Transcriptional control of the rhuIR-bhuRSTUV heme acquisition locus in Bordetella avium

Infection and Immunity

Volumn 73, Issue 3, 2005, Pages 1613-1624

  King, Natalie D ^a,b   Kirby, Amy E ^a,b   Connell, Terry D ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME; HEMIN; HEMOGLOBIN; HEMOPROTEIN; IRON COMPLEX; BACTERIAL PROTEIN; BHUR PROTEIN, BORDETELLA PERTUSSIS; CELL SURFACE RECEPTOR; IRON UPTAKE REGULATION PROTEIN, BACTERIA; IRON-UPTAKE REGULATION PROTEIN, BACTERIA; PRIMER DNA; REPRESSOR PROTEIN; RHUI PROTEIN, BORDETELLA AVIUM; SIGMA FACTOR;

ARTICLE; BACTERIAL GENE; BHUR GENE; BORDETELLA AVIUM; FUR GENE; GENE; GENE ACTIVATION; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE LOCUS; GENE REPRESSION; HOST; NONHUMAN; NUTRIENT; OPERON; PRIORITY JOURNAL; PROMOTER REGION; RHUI GENE; RHUR GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; VERTEBRATE; ANIMAL; DNA SEQUENCE; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM;

ANIMALS; BACTERIAL PROTEINS; BORDETELLA AVIUM; DNA PRIMERS; GENE EXPRESSION REGULATION, BACTERIAL; HEME; OPERON; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA; SIGMA FACTOR; TRANSCRIPTION, GENETIC;

EID: 15544365323     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.3.1613-1624.2005     Document Type: Article

References (30)

1. Angerer, A., S. Enz, M. Ochs, and V. Braun. 1995. Transcriptional regulation of ferric citrate transport in Escherichia coli K-12. Fecl belongs to a new subfamily of sigma 70-type factors that respond to extracytoplasmic stimuli. Mol. Microbiol. 18:163-174.
2. Beaumont, F. C., H. Y. Kang, T. J. Brickman, and S. K. Armstrong. 1998. Identification and characterization of alcR, a gene encoding an AraC-like regulator of alcaligin siderophore biosynthesis and transport in Bordetella pertussis and Bordetella bronchiseptica. J. Bacteriol. 180:862-870.
3. Braun, V., and H. Killmann. 1999. Bacterial solutions to the iron-supply problem. Trends Biochem. Sci. 24:104-109.
4. Chauhan, S., and M. R. O'Brian. 1997. Transcriptional regulation of delta-aminolevulinic acid dehydratase synthesis by oxygen in Bradyrhizobium japonicum and evidence for developmental control of the hemB gene. J. Bacteriol. 179:3706-3710.
5. Connell, T. D., A. Dickenson, A. J. Martone, K. T. Militello, M. J. Filiatraut, M. L. Hayman, and J. Pitula. 1998. Iron starvation of Bordetella avium stimulates expression of five outer membrane proteins and regulates a gene involved in acquiring iron from serum. Infect. Immun. 66:3597-3605.
6. Dean, C. R., S. Neshat, and K. Poole. 1996. PfeR, an enterobactin- responsive activator of ferric enterobactin receptor gene expression in Pseudomonas aeruginosa. J. Bacteriol. 178:5361-5369.
7. de Lorenzo, V., S. Wee, M. Herrero, and J. B. Neilands. 1987. Operator sequences of the aerobactin operon of plasmid ColV-K30 binding the ferric uptake regulation (fur) repressor. J. Bacteriol. 169:2624-2630.
8. Enz, S., V. Braun, and J. H. Crosa. 1995. Transcription of the region encoding the ferric dicitrate-transport system in Escherichia coli: similarity between promoters for fecA and for extracytoplasmic function sigma factors. Gene 163:13-18.
9. Enz, S., S. Mahren, U. H. Stroeher, and V. Braun. 2000. Surface signaling in ferric citrate transport gene induction: interaction of the FecA, FecR, and FecI regulatory proteins. J. Bacteriol. 182:637-646.
10. Escolar, L., J. Perez-Martin, and V. de Lorenzo. 1999. Opening the iron box: transcriptional metalloregulation by the Fur protein. J. Bacteriol. 181:6223-6229.
11. Gutierrez, C., J. Barondess, C. Manoil, and J. Beckwith. 1987. The Use of TnphoA to detect genes for cell envelope proteins subject to a common regulatory stimulus. Analysis of osmotically related genes in Escherichia coli. J. Mol. Biol. 19:289-297.
12. Hamza, I., Z. Qi, N. D. King, and M. R. O'Brian. 2000. Fur-independent regulation of iron metabolism by Irr in Bradyrhizobium japonicum. Microbiology 146:669-676.
13. Harle, C., I. Kim, A. Angerer, and V. Braun. 1995. Signal transfer through three compartments: transcription initiation of the Escherichia coli ferric citrate transport system from the cell surface. EMBO J. 14:1430-1438.
14. Heinrichs, D. E., and K. Poole. 1996. PchR, a regulator of ferripyochelin receptor gene (fptA) expression in Pseudomonas aeruginosa, functions both as an activator and as a repressor. J. Bacteriol. 178:2586-2592.
15. Keen, N. T., S. Tamaki, D. Kobayashi, and D. Trollinger. 1988. Improved broad-host-range plasmids for DNA cloning in gram-negative bacteria. Gene 70:191-197.
16. Kirby, A. E., N. D. King, and T. D. Connell. 2004. RhuR, an extracytoplasmic function sigma factor activator, is essential for heme-dependent expression of the outer membrane heme and hemoprotein receptor of Bordetella avium. Infect. Immun. 72:896-907.
17. Kirby, A. E., D. J. Metzger, E. R. Murphy, and T. D. Connell. 2001. Heme utilization in Bordetella avium is regulated by RhuI, a heme-responsive extracytoplasmic function sigma factor. Infect. Immun. 69:6951-6961.
18. Koster, M., W. van Klompenburg, W. Bitter, J. Leong, and P. Weisbeek. 1994. Role for the outer membrane ferric siderophore receptor PupB in signal transduction across the bacterial cell envelope. EMBO J. 13:2805-2813.
19. Litwin, C. M., and S. B. Calderwood. 1993. Role of iron in regulation of virulence genes. Clin. Microbiol. Rev. 6:137-149.
20. Litwin, C. M., and J. Quackenbush. 2001. Characterization of a Vibrio vulnificus LysR homologue, HupR, which regulates expression of the haem uptake outer membrane protein, HupA. Microb. Pathog. 31:295-307.
21. Miller, J. H. 1992. A short course in bacterial genetics. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
22. Murphy, E. R., R. E. Sacco, A. Dickenson, D. J. Metzger, Y. Hu, P. E. Orndorff, and T. D. Connell. 2002. BhuR, a virulence-associated outer membrane protein of Bordetella avium, is required for the acquisition of iron from heme and hemoproteins. Infect. Immun. 70:5390-5403.
23. Ochs, M., S. Veitinger, I. Kim, D. Welz, A. Angerer, and V. Braun. 1995. Regulation of citrate-dependent iron transport of Escherichia coli: fecR is required for transcription activation by FecI. Mol. Microbiol. 15:119-132.
24. Prentki, P., and H. M. Krisch. 1984. In vitro insertional mutagenesis with a selectable DNA fragment. Gene 29:303-313.
25. Schmitt, M. P. 1999. Identification of a two-component signal transduction system from Corynebacterium diphtheriae that activates gene expression in response to the presence of heme and hemoglobin. J. Bacteriol. 181:5330-5340.
26. Vanderpool, C. K., and S. K. Armstrong. 2001. The Bordetella bhu locus is required for heme iron utilization. J. Bacteriol. 183:4278-4287.
27. Vanderpool, C. K., and S. K. Armstrong. 2003. Heme-responsive transcriptional activation of Bordetella bhu genes. J. Bacteriol. 185:909-917.
28. Vanderpool, C. K., and S. K. Armstrong. 2004. Integration of environmental signals controls expression of Bordetella heme utilization genes. J. Bacteriol. 186:938-948.
29. Van Hove, B., H. Staudenmaier, and V. Braun. 1990. Novel two-component transmembrane transcription control: regulation of iron dicitrate transport in Escherichia coli K-12. J. Bacteriol. 172:6749-6758.
30. Weinberg, E. D. 1993. The development of awareness of iron-withholding defense. Perspect. Biol. Med. 36:215-221.