Successful use in lung transplantation of an immunosuppressive regimen aimed at reducing target blood levels of sirolimus and tacrolimus

Journal of Heart and Lung Transplantation

Volumn 24, Issue 4, 2005, Pages 421-425

  Villanueva, Jaime ^a   Boukhamseen, Ali ^b   Bhorade, Sangeeta M ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b DHAHRAN HEALTH CENTER   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; COTRIMOXAZOLE; FIBRIC ACID DERIVATIVE; GANCICLOVIR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ITRACONAZOLE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; STEROID; TACROLIMUS; TRIACYLGLYCEROL;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; BRONCHIOLITIS OBLITERANS; CLINICAL ARTICLE; DEMOGRAPHY; DISEASE EXACERBATION; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG TARGETING; DRUG USE; DRUG WITHDRAWAL; EXPERIENCE; FEMALE; FOLLOW UP; GENERAL CONDITION IMPROVEMENT; HUMAN; HYPERLIPIDEMIA; IMMUNOSUPPRESSIVE TREATMENT; INTERSTITIAL PNEUMONIA; LABORATORY; LEUKOPENIA; LIVER DISEASE; LIVER FAILURE; LUNG EMBOLISM; LUNG GRAFT REJECTION; LUNG HEMORRHAGE; LUNG TRANSPLANTATION; MALE; MEDICAL INFORMATION; POSTOPERATIVE COMPLICATION; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; PROTECTION; RASH; RECIPIENT; RETROSPECTIVE STUDY; SEPSIS; SIDE EFFECT; TRANSBRONCHIAL BIOPSY; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 15544382381     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2004.01.014     Document Type: Article

References (25)

1. Cooper J.D., Patterson G.A., Trulock E.P. Results of single and bilateral lung transplantation in 131 consecutive recipients. Washington University Lung Transplant Group. J Thorac Cardiovasc Surg. 107:1994;460-470
2. Husain A.N., Siddiqui M.T., Holmes E.W., et al. Analysis of risk factors for the development of bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 159:1999;829-833
3. Sundaresan S., Trulock E.P., Mohanakumar T., Cooper J.D., Patterson G.A. Prevalence and outcome of bronchiolitis obliterans syndrome after lung transplantation. Washington University Lung Transplant Group. Ann Thorac Surg. 60:1995;1341-1346
4. Horning N.R., Lynch J.P., Sundaresan S.R., Patterson G.A., Trulock E.P. Tacrolimus therapy for persistent or recurrent acute rejection after lung transplantation. J Heart Lung Transplant. 17:1998;761-767
5. Kesten S., Chaparro C., Scavuzzo M., Gutierrez C. Tacrolimus as rescue therapy for bronchiolitis obliterans syndrome. J Heart Lung Transplant. 16:1997;905-912
6. Cahill B.C., Sommerville K.T., Cromptom J.A., et al. Early experience with sirolimus in lung transplant recipients with chronic allograft rejection. J Heart Lung Transplant. 22:2003;169-176
7. Keenan R.J., Konoshi H., Kawai A., et al. Clinical trial of tacrolimus versus cyclosporine in lung transplantation. Ann Thorac Surg. 60:1995;580-585
8. Groth C.G., Backman L., Morales J.M., et al. Sirolimus (rapamycin)-based therapy in human renal transplantation Similar efficacy and different toxicity compared with cyclosporine. sirolimus european renal transplant study group. Transplantation. 67:1999;1036-1042
9. Watson C.J., Friend P.J., Jamieson N.V., et al. Sirolimus A potent new immunosuppressant for liver transplantation. Transplantation. 67:1999;505-509
10. Cao W., Mohacsi P., Shorthouse R., Pratt R., Morris R.E. Effects of rapamycin on growth factor-stimulated vascular smooth muscle cell DNA synthesis. Inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of rapamycin by FK506. Transplantation. 59:1995;390-395
11. Gregory C.R., Huang X., Pratt R.E., et al. Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement. Transplantation. 59:1995;655-661
12. Akselband Y., Harding M.W., Nelson P.A. Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts. Transplant Proc. 23:1991;2833-2836
13. Dunitz J., Bolman R.M., Park S., et al. Sirolimus based immunosuppression in lung transplant recipients. Transplantation. S103:1999;385
14. Groth C.G., Brattstrom C., Claesson K., Backman L. New trails in transplantation How to exploit the potential of sirolimus in clinical transplantation. Transplant Proc. 30:1998;4064-4065
15. Garrity E.R., Hertz M.I., Trulock E.P., Keenan R., Love R. Suggested guidelines for the use of tacrolimus in lung transplant recipients. J Heart Lung Transplant. 18:1999;175-176
16. Longoria J., Roberts R., Marboe C.C., Stouch B.C., Starnes V.A., Barr M.L. Sirolimus (rapamycin) potentiates cyclosporine in prevention of acute lung rejection. J Thorac Cardiovasc Surg. 117:1999;714-718
17. Estenne M., Maurer J.R., Boehler A., et al. Bronchiolitis obliterans syndrome 2001 An update of the diagnostic criteria. J Heart Lung Transplant. 21:2002;297-310
18. Gaston R.S. Potential utility of rapamycin and tacrolimus in long-term, low-toxicity regimens. Transplant Proc. 31:1999;17S-22S
19. Morris R.E., Huang X., Gregory C.R., et al. Studies in experimental models of chronic rejection Use of rapamycin (sirolimus) and isoxazole derivatives(leflunomide and its analogue) for the suppression of graft vascular disease and obliterative bronchiolitis. Transplant Proc. 27:1995;2068-2069
20. Reichenspurner H., Soni V., Nitschke M., et al. Obliterative airway disease after heterotopic tracheal xenotransplantation Pathogenesis and prevention using new immunosuppressive agents. Transplantation. 64:1997;373-383
21. Fahrni J.A., Berry G.J., Morris R.E., Rosen G.D. Rapamycin inhibits development of obliterative airway disease in a murine heterotopic airway transplant model. Transplantation. 63:1997;533-537
22. Kahan B.D. Sirolimus A new agent for clinical renal transplantation. Transplant Proc. 29:1997;48-50
23. Morelon E., Stern M., Kreis H. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. N Engl J Med. 343:2000;225-226
24. Singer S.J., Tiernan R., Sullivan E.J. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. N Engl J Med. 343:2000;1815-1816
25. McWilliams T.J., Bronwyn L.J., Rusell P.A., Milne D.G., Snell G.I. Interstitial pneumonitis associated with sirolimus A dilemma for lung transplantation. J Heart Lung Transplant. 22:2003;210-213