Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat

Journal of Toxicological Sciences

Volumn 30, Issue 1, 2005, Pages 1-6

  Ichihara, Toshio ^a,c   Miyashita, Kayoko ^a,c   Kawabe, Mayumi ^a   Imaida, Katsumi ^b   Asamoto, Makoto ^c   Ogiso, Tadashi ^c   Tamano, Seiko ^a   Hirose, Masao ^d   Shirai, Tomoyuki ^c  

^a Daiyukai Research Institute for Medical Science   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Amitrole; Harman; Hepatocarcinogenesis; NaNO2; Norharman

Indexed keywords

AMINE; AMITROLE; BETA CARBOLINE; GLUTATHIONE TRANSFERASE; HARMAN; NITRO DERIVATIVE; SODIUM NITRITE;

ARTICLE; BIOASSAY; BODY WEIGHT; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER CARCINOGENESIS; MALE; NONHUMAN; RAT;

EID: 15744375542     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.30.1     Document Type: Article

References (32)

1. Fisher, R.A. (1955): Statistical methods and scientific induction. J. R. Stat. Soc [B], 17, 69-78.
2. Gad, S.C. and Weil, C.S. (1982): Statistics for toxicologists. In Principles and Methods of Toxicology (A. Wallace Hayes, ed.), pp.273-320, Raven Press, New York.
3. Gart, J.J., Chu, K.C. and Tarone, R.E. (1979): Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J. Natl. Cancer. Inst., 62, 957-974.
4. Gross, G. A. (1990): Simple methods for quantifying mutagenic heterocyclic aromatic amines in food products. Carcinogenesis, 11, 1597-1603.
5. Hagiwara, A., Arai, M., Hirose, M., Nakanowatari, J., Tsuda, H. and Ito, N. (1980): Chronic effects of norharman in rats treated with aniline. Toxicol. Lett., 6, 71-75.
6. Hagiwara, A., Tanaka, H., Kurata, Y., Kato, T., Tsuda, H. and Ito, N. (1990): Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman. J. Toxicol. Environ. Health., 29, 211-218.
7. Hagiwara, A., Sano, M., Asakawa, E., Tanaka, H., Hasegawa, R. and Ito, N. (1992): Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N- hydroxyethylnitrosamine. Jpn. J. Cancer Res., 83, 949-954.
8. International Agency for Research on Cancer (IARC)(2001): IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man, Vol. 79, pp. 381, Lyon, France.
9. Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T., Masui, T., Imaida, K., Fukushima, S. and Asamoto, M. (1988): Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats - an approach for a new medium-term bioassay system. Carcinogenesis, 9, 387-394.
10. Ito, N., Tamano, S. and Shirai, T. (2003): A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci., 94, 3-8.
11. Kawanishi, T., Ohno, Y., Takahashi, A., Ishiwata, H., Tanimura, A., Kasuya, Y. and Omori, Y. (1981): Studies on nitrosamine formation by the interaction between drugs and nitrite. I. Measurement of the amount of nitrosamine formed in rat and guinea pig stomachs. J. Toxicol. Sci., 6, 261-270.
12. Kuenzing, W., Chau, J., Norkus, E., Holowaschenko, H., Newmark, H., Mergens, W. and Conney, A.H. (1984): Caffeic and ferulic acid as blockers of nitrosamine formation. Carcinogenesis, 5, 309-313.
13. Lijinsky, W. and Greenblatt, M. (1972): Carcinogen dimethylnitrosamine produced in vivo from nitrite and aminopyrine. Nat. New. Biol., 236, 177-178.
14. Lijinsky, W., Taylor, H.W., Snyder, C. and Nettesheim, P. (1973): Malignant tumours of liver and lung in rats fed aminopyrine or heptamethyleneimine together with nitrite. Nature, 244, 176-178.
15. Lijinsky, W. (1987): Structure-activity relations in carcinogenesis by N-nitroso compounds. Cancer Metastasis Rev., 6, 301-356.
16. Mirvish, S.S. (1975): Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence. Toxicol. Appl. Pharmacol., 31, 325-351.
17. Nagao, M., Yahagi, T., Kawachi, T., Sugimura, T., Kosuge, T., Tsuji, K., Wakabayashi, K., Mizusaki, S. and Matsumoto, T. (1977): Comutagenic action of norharman and harman. Proc. Jpn. Acad., 53, 95-98.
18. Ogiso, T., Tatematsu, M., Tamano, S., Tsuda, H. and Ito, N. (1985): Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay. Toxicol. Pathol., 13, 257-265.
19. Ogiso, T., Tatematsu, M., Tamano, S., Hasegawa, R. and Ito, N. (1990): Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis, 11, 561-566.
20. Pitot, H.C.III and Dragan, Y.P.(2001): Chemical carcinogenesis. Casarett & Doull's Toxicology, (Curtis D. Klaassen, ed.), McGraw Hill Medical Publishing Division, 241-319.
21. Poindexter, E.H.Jr. and Carpenter, R.D. (1962): The isolation of harman and norharman from tobacco and cigarette smoke. Phytochemistry, 1, 215-221.
22. Scheunig, G., Horn, K.H. and Mehnert, W.H. (1979): Induction of tumors in Wistar rats after oral application of aminopyrine and nitrite. Arch. Geschwulstforsch., 49, 220-228.
23. Shirai, T., Hirose, M. and Ito, N. (1999): Medium-term bioassays in rats for rapid detection of the carcinogenic potential of chemicals. IARC Scientific Publ, 146, 251-272.
24. Steinhoff, D., Weber, H., Mohr, U. and Boehme, K. (1983): Evaluation of amitrole (Aminotriazole) for potential carcinogenicity in orally dosed rats, mice, and golden hamsters. Toxicol. Appl. Pharmacol., 69, 161-169.
25. Takase, S. and Murakami, H. (1966): Studies on the fluorescence of sake. I. Fluorescence spectrum of sake and identification of harman. Agric. Biol. Chem., 30, 869-876.
26. Takeuchi, T., Ogawa, K., Iimura, H., Suda, H., Ukita, K., Nagatsu, T., Kato, M., Umezawa, H. and Tanabe, O. (1973): Monoamine oxidase inhibitors isolated from fermented broths. J. Antibiot., 26, 162-167.
27. Tatematsu, M., Mera, Y., Inoue, T., Satoh, K., Sato, K. and Ito, N. (1988): Stable phenotypic expression of glutathione S-transferase placental type and unstable phenotypic expression of γ-glutamyltransferase in rat liver preneoplastic and neoplastic lesions. Carcinogenesis, 9, 215-220.
28. Totsuka, Y., Hada, N., Matsumoto, K., Kawahara, N., Murakami, Y., Yokoyama, Y., Sugimura, T. and Wakabayashi, K. (1998): Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline. Carcinogenesis, 19, 1995-2000.
29. Totsuka, Y., Takamura-Enya, T., Nishigaki, R., Sugimura, T. and Wakabayashi, K. (2004): Mutagens formed from beta-carbolines with aromatic amines. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 802, 135-141.
30. Umezawa, K., Shirai, A., Matsushima, T. and Sugimura, T. (1978): Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. Proc. Natl. Acad. Sci. USA, 75, 928-930.
31. Wynford-Thomas, D., Stringer, B.M. and Williams, E.D. (1982): Circadian rhythm of mitotic activity in normal and hyperplastic rat thyroid. Acta Endocrinol., 100, 46-50.
32. Yada, H., Hirose, M., Tamano, S., Kawabe, M., Sano, M., Takahashi, S., Futakuchi, M., Miki, T. and Shirai, T. (2002): Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model. Jpn. J. Cancer Res., 93, 1299-1307.