The influence of dehydroepiandrosterone and 8-OH-DPAT on the caloric intake and hypothalamic neurotransmitters of lean and obese Zucker rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 288, Issue 4 57-4, 2005, Pages

  Porter, Johnny R ^a,c   Van Vrancken, Michael ^a   Corll, Connie ^a   Thompson, Hilary ^b   Svec, Frank ^a  

^a Obesity Research Program   (United States)

^b LSU EYE CENTER   (United States)

^c LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calorie intake; Dehydryoepiandrosterone; Monoamine; Obesity

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 HYDROXYINDOLEACETIC ACID; PRASTERONE; SEROTONIN; SEROTONIN 1A AGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; FEEDBACK SYSTEM; FEMALE; FOOD INTAKE; HYPOTHALAMUS; LEAN BODY WEIGHT; MALE; NEUROTRANSMISSION; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; RAT; RAT STRAIN; SATIETY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; DEHYDROEPIANDROSTERONE; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY INTAKE; FEMALE; HYPOTHALAMUS; MALE; NEUROTRANSMITTER AGENTS; OBESITY; PHENOTYPE; RATS; RATS, ZUCKER; SATIATION; SEROTONIN AGONISTS;

EID: 15544383013     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00290.2003     Document Type: Article

References (27)

1. Abadie JM, Wright B, Correa G, Browne ES, Porter JR, and Svec F. Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat. Diabetes 42: 662-669, 1993.
2. Bagdy G, Calogero AE, Aulakh CS, Szemeredi K, and Murphy DL. Long-term cortisol treatment impairs behavioral and neuroendocrine response to 5-HT1 agonists in the rat. Neuroendocrinology 50: 241-247, 1989.
3. Beaujean D, Do-Rego JL, Galas L, Mensah-Nyagan AG, Fredriksson R, Larhammar D, Fournier A, Luu-The V, Pelletier G, and Vaudry H. Neuropeptide Y inhibits the biosynthesis of sulfated neurosteroids in the hypothalamus through activation of Y1 receptors. Endocrinology 143: 1950-1963, 2002.
4. Edmonds BK and Edwards GL. Dorsomedial hindbrain participation in glucoprivic feeding response to 2 DG but not 2DG-induced hyperglycemia or activation of the HPA axis. Brain Res 801: 21-28, 1998.
5. 1A receptor activation in rats. Psychoneuroendocrinology 13: 471-478, 1988.
6. Haleem DJ. Repeated corticosterone treatment attenuates behavioural and neuroendocrine responses to 8-hydroxy-2-(di-n-propylamino) tetralin in rats. Life Sci 51: 225-230, 1992.
7. 1A receptors. Eur J Pharmacol 150: 361-366, 1988.
8. Meguid MM, Ramos EJ, Laviano A, Varma M, Sato T, Chen C, Qi Y, and Das UN. Tumor anorexia: effects of neuropeptide Y and monoamines in the paraventricular nucleus. Peptides 25: 261-266, 2004.
9. Miller CC, Holmes PV, and Edwards GL. Area postrema lesions elevate NPY levels and decrease anxiety-related behavior in rats. Physiol Behav 77: 135-140, 2002.
10. Murakami K, Nakagawa T, Shozu M, Uchide K, Koike K, and Inoue M. Changes with aging of steroidal levels in the cerebrospinal fluid of women. Maturitas 33: 71-80, 1999.
11. Nestler JE, Barlascini CO, Clore JN, and Blackard WG. Dehydroepiandrosterone reduces serum low-density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab 66: 57-61, 1988.
12. Pham J, Porter J, Svec D, Eiswirth C, and Svec F. The effect of dehydroepiandrosterone on Zucker rats selected for fat food preference. Physiol Behav 70: 431-441, 2000.
13. Porter JR, Abadie JM, Wright BE, Browne ES, and Svec F. The effect of discontinuing dehydroepiandrosterone supplementation on Zucker rat food intake and hypothalamic neurotransmitters. Int J Obes 19: 480-488, 1995.
14. Richards RJ, Porter JR, and Svec F. Long-term oral administration of dehydroepiandrosterone has different effects on energy intake of young lean and obese male Zucker rats compared with controls of similar metabolic body size. Diab Obes Metab 1: 233-239, 1999.
15. 1A) receptor agonist, 8-OH-DPAT, attenuates stress-induced anorexia in conjunction with the suppression of hypothalamic serotonin release in rats. Brain Res 887: 178-182, 2000.
16. Svec F and Porter JR. Influence of diet and dehydroepiandrosterone on hypothalamic monoamine neurotransmitters in Zucker rats. Nutr Neurosc 2, 337-345, 1999.
17. Svec F and Porter JR. DHEA: A Comprehensive Review, edited by Thijssen J. H. H. and Nieuwenhuyse H. Utrecht University, Utrecht, The Netherlands: Utrecht University and Utrecht, The Netherlands: International Health Foundation, 1999.
18. Svec F and Porter JR. Dehydroepiandrosterone: A nutritional supplement with actions in the central nervous system. Nutr Neurosci 1: 9-19, 1998.
19. Svec F and Porter JR. The actions of exogenous dehydroepiandrosterone in experimental animals and humans. Proc Soc Biol Med 218: 174-191, 1998.
20. Svec F and Porter JR. The effect of dehydroepiandrosterone (DHEA) on Zucker rat food selection and hypothalamic neurotransmitters. Psychoneuroendocrinology 22: S57-S62, 1997.
21. Svec F and Porter J. Effect of DHEA on macronutrient selection by Zucker rats. Physiol Behav 59, 721-727, 1996.
22. Svec F and Porter JR. Synergistic anorectic effect of dehydroepiandrosterone and fenfluramine on Zucker rat food intake and selection. Obes Res Prog Ann NY Acad Sci 774: 332-334, 1995.
23. Svec F, Richards RJ, and Porter JR. Investigating the debate: does DHEA alter food intake? Nutr Neurosci 1: 93-101, 1998.
24. Voigt JP, Kienzle F, Sohr R, Rex A, and Fink, R. Feeding and 8-OH-DPAT-related release of serotonin in the rat lateral hypothalamus. Pharmacol, Biochem Behav 65: 183-189, 2000.
25. White CL, Kashima K, Bray GA, and York DA. Effect of a serotonin 1-A agonist on food intake of Osborne-Mendel and S5B/P1 rats. Physiol Behav 68: 715-722, 2000.
26. Wright BE, Svec F, and Porter JR. Central effects of dehydroepiandrosterone in Zucker rats. Int J Obes 19: 887-892.
27. Zifa E and Fillion G. 5-Hydroxytryptamine receptors. Pharmacol. Rev 44: 401-458, 1992.