extractive Bioconversions. Mattiasson, B. and Holst, O. (Eds.). Marcel Dekker, N.Y.
19. Kaul, R. and Mattiasson, B. 1991. Extractive bioconversions in aqueous two phase systems, p. 173-188. In: Extractive Bioconversions. Mattiasson, B. and Holst, O. (Eds.). Marcel Dekker, N.Y.
20. Belfort, G. 1989. Membranes and bioreactors: A technical challenge in biotechnology. Biotechnol. Bioeng. 33:1047-1066.
21. Chang, H. N. 1987. Membrane bioreactors. Biotech. Adv. 5:129-145.
22. Holst, O. and Mattiasson, B. 1991. Cultivation using membrane filtration and cell recycling, p. 11-26. In: Extractive Bioconversions, Mattiasson, B. and Holst, O. (Eds.). Marcel Dekker, N.Y.
23. Linardos, T. I., Kalogerakis, N. and Behie, L. A. 1992. Monoclonal antibody production in dialyzed continuous suspension culture. Biotechnol. Bioeng. 39:504-510.
24. Duff, S. J. B. and Murray, W. D. 1988. Production of flavor aldehydes using nongrowing whole cells of Pichia pastoris. Annal. N.Y. Acad. Sci. 542:428-433.
25. Fujii, M. and Taniguchi, M. 1991. Application of reversibly soluble polymers in bioprocessing. Trends Biotechnol. 9:191-196.
26. Shity, H. and Bar, R. 1992. New approach for selective separation of dilute products from simulated Clostridial fermentation broths using cyclodextrins. Biotechnol. Bioeng. 39:462-466.
27. Holst, O. and Mattiasson, B. 1991. Solid sorbents used in extractive bioconversion processes, p. 189-205. Extractive Bioconversions, Mattiasson, B. and Holst, O. (Eds.). Marcel Dekker, N.Y.
28. Wang, H. Y. 1983. Integrating biochemical separation and purification steps in fermentation processes. Annal. N.Y. Acad. Sci. 413:313-321.
29. Wang, H. Y., Palanki, S. and Hyatt, G. S. 1989. Application of affinity adsorption in thienamycin fermentation. App. Microbiol Biotechnol. 30:115-119.
30. Mitsuda, S., Matsuda, Y., Kobayashi, N., Suzuki, A., Itagaki, Y., Kumazawa, E., Highashio, K. and Kawanishi, G. 1991. Tissue plasminogen activator (t-PA) production by human fibroblasts using a bioreactor with t-PA adsorption column. Bioprocess Eng. 7:137-140.
31. Matsumura, M. 1991. Perstraction, p. 91-131. In: Extractive Bioconversions. Mattiasson, B. and Holst, O. (Eds.). Marcel Dekker, N.Y.
32. Seevaratnam, S., Holst, O., Hjöleifsdottir, S. and Mattiasson, B. Extractive bioconversion for lactic acid production using solid sorbent and organic solvent. Bioprocess Eng. 6:35-41.
33. Shabtai, Y., Chaimovitz, S., Freeman, A., Katchalski-Katzir, E., Linder, C, Nemas, M., Perry, M. and Kedem, O. 1991. Continuous ethanol production by immobilized yeast reactor coupled with membrane pervaporation unit. Biotechnol. Bioeng. 38:869-876.
34. Yabannavar, V. M. and Wang, D. I. C. 1991. Strategies for reducing solvent toxicity in extractive fermentation. Biotechnol. Bioeng. 37:716-722.
35. Friedl, A., Qureshi, N. and Maddox, I. S. 1991. Continous acetone-butanol-ethanol (ABE) fermentation using immobilized cells of Clostridium aceto-butylicum in a packed bed reactor and integration with product removal by pervaporation. Biotechnol. Bioeng. 38:518-527.
36. Groot, W. J., den Reyer, M. C. H., Baart de la Faille, T., van der Lans, R. G. J. M. and Luyben, K. Ch. A. M. 1991. Integration of pervaporation and continuous butanol fermentation with immobilized cells. Chem. Eng. J. 46:B1-B10.
37. Davison, B. H. and Scott, C. D. 1992. A proposed biparticle fluidized-bed for lactic acid fermentation and simultaneous adsorption. Biotechnol. Bioeng. 39:365-368.
38. Kobayashi, T. 1991. Integration of reaction with product recovery in bioreactor systems. Annal. N.Y. Acad. Sci. 613:248-254.
39. Roffler, S. R., Wilke, C. R. and Blanch, H. W. 1988. Design and mathematical description of differential contactors used in extractive fermentations. Biotechnol. Bioeng. 32:192-204.
40. Park, C. H., Okos, M. R. and Wankat, P. 1991. Acetone butanol ethanol (ABE) fermentation and simultaneous separation in a trickled bed reactor. Biotechnol. Prog. 7:185-194.
41. Ennis, B. M., Quershi, N. and Maddox, I. S. 1987. In line toxic product removal during solvent production by continuous fermentation using immobilized Clostridium acetobutylicum. Enzyme Microb. Technol. 9:672-675.
42. Matsumura, M., Thkehara, S. and Kataoka, H. 1992. Continuous butanol/isopropanol fermentation in down-flow column reactor coupled with pervaporation using supported liquid membrane. Biotechnol. Bioeng. 39:148-156.
43. Lopez, J. L., Matson, S. L., Stanley, T. J. and Quinn, J. 1991. Liquid-liquid extractive membrane reactors, p. 27-66. In: Extractive Bioconversions. Mattiasson, B. and Holst, O. (Eds.). Marcel Dekker, N.Y.
44. Shukla, R., Kang, W. and Sirkar, K. K. 1989. Acetone-butanol-ethanol (ABE) production in a novel hollow fiber fermentor-extractor. Biotechnol. Bioeng. 34:1158-1166.
45. Marques, P. S. S., Passarinho, P. C. L. V., Cabral, J. M. S., Novais, J. M. and Kennedy, J. F. 1989. Extractive fermentation of ethanol using entrapped and adsorbed Saccharomyces bayanus cells. Int. Ind. Biotechnol. 9:20-24.
46. Busche, R. M. 1991. Extractive fermentation of acetic acid. App. Biochem. Biotechnol. 28/29:605-622.
47. Yabannavar, V. M. and Wang, D. I. C. 1991. Extractive fermentation for lactic acid production. Biotechnol. Bioeng. 37:1095-1100.
48. Leay, L., Eberhardt, J. J., Allen, B. R., Scott, C. D. and Davison, B. H. 1990. Improved production of ethanol and N-butanol in immobilized cell bioreactors, p. 539-543. In: Physiology of Immobilized Cells, de Bont, J. A. M., Visser, J., Mattiasson, B. and Tramper, J. (Eds.). Elsevier, Amsterdam.
49. Diaz, M. 1988. Three phase extractive fermentation. Trends Biotechnol. 6:126-130.
50. Persson, I., Stalbrand, H., Tjreld, F. and Hahn-Hagerdal, B. 1991. Semicontinous production of cellulytic enzymes with Trichoderma reesei Rutgers C30 in an aqueous two phase system. Appl. Biochem. Biotechnol. 27:37-43.
51. Kang, W., Shukla, R. and Sirkar, K. K. 1990. Ethanol production in a microporous hollow-fiber-based extractive fermentor with immobilized yeast. Biotechnol. Bioeng. 36:826-833.
52. Minier, M., Frateloup, R., Blanc-Ferras, E. and Goma, G. 1990. Extractive acetonobutylic fermentation by coupling ultrafiltration and distillation. Biotechnol. Bioeng. 35:861-869.
53. Nomura, Y., Iwahara, M. and Hongo, M. 1987. Acetic acid production by an electrodialysis fermentation method with a computerized control system. Appl. Environ. Microbiol. 54:137-142.
54. Payne, G. F. and Wang, H. Y. 1989. The effect of feedback regulation and in situ product removal on the conversion of sugar to cycloheximide by Streptomyces griseus. Arch. Microbiol. 151:331-335.
55. Groot, W. J. and Luyben, K. Ch. A. M. 1986. In situ product recovery by adsorption in the butanol/isopropanol batch fermentation. Appl. Microbiol. Biotechnol. 25:29-31.
56. Asada, M. and Shuler, M. L. 1989. Stimulation of ajmalicine production and excretion from Catharantus roseus: effects of adsorption in situ, elicitons and alginate immobilization. App. Microbiol. Biotechnol. 30:475-481.
57. Takamatsu, S. and Ryu, D. D. Y. 1988. Recirculating bioreactor-separator system for simultaneous biotransformation and recovery of product: Immobilized L-aspartate /3-decarboxylase reactor system. Biotechnol. Bioeng. 32:184-191.
58. Dykstra, K. H., Li, X.-M. and Wang, H. Y. 1988. Computer modeling of antibiotic fermentation with on-line product removal. Biotechnol. Bioeng. 32:356-362.
59. van der Wielen, L. A. M., Potters, J. J. M., Straathof, A. J. J. and Luyben, K. Ch. A. M. 1990. Integration of bioconversion and continuous product separation by means of countercurrent adsorption. Chem. Eng. Sci. 45:2397-2404.
60. Davison, B. H. and Thompson, J. E. 1992. Simultaneous fermentation and separation of lactic acid in a biparticle fluidized-bed bioreactor. Appl. Biochem. Biotechnol. 34/35:431-439.
61. Reschke, M. and Schugerl, K. 1986. Simulation of the continuous reactive extraction of penicillin G in a Karr column. Chem. Eng. J. 32:B1-B5.
62. Hecht, V., Vorlop, J., Kalbitz, H., Gerth, K. and Lehmann, J. 1987. Vortex chamber for in situ recovery of the antibiotic Myxovirescin A in continuous cultivation. Biotech. Bioeng. 24:222-227.
63. Traeger, M., Buse, R., Mueller, U. and Onken, U. 1989. Non ionic surfactants as in situ extraction solvents for hydrophobic fermentation products. Dechema Biotechnol. Conf. 3(B): 1093-1096.
64. Eiki, H., Gushima, H., Saito, T., Ishida, H., Oka, Y. and Osono, T. 1988. Product inhibition and its removal on josamycin fermentation by Streptomyces narbonensis var. josamyaticus. J. Ferment. Technol. 66:559-565.
65. Harvis, T. A. J., Reuben, B. G., Cox, D. J., Vaid, A. K. and Carvell, J. 1988. The cross flow filtration of an unstable beta lactam antibiotic fermentation broth. J. Chem. Technol. Biotechnol. 42:19-30.
66. Holst, O., Kaul, R., Larsson, M. and Mattiasson, B. 1987. Integration of bioconversions and downstream processing: some model studies. Annal. N.Y. Acad. Sci. 506:468-477.
67. Payne, G. F., Payne, N. N., Shuler, M. L. and Asada, M. 1988. In situ adsorption for enhanced alkaloid production by Catharanthus roseus. Biotechnol. Lett. 10:187-192.
68. Robins, R. J., Parr, A. J. and Rhodes, J. C. 1988. The use of continuous product removal to influence the distribution and net production of alkaloids by cell cultures. Biochem. Soc. Trans. 16:67-71.
69. Janssens, L., De Footer, H. L., Schamp, N. M. and Vandamme, E. J. 1992. Production of flavours by microorganisms. Process Biochem. 27:192-215.
70. Vandamme, E. J. 1992. Production of vitamins, coenzymes and related biochemicals by biotechnological processes. J. Chem. Tech. Biotechnol. 53:313-327.
71. Belin, J. M., Bensoussan, M. and Serrano-Carreon, L. 1992. Microbial biosynthesis for the production of food flavours. Trends in Food Science and Technology 3:11-14.
72. Schindler, J. 1982. Terpenoids by microbial fermentation. Ind. Eng. Chem. Prod. Res. Dev. 21:537-539.
73. Charlwood, B. V., Charlwood, K. A. and Brown, J. T. 1987. The effect of product removal on the accumulation of monoterpenes in pelargonium cultures. Proc. 4th European Congress on Biotechnology 2:444.
74. Maume, K. A. and Cheetham, P. S. J. 1991. The production of γ-decalactone by fermentation of castor oil. Biocatalysis 5:79-97.
75. de Wulf, O. and Thomart, P. 1989. Bioconversion of vanillin to vanillyl alcohol in a two phase reactor. App. Biochem. Biotechnol. 20/21:165-180.
76. Evans, P. J. and Wang, H. Y. 1984. Pigment production from immobilized Monascus sp. utilising polymeric resin adsorption. Appl. Environ. Microbiol. 47:1323-1326.
77. Robins, R. J. and Rhodes, M. J. C. 1986. The stimulation of anthraquinone production by Cinchona ledgeriana cultures with polymeric adsorbents. Appl. Microbiol. Biotechnol. 24:35-41.
78. Andersson, E., Johansson, A. C. and Hahn-Hagerdal, B. 1985. α-Amylase production in aqueous two phase systems with Bacillus subtilis. Enzyme Microb. Technol. 7:333-338.
79. Park, K. M. and Wang, N. S. 1991. Alpha amylase fermentation with Bacillus amyloliquefaciens in aqueous two phase system. Biotechnol. Prog. 7:439-444.
80. Persson, I., Tjerneld, F. and Hahn-Hagerdal, B. 1984. Semicontinuous cellulase production in an aqueous two-phase system with Trichoderma reesei Rutgers C30. Enzyme Microb. Technol. 6:415-418.
81. Hu, W. S., Scholz, M. T., Favre, E. and Seamens, T. C. 1991. A new look at animal cell bioreactor development, p. 370-378. In: Production of Biologicals from Animal Cells in Culture. Spier, R., Griffiths, J. B. and Meignier, B. (Eds.). Butterworth, Oxford.
82. Propst, C. L., Von Wedel, R. J. and Lubiniecki, A. S. 1989. Using mammalian cells to produce products, p. 221-276. In: Fermentation Process Development of Industrial Organisms. Neway, J. O. (Ed.). Marcel Dekker, N.Y.
83. Ehnstrom, L., Frisenfelt, J. and Danielsson, M. 1991. The biostil process, p. 303-321. In: Extractive Bioconversions, Mattiasson, B. and Holst, O. (Eds.). Marcel Dekker, N.Y.
84. Woodley, J. M. and Lilly, M. D. 1992. Process engineering of two-liquid phase biocatalysist, p. 147-154. In: Biocatalysis in Non-conventional Media. Tramper, J., Vermue, M. H., Beeftink, H. H. and von Stockar, U. (Eds.). Elsevier, Amsterdam.
85. Harrop, A. J., Woodley, J. M. and Lilly, M. D. 1992. Production of naphtha- lene-m-glycol by Pseudomonas putida in the presence of organic solvents. Enzyme Microb. Technol. 14:725-730.
86. Bruce, L. J. and Daugulis, A. J. 1991. Solvent selection strategies for extractive biocatalysis. Biotechnol. Prog. 7:116-124.
87. Honda, H., Mano, T., Taya, M., Shimizu, K., Matsubara, M. and Kobayashi, T. 1987. A general framework for the assessment of extractive fermentations. Chem. Eng. Sci. 42:493-498.
88. Daugulis, A. J., Axford, D. B. and McLellan, P. J. 1991. The economics of ethanol production by extractive fermentation. Canad. J. Chem. Eng. 69:488-497.
89. Roffler, S., Blanch, H. W. and Wilke, C. R. 1987. Extractive fermentation of acetone and butanol: process design and economic evaluation. Biotechnol. Prog. 3:131-140.
90. Woodley, J. M. and Lilly, M. D. 1990. Extractive biocatalysis: the use of two- liquid phase biocatalytic reactors to assist product recovery. Chem. Eng. Sci. 45:2391-2396.
91. Eckert, F. and Schugerl, K. 1987. Continuous acetone butanol fermentation with direct product removal. Chem. Eng. Tech. 59:958-959.
92. Hustedt, H., Menge, U. and Kula, M. R. 1985. Protein recovery using two phase systems. Trends in Biotechnol. 3:139-144.
93. Mattiasson, B. and Ling, T. G. I. 1987. Extraction in aqueous two-phase systems for biotechnology, p. 270-292. In: Separations for Biotechnology. Verrall, M. S. and Hudson, M. J. (Eds.). Ellis Horwood, Chichester.
94. Belfort, G. 1987. Membrane separation technology: An overview, p. 239-297. In: Advanced biochemical engineering. Bungay, H. R. and Belfort, G. (Eds.). Wiley, N.Y.
95. Thy a, M., Ishic, S. and Kobayashi, T. 1985. Monitoring and control for extractive fermentation of Clostridium acetobutylicum. J. Ferment. Technol. 63:181-187.
96. Kita, A., Tone, H., Ishikura, T. and Ozaki, A. 1968. Microbiol production of salicylic acid from naphthalene. II. Product inhibitory kinetics and effects of product removal on the fermentation. J. Ferment. Technol. 46:442-451.
97. Groot, W. J., van der Lans, R. G. J. M. and Luyben, K. Ch. A. M. 1989. Batch and continuous butanol fermentations with free cells: integration with product recovery by gas stripping. App. Microbiol. Biotechnol. 32:305-308.
98. Drawert, F. and Barton, H. 1978. Biosynthesis of flavour compounds by microorganisms. III. Production of monoterpenes by the yeast Kluyveromyces lactis. J. Agric. Food Chem. 26:765-766.
99. Hock, R., Benda, I. and Schreier, P. 1984. Formation of terpenes by yeast during alcoholic fermentation. Z. Lebens. Unter. Fors. 179:450-452.
100. Jourdain, N., Goli, T., Jallageas, J. C., Crouzet, C., Ghommidh, Ch., Navarro, J. M. and Crouzet, J. 1985. Aroma components production by immobilized cells, p. 427-441. In: Topics in Bioflavor Research. Berger, R. G., Nitz, S. and Schreier, P. (Eds.). Eichom, Marzling, F. R. G.
101. Georgiou, G., Lin, S. C. and Sharma, M. M. 1992. Surface-active compounds from microorganisms. Bio/Technology 10:60-65.
102. Arnold, F. H. 1991. Metal affinity separations: a new dimension in protein processing. Bio/Technology 9:151-156.
103. Szlag, D. C., Giuliano, K. A. and Snyder, S. M., 1990. A low cost aqueous two phase system for affinity extraction. ACS Symp. Ser. 419:71-86.
104. Dall-Bauman, L., and Ivory, C. F. 1990. Protein separation via affinity- mediated membrane transport. ACS Symp. Ser. 419:188-211.
105. Whitesides, G. 1983. Magnetic separation in biotechnology. Trends Biotechnol. 1:144-148.
106. Ekberg, B. and Mosbach, K. 1989. Molecular imprinting: a technique for producing specific separation materials. Trends Biotechnol. 7:92-96.
107. Yarmush, M. L., Antonsen, K. P., Sundaram, S. and Yarmush, D. M. 1992. Immunoadsorption: Strategies for antigen elution and production of reusable adsorbents. Biotechnol. Prog. 8:168-178.