Telomerase activity might persist in the human thymus throughout life

Journal of Clinical Pathology - Molecular Pathology

Volumn 51, Issue 3, 1998, Pages 170-173

  Brousset, P ^a   Al Saati, T ^a   Zenou, R C ^a   Delsol, G ^a  

^a CHU PURPAN   (France)

Author keywords

Elderly; Human; Telomerase; Thymus

Indexed keywords

TELOMERASE;

ADULT; AGED; AGING; ARTICLE; B LYMPHOCYTE; CHILD; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYMPHOMA CELL; NEWBORN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS;

EID: 15644369244     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.51.3.170     Document Type: Article

References (19)

1. Morin GB. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 1989;59:521-9.
2. Blackburn EH. Structure and function of telomeres. Nature 1991;350:569-73.
3. Rhyu M. Telomeres, telomerase, and immortality. J Natl Cancer Inst 1995;87:884-94.
4. Zakian VA. Telomeres: beginning to understand the end. Science 1995;270:1601-2.
5. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-14.
6. Piatyszek MA, Kim NW, Weinrich SL, et al. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol. Methods in Cell Science 1995;17:1-15.
7. Counter CM, Gupta J, Harley CB, et al. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 1995;85:2315-20.
8. Broccoli D, Young JW, De Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 1995;92:9082-6.
9. Hiyama K, Hirai Y, Kyoizumi S, et al. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 1995;155:3711-15.
10. Norrback KF, Dahlenborg K, Carlsson R, et al. Telomerase activation in normal B lymphocytes and non Hodgkin's lymphomas. Blood 1996;88:222-9.
11. Brousset P, Al Saati T, Chaouche N, et al. Telomerase activity in reactive and neoplastic lymphoid tissues: infrequent detection of activity in Hodgkin's disease. Blood 1997;89: 26-31.
12. Sprent J, Webb SR. Intrathymic and extrathymic clonal deletion of T cells. Curr Opin Immunol 1995;7:196-205.
13. Linette GP, Grusby MJ, Hedrick SM, et al. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points Immunity 1994;1:197-205.
14. Weng NP, Levine BL, June CH, et al. Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 1996;183:2471-9.
15. Monteiro J, Batliwalla F, Ostrer H, et al. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J Immunol 1996;156:3587-90.
16. Shi SR, Key ME, Kalra KL. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991;39:741-8.
17. Al Saati T, Tkaczuk J, Krissansen G, et al. A novel antigen detected by the CBF78 antibody further distinguishes anaplastic large cell lymphoma from Hodgkin's disease. Blood 1995;86:2741-6.
18. Mocchegiani E, Fabris N. Age-related thymus involution: zinc reverses in vitro the thymulin secretion defect. Int J Immunopharmacol 1995;17:745-9.
19. Mocchegiani E, Santarelli L, Muzzioli M, et al. Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice. Int J Immunopharmacol 1995;17:703-18.