New simple tests for age-at-onset anticipation: Application to panic disorder

Genetic Epidemiology

Volumn 28, Issue 3, 2005, Pages 256-260

  Tsai, W Y ^a,c   Heiman, Gary A ^a   Hodge, Susan E ^a,b  

^a Department of Medicine   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c Department of Biostatistics   (United States)

Author keywords

Age at onset anticipation; Ascertainment bias; Panic disorder; Random effects model; Right truncation

Indexed keywords

ARTICLE; CHILD PARENT RELATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; ONSET AGE; PANIC; PERSONALITY TEST; WILCOXON SIGNED RANKS TEST;

AGE OF ONSET; HUMANS; MODELS, GENETIC; MODELS, STATISTICAL; NUCLEAR FAMILY; PANIC DISORDER; PARENTS; STATISTICS, NONPARAMETRIC;

EID: 15544368376     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/gepi.20057     Document Type: Article

References (9)

1. Fyer AJ, Weissman MM. 1999. Genetic linkage study of panic: Clinical methodology and description of pedigrees. Am J Med Genet (Neuropsychiatr Genet) 81:139-147.
2. Heiman GA, Hodge SE, Wickramaratne P, Hsu H. 1996. Age-at-interview bias in anticipation studies: computer simulations and an example with panic disorder. Psychiatr Genet 6:61-66.
3. Hodge SE, Wickramaratne P. 1995. Statistical pitfalls in detecting age-of-onset anticipation: The role of correlation in studying anticipation and detecting ascertainment bias. Psychiatr Genet 5:43-47.
4. Huang J, Vieland V. 1997. A new statistical test for age-of-onset anticipation: Application to bipolar disorder. Genet Epidemiol 14:1091-1096.
5. Huang J, Vieland V, Wang K. 2001. Nonparametric estimation of marginal distributions under bivariate truncation with application to testing for age-of-onset anticipation. Stat Sinica 11:1047-1068.
6. Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA, Haghighi F, de Jesus G, Rassnick H, Preud'homme-Rivelli X, Austin T, Cunjak J, Mick S, Fine LD, Woodley KA, Das K, Maier W, Adams PB, Freimer NB, Klein DF, Gilliam TC. 1998. Results of a genome-wide genetic screen for panic disorder. Am J Med Genet (Neuropsychiatr Genet) 81:139-147.
7. Rabinowitz D, Yang Q. 1999. Testing for age-at-onset anticipation with affected parent-child pairs. Biometrics 55:834-838.
8. Tsai WY. 1990. Testing the assumption of independence between truncated time and failure time. Biometrika 77:169-177.
9. Vieland V, Huang J. 1998. Statistical evaluation of age-at-onset anticipation: A new test and evaluation of its behavior in realistic applications. Am J Hum Genet 62:1212-1227.