Inhibition of cyclin D1 expression and induction of apoptosis by inostamycin in small cell lung carcinoma cells

Japanese Journal of Cancer Research

Volumn 89, Issue 3, 1998, Pages 315-322

  Imoto, Masaya ^a   Tanabe, Keiko ^a   Simizu, Siro ^a   Tashiro, Etsu ^a   Takada, Minoru ^b   Umezawa, Kazuo ^a  

^a KEIO UNIVERSITY   (Japan)

^b Department of Cardiology   (Japan)

Author keywords

Caspase 3; Cyclin D1; Inostomycin; p27(KIP1)

Indexed keywords

CYCLIN D1; DNA FRAGMENT; INOSTAMYCIN; PROTEIN P21; PROTEIN P27;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE; CELL CYCLE G1 PHASE; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 15644372283     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1998.tb00564.x     Document Type: Article

References (40)

1. Hunter, T. and Pines, J. Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell, 79, 573-582 (1994).
2. Lees, E. Cyclin dependent kinase regulation. Curr. Opin. Cell Biol., 7, 773-780 (1995).
3. Kamb, A. Cell-cycle regulators and cancer. Trends Genet., 11, 136-140 (1995).
4. Sheaff, R. J. and Robert, J. M. Lessons in p16 from phylum falconium. Curr. Biol., 5, 28-31 (1995).
5. Hengartner, M. O. and Horvitz, H. R. Programmed cell death in Caenorhabditis elegans. Curr. Opin. Genet. Dev., 4, 581-586 (1994).
6. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. and Horvitz, H. R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell, 75, 641-652 (1993).
7. Vaux, D. L. and Strasser, A. The molecular biology of apoptosis. Proc. Natl. Acad. Sci. USA, 93, 2239-2244 (1996).
8. Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong, W. W. and Yuan, J. Human ICE/CED-3 protease nomenclature. Cell, 87, 171 (1996).
9. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T.-T., Yu, V. L. and Miller, D. K. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature, 376, 37-43 (1995).
10. Hengartner, M. O. and Horvitz, H. R. C. elegans cell-survival gene ced-9 encodes a functional homolog of the mammalian protooncogene bcl-2. Cell, 76, 665-676 (1994).
11. Reed, J. C. Bcl-2 and regulation of programmed cell death. J. Cell Biol., 124, 1-6 (1994).
12. Oltvai, Z. N. and Korsmeyer, S. J. Checkpoints of dueling dimers foil death wishes. Cell, 79, 189-192 (1994).
13. Boise, L. H., Gottschalk, A. R., Quintans, J. and Thompson, C. B. Cloning and expression of vertebrate apoptosis gene bcl-X and use of gene or BCL-X protein in diagnosis and therapy. Curr. Top. Microbiol. Immunol., 200, 107-121 (1995).
14. Lee, S., Christakos, S. and Small, M. B. Apoptosis and signal transduction: clues to a molecular mechanism. Curr. Opin. Cell Biol., 5, 286-291 (1993).
15. Imoto, M., Umezawa, K., Takahashi, Y., Naganawa, H., Iitaka, Y., Nakamura, H., Koizumi, Y., Sasaki, Y., Hamada, M., Sawa, T. and Takeuchi, T. Isolation and structure determination of inostamycin, a novel inhibitor of phosphatidylinositol turnover. J. Nat. Prod., 53, 825-829 (1990).
16. Imoto, M., Taniguchi, Y. and Umezawa, K. Inhibition of CDP-DG: inositol transferase by inostamycin. J. Biochem., 112, 299-302 (1992).
17. Imoto, M., Morii, T., Deguchi, A. and Umezawa, K. Involvement of phosphatidylinositol synthesis in the regulation of S phase induction. Exp. Cell Res., 215, 228-233 (1994).
18. Deguchi, A., Imoto, M. and Umezawa, K. Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor. J. Biochem., 120, 1118-1122 (1996).
19. Fernandes-Alnemri, T., Armstrong, R. C., Krebs, J., Srinivasula, S. M., Wang, L., Bullrich, F., Fritz, L. C., Trapani, J. A., Tomaselli, K. J., Litwack, G. and Alnemri, E. S. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl. Acad. Sci. USA, 93, 7464-7469 (1996).
20. Helin, K., Lees, J. A., Vidai, M., Dyson, N., Harlow, E. and Fattaey, A. A. cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell, 70, 337-350 (1992).
21. Krek,W., Ewen, M. E., Shirodkar, S., Arany, Z., Kaelin Jr., W. G. and Livingston, D. M. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell, 78, 161-172 (1994).
22. Baldin, V., Lukas, J., Marcote, M. J., Pagano, M. and Draetta, G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev., 7, 812-821 (1993).
23. Quelle, D. E., Ashmun, R. A., Shurtleff, S. A., Kato, J., Bar-Sagi, D., Roussel, M. F. and Sherr, C. J. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev., 7, 1559-1571 (1993).
24. Lukas, J., Jaduyel, D., Bartkova, J., Nacheva, E., Dyer, M. J., Strauss, M. and Bartek, J. BCL-1/cyclin D1 oncoprotein oscillates and subverts the G1 phase control in B-cell neoplasms carrying the t(11;14) translocation. Oncogene, 9, 2159-2167 (1994).
25. Ohtani, K., DeGregori, J. and Nevins, J. R. Regulation of the cyclin E gene by transcriptional factor E2F1. Proc. Natl. Acad. Sci. USA, 92, 12146-12510 (1995).
26. Botz, J., Zerfass-Thome, K., Spitkovsky, D., Delius, H., Vogt, B., Eilers, M., Hatzigeorgiou, A. and Jansen-Durr, P. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol., 16, 3401-3409 (1996).
27. Polyak, K., Lee, M.-H., Erdjument-Bromage, H., Tempst, P. and Massague, J. Cloning of p27KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell, 78, 59-66 (1994).
28. Toyoshima, H. and Hunter, T. p27, a novel inhibitor of G1 eyclin-edk protein kinase activity, is related to p21. Cell, 78, 67-74 (1994).
29. Reynisdottir, I., Polyak, K., Iavarone, A. and Massague, J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev., 9, 1831-1845 (1995).
30. EI-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, E., Kinzler, K. W. and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825 (1993).
31. Takahashi, T., Nau, M. M., Chiba, I., Birrer, M. J., Rosenberg, R. K., Vinocour, M., Levitt, M., Pass, H., Gazdar, A. F. and Minna, J. D. p53: a frequent target for genetic abnormalities in lung cancer. Science, 246, 491-494 (1989).
32. Sameshima, Y., Matsuno, Y., Hirohashi, S., Shimosato, Y., Mizoguchi, H., Sugimura, T., Terada, M. and Yokota, J. Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma. Oncogene, 7, 451-457 (1992).
33. WAF1/CIP1 mediated by STAT1. Science, 272, 719-722 (1996).
34. Pagano, M., Tam, S.W., Theodoras, A. M., Beer-Romero, P., Sal, G. D., Chau, V., Yew, P. R., Draetta, G. F. and Rolfe, M. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science, 269, 682-685 (1995).
35. Kuniyasu, H., Yasui, W., Kitahara, K., Naka, K., Yokozaki, H., Akama, Y., Hamamoto, T., Tahara, H. and Tahara, E. Growth inhibitory effect of interferon-β is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1 in a human gastric carcinoma cell line. Cell Growth Differ., 8, 47-52 (1997).
36. Kwon, T. K., Buchholz, M. A., Chrest, F. J. and Nordin, A. A. Staurosporine-induced G1 arrest is associated with the induction and accumulation of cyclin-dependent kinase inhibitors. Cell Growth Differ., 7, 1305-1313 (1996).
37. Shibata, Y., Nishimura, S., Okuyama, A. and Nakamura, T. p53-independent induction of apoptosis by cyclin-dependent kinase inhibition. Cell Growth Differ., 7, 887-891 (1996).
38. Dou, Q. P., An, B. and Will, P. L. Induction of u retino-blastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis. Proc. Natl. Acad. Sci. USA, 92, 9019-9023 (1995).
39. Chresta, C. M., Masters, J. R. W. and Hickman, J. A. Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Cancer Res., 56, 1834-1841 (1996).
40. Enari, M., Talanian, R. V., Wong, W. W. and Nagata, S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature, 380, 723-726 (1996).