The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family

European Journal of Immunology

Volumn 28, Issue 12, 1998, Pages 4071-4083

  McKay, Paul F ^a   Imami, Nesrina ^a   Johns, Michael ^a   Taylor Fishwick, David A ^b   Sedibane, Lucas M ^a   Totty, Nicholas F ^c   Hsuan, J Justin ^c,d   Palmer, Donald B ^a   George, Andrew J T ^a   Foxwell, Brian M J ^b   Ritter, Mary A ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

B cell; IL 4; Macrophage mannose receptor; Thymic microenvironment; Thymus

Indexed keywords

COMPLEMENTARY DNA; FIBRONECTIN; GLYCOPROTEIN; INTERLEUKIN 4 RECEPTOR; MANNOSE RECEPTOR; MEMBRANE PROTEIN; PROTEIN KINASE; TYROSINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOLECULAR CLONING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 15644365327     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199812)28:12<4071::AID-IMMU4071>3.0.CO;2-O     Document Type: Article

References (38)

1. De Maagd, R. A., MacKenzie, W. A., Schuurman, H.-J., Ritter, M. A., Price, K. M., Broekhuizen, R. and Kater, L., The human thymus microenvironment: heterogeneity detected by monoclonal anti-epithelial cell antibodies. Immunology 1985. 54: 745-754.
2. Larché, M., Lamb, J. R. and Ritter, M. A., A novel T lymphocyte molecule that may function in the induction of self-tolerance and MHC-restriction within the human thymic microenvironment. Immunology 1988. 64: 101-105.
3. Mat, I. B., Moors, N., Melcher, D., Foxwell, B. M. J. and Ritter, M. A., Comparison of MR6-Ag/IL-4 receptor complex and c-erB-2 antigen expression in breast tumours. In Lemoine, N. R. and Epenetos, A. A. (Eds.) Mutant Oncogenes, Targets for Therapy. Chapman & Hall, London 1992, pp 53-64.
4. Al-Tubuly, A. A., Spijker, R., Pignatelli, M., Kirkland, S. C. and Ritter, M. A., Inhibition of growth and enhancement of differentiation of colorectal carcinoma cell lines by mAb MR6 and IL-4. Int. J. Cancer 1997. 71: 605-611.
5. von Gaudecker, B., Larché, M., Schuurman, H.-J. and Ritter, M. A., Analysis of the fine distribution of thymic epithelial microenvironmental molecules by immunoelectron microscopy. Thymus 1989. 13: 187-194.
6. von Gaudecker, B., Kendall, M. D. and Ritter, M. A., Immuno-electron microscopy of the thymic microenvironment. Microsc. Res. Tech. 1997. 38: 1-13.
7. Larché, M., Lamb, J. R., O'Hehir, R. E., Imami-Shita, N., Zanders, E. and Ritter, M. A., Functional evidence for a monoclonal antibody that binds to the human interleukin-4 receptor. Immunology 1988. 65: 617-622.
8. Sivolapenko, G. B., Imami, N., Larché, M., Epenetos, A. A. and Ritter, M. A., Enhanced in vivo immunogenicity induced by an antibody to the IL-4 receptor-associated gp200-MR6 molecule. Scand. J. Immunol. 1996. 44: 135-142.
9. Imami, N., Larché, M. and Ritter, M. A., Inhibition of alloreactivity by mAb MR6: differential effects on IL-2- and IL-4-producing human T cells. Int. Immunol. 1994. 6: 1575-1584.
10. Kaklamanis, L., Koukourakis, M. I., Leek, R., Giatromanolaki, A., Ritter, M. A., Whitehouse, R., Gatter, K. C. and Harris, A. L., Loss of expression of the IL-4R-associated gp200-MR6 molecule in human breast cancer. Br. J. Cancer 1996. 74: 1627-1631.
11. Al Tubuly, A. A., Luqmani, Y. A., Shousa, S., Melcher, D. and Ritter, M. A., Down-regulation of the IL-4-receptor associated gp200-MR6 molecule in highly malignant tumours and differential expression in benign hyperplasia of the breast. Br. J. Cancer 1996. 74: 1005-1011.
12. Defrance, T., Aubry, J. P., Rousset, F., Vanbervliet, B., Bonnefoy, J. Y., Arai, N., Takebe, Y., Yokota, T., Lee, F. and Arai, K., Human recombinant Interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes. J. Exp. Med. 1987. 1: 1459-1467.
13. Jeanin, P., Delneste, Y., Lecoanet-Henchoz, S., Gauchat, J. F., Ellis, J. and Bonnefoy, J. Y, CD86 (B7-2) on human B cells. A functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells. J. Biol. Chem. 1997. 272: 15613-15619.
14. Taylor, M. E., Conary, J. T., Lennartz, M. R., Stahl, P. D. and Drikamer, K., Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains. J. Biol. Chem. 1990. 265: 12156-12162.
15. Ancien, P., Lambeau, G., Mattei, M. G. and Lazdunski, M., The human 180 kDa receptor for secretory phospholipase A2. Molecular cloning, identification of a secreted soluble form, expression and chromosomal localization. J. Biol. Chem. 1995. 270: 8963-8970.
16. Jiang, W., Swiggard, W., Heufler, C., Peng, M., Mirza, A., Steinman, R. and Nussenzweig, M. C., The receptor DEC-205 expressed on dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 1995. 375: 151-155.
17. Wu, K., Yuan, J. and Lasky, L. A., Characterization of a novel member of the macrophage mannose receptor type C lectin family. J. Biol. Chem. 1996. 271: 21323-21330.
18. Inaba, K., Swiggard, W. J., Inaba, M., Meltzer,J., Mirza, A., Sasagawa, T., Nussenzweig, M. C. and Steinman, R. M., Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. I. Expression on dendritic cells and other subsets of mouse leukocytes. Cell Immunol. 1995. 163: 148-156.
19. Swiggard, W. J., Mirza, A., Nussenzweig, M. C. and Steinman, R. M., DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization, and N-terminal amino acid sequence. Cell Immunol. 1995. 165: 302-311.
20. Witmer-Pack, M. D., Swiggard, W. J., Mirza, A., Inaba, K. and Steinman, R. M., Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. II. Expression in situ in lymphoid and non-lymphoid tissues. Cell Immunol. 1995. 163: 157-162.
21. Russell, S. M., Keegan, A. D., Harada, N., Nakamura, Y., Noguchi, M., Leland, P., Friedman, M. C., Miyajima, A., Puri, R. K., Paul, W. E. and Leonard, W., Interleukin-2 receptor gamma chain: a functional com-ponent of the IL-4 receptor. Science 1993. 262: 1880-1883.
22. Murata, T., Noguchi, P. D. and Puri, R. K., Receptors for interleukin (IL)-4 do not associate with the common γ chain, and IL-4 induces the phosphorylation of Jak2 tyrosine kinase in human colon carcinoma cells. J. Biol. Chem. 1996. 270: 30829-30836.
23. Gauchat, J.-K., Schlagenhauf, E., Feng, N.-P., Moser, R., Yamage, M., Jeannin, P., Alouani, S., Elson, G., Notarangelo, L. D., Wells, T., Eugster, H.-P. and Bonnefoy, J.-Y., A novel 4-kb interleukin-13 receptor α mRNA expressed in human B, T and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. Eur. J. Immunol. 1997. 27: 971-978.
24. Matthews, D. J., Hibbert, L., Friedrich, K., Minty, A. and Callard, R. E., X-SCID B cell responses to interleukin-4 and interleukin-13 are mediated by a receptor complex that includes the interleukin-4 receptor alpha chain (p140) but not the gamma chain. Eur. J. Immunol. 1997. 27: 116-121.
25. Yoshimura, A., Ohkubo, T., Kiguchi, T., Jankins, N. A., Gilbert, D. J., Copeland, N. G., Hara, T. and Miyaijama, A., A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 1995. 14: 2816-2826.
26. Endo, T. A., Msuhara,M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., Miyazaki, T., Leonor, N., Taniguchi, T., Fujita, T., Kanakura, Y., Komiya, S. and Yoshimura, A., A new protein containing an SH2 domain that inhibits Jak kinases. Nature 1997. 387: 921-924.
27. Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkin, B. J., Gonda, T. J., Alexander, W. S., Matcalf, D., Nicola, N. A. and Hilton, D. J., A family of cytokine-inducible inhibitors of signalling. Nature 1997. 387: 917-921.
28. Ryan, J. J., McReynolds, L. J., Keegan, A., Wang, L.-H., Garfein, E., Rothman, P., Nelms, K. and Paul, W. E., Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Immunity 1996. 4: 123-132.
29. Qiu, Y., Lakshmeswari, R. and Kung, H.-J., Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells. Nature 1998. 393: 83-85.
30. Ancien, P., Lambeau, G. and Lazdunski, M., Multifunctional activity of the extracellular domain of the M-type (180 kDa) membrane receptor for secretory phospholipases A2. Biochemistry 1995. 34: 13146-13151.
31. Sallusto, F., Cella, M., Danieli, C. and Lanzavecchia, A., Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 1995. 182: 389-400.
32. Martinez-Pomares, L., Kosco-Vilbois, M., Darley, E, Tree, P., Herren, S., Bonnefoy, J. Y. and Gordon, S., Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centres. J. Exp. Med. 1996. 184: 1927-1937.
33. Tessier, C., Rossini, G. P., Pageaux, J. F., Cohen, H., Lagarde, M., Laugier, C. and Fayard, J. M., The level of pancreatic PLA2 receptors is closely associated with the proliferative state of rat uterine stromal cells. FEBS Lett. 1996. 390: 311-314.
34. Zvaritch, E., Lambeau, G. and Lazdunski, M., Endocytic properties of the M-type 180 kDa receptor for secretory phospholipases A2. J. Biol. Chem. 1996. 271: 250-257.
35. Taylor, M. E., Bezouska, K. and Drickamer, K., Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. J. Biol. Chem. 1992. 267: 1719-1726.
36. Taylor, M. E. and Drickamer, K., Structural requirements for high affinity binding of complex ligands by the macrophage mannose receptor. J. Biol. Chem. 1993. 268: 399-404.
37. Spurr, N. K., Durbin, H., Sheer, D., Parkar, M., Bobrow, L. and Bodmer, W. F. Characterisation and chromosomal assignment of a human cell surface antigen defined by the monoclonal antibody AUA1. Int. J. Cancer 1986. 38: 631-636.
38. Totty, N. F., Waterfield, M. D. and Hsuan, J. J., Accelerated high sensitivity microsequencing of proteins and peptides using a miniature reaction cartridge. Protein Sci. 1992. 1: 1215-1224.