Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2

Journal of Biological Chemistry

Volumn 280, Issue 11, 2005, Pages 10572-10577

  Nobukuni, Yoshitaka ^a   Kohno, Kenji ^b   Miyagawa, Kiyoshi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOCHEMISTRY; BIOLOGICAL ORGANS; BIOSYNTHESIS; CHROMOSOMES; CLONING; TOXICITY; TUMORS;

BIOCHEMICAL FUNCTIONS; CELL PROLIFERATION; OVARIAN CANCERS; TUMORIGENESIS;

MUTAGENESIS;

DIPHTHAMIDE; DIPHTHERIA TOXIN; ELONGATION FACTOR 2; HISTIDINE DERIVATIVE; PSEUDOMONAS EXOTOXIN; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CHO CELL; CONTROLLED STUDY; GENE DISRUPTION; GENE IDENTIFICATION; GENE LIBRARY; MAMMAL CELL; MUTAGENESIS; NONHUMAN; OVCA1 GENE; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOSINE DIPHOSPHATE; ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CHO CELLS; COLORING AGENTS; CRICETINAE; DIPHTHERIA TOXIN; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, TUMOR SUPPRESSOR; GENETIC TECHNIQUES; HISTIDINE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PEPTIDE ELONGATION FACTOR 2; PHENOTYPE; PLASMIDS; POLYMERASE CHAIN REACTION; PROTEINS; RETROVIRIDAE; SEQUENCE HOMOLOGY, NUCLEIC ACID; TETRAZOLIUM SALTS; THIAZOLES; TOXINS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; MAMMALIA; PSEUDOMONAS; PSEUDOMONAS EXOTOXIN; STAPHYLOCOCCUS PHAGE 3A;

EID: 15444380476     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413017200     Document Type: Article

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