Androgens stimulate human vascular smooth muscle cell proteoglycan biosynthesis and increase lipoprotein binding

Endocrinology

Volumn 146, Issue 4, 2005, Pages 2085-2090

  Hashimura, Kazuhiko ^a   Sudhir, Krishnankutty ^a,c   Nigro, Julie ^a,b   Ling, Shanhong ^a   Williams, Maro R I ^a   Komesaroff, Paul A ^a   Little, Peter J ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANDROSTENEDIONE; ANTIANDROGEN; BIGLYCAN; CYSTEINE; DECORIN; FLUTAMIDE; GLYCOSAMINOGLYCAN; LOW DENSITY LIPOPROTEIN; METHIONINE; PROTEOGLYCAN; SULFATE; SULFUR 35; TESTOSTERONE;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; INTERNAL MAMMARY ARTERY; ISOTOPE LABELING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; VASCULAR SMOOTH MUSCLE;

ANDROGENS; ARTERIOSCLEROSIS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIPOPROTEINS, LDL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROTEOGLYCANS; RECEPTORS, ANDROGEN; SULFATES;

EID: 15444372892     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1242     Document Type: Article

References (39)

1. Gorodeski G, Utian W 1994 Epidemiology and risk factors of cardiovascular disease in postmenopausal women. In: Lobo R, ed. Treatment of the post-menopausal woman: basic and clinical aspects. New York: Raven Press; 199-221
2. Venneulen A, Verdonck L, Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672
3. Somjen D, Kohen F, Jaffe A, Amir-Zaltsman Y, Knoll E, Stern N 1998 Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells. Hypertension 32:39-45
4. Ling S, Dai A, Williams MR, Myles K, Dilley RJ, Komesaroff PA, Sudhir K 2002 Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells. Endocrinology 143:1119-1125
5. Hutchison SJ, Sudhir K, Chou TM, Sievers RE, Zhu BQ, Sun YP, Deedwania PC, Glantz SA, Parmley WW, Chatterjee K 1997 Testosterone worsens endothelial dysfunction associated with hypercholesterolemia and environmental tobacco smoke exposure in male rabbit aorta. J Am Coll Cardiol 29:800-807
6. Adams MR, Williams JK, Kaplan JR 1995 Effects of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsiveness. Arterioscler Thromb Vasc Biol 15:562-570
7. Chou TM, Sudhir K, Hutchison SJ, Ko E, Amidon TM, Collins P, Chatterjee K 1996 Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation 94:2614-2619
8. Bernini GP, Moretti A, Sgro M, Argenio GF, Barlascini CO, Cristofani R, Salvetti A 2001 Influence of endogenous androgens on carotid wall in post-menopausal women. Menopause 8:43-50
9. Williams KJ, Tabas I 1995 The response-to-retention hypothesis of early atherogenesis. Arterioscler Thromb Vasc Biol 15:551-561
10. Skalen K, Gustafsson M, Rydberg EK, Hulten LM, Wiklund O, Innerarity TL, Boren J 2002 Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature 417:750-754
11. Vijayagopal P, Figueroa JE, Fontenot JD, Glancy DL 1996 Isolation and characterization of a proteoglycan variant from human aorta exhibiting a marked affinity for low density lipoprotein and demonstration of its enhanced expression in atherosclerotic plaques. Atherosclerosis 127:195-203
12. Wight TN, Heinegard DK, Hascall VC 1991 Proteoglycans: structure and function. In: Hay ED, ed. Cell biology of extracellular matrix. 2nd ed. New York: Plenum Press; 45-77
13. Schonherr E, Jarvelainen HT, Sandell LJ, Wight TN 1991 Effects of platelet-derived growth factor and transforming growth factor-β1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells. J Biol Chem 266:17640-17647
14. Schonherr E, Jarvelainen HT, Kinsella MG, Sandell LJ, Wight TN 1993 Platelet-derived growth factor and transforming growth factor-β1 differentially affect the synthesis of biglycan and decorin by monkey arterial smooth muscle cells. Arterioscler Thromb 13:1026-1036
15. Evartko SP, Raines EW, Ross R, Gold LI, Wight TN 1998 Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-β. Am J Pathol 152:533-546
16. Riessen R, Isner JM, Blessing E, Loushin C, Nikol S, Wight TN 1994 Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries. Am J Pathol 144:962-974
17. Camejo G, Hurt-Camejo E, Olsson U, Bondjers G 1993 Proteoglycans and lipoproteins in atherosclerosis. Curr Opin Lipidol 4:385-391
18. O'Brien KD, Olin KL, Alpers CE, Chiu W, Ferguson M, Hudkins K, Wight TN, Chait A 1998 Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques: colocalization of biglycan with apolipoproteins. Circulation 98:519-527
19. Ballinger M, Nigro J, Frontanilla K, Dart A, Little P 2004 Regulation of glycosaminoglycan structure and atherogenesis. Cell Mol Life Sci 61:1296-1306
20. Little PJ, Tannock L, Olin KL, Chait A, Wight TN 2002 Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor-β1 exhibit increased binding to LDLs. Arterioscler Thromb Vasc Biol 22:55-60
21. Figueroa JE, Vijayagopal P 2002 Angiotensin II stimulates synthesis of vascular smooth muscle cell proteoglycans with enhanced low density lipoprotein binding properties. Atherosclerosis 162:261-268
22. Chang MY, Potter-Perigo S, Tsoi C, Chait A, Wight TN 2000 Oxidized low density lipoproteins regulate synthesis of monkey aortic smooth muscle cell proteoglycans that have enhanced native low density lipoprotein binding properties. J Biol Chem 275:4766-4773
23. Olsson U, Bondjers G, Camejo G 1999 Fatty acids modulate the composition of extracellular matrix in cultured human arterial smooth muscle cells by altering the expression of genes for proteoglycan core proteins. Diabetes 48: 616-622
24. Oparil S, Levine R, Chen Y 1996 Sex hormones and the vasculature. In: Sowers J, ed. Endocrinology of the vasculature. Totowa, NJ: Humana Press; 225-227
25. Sudhir K, Hashimura K, Bobik A, Dilley RJ, Jennings GL, Little PJ 2001 Mechanical strain stimulates a mitogenic response in coronary vascular smooth muscle cells via release of basic fibroblast growth factor. Am J Hypertens 14:1128-1134
26. Nigro J, Dilley RJ, Little PJ 2002 Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells. Atherosclerosis 162:119-129
27. Heinecke JW, Baker L, Rosen H, Chait A 1986 Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. J Clin Invest 77:757-761
28. Chen SJ, Li H, Durand J, Oparil S, Chen YF 1996 Estrogen reduces myointimal proliferation after balloon injury of rat carotid artery. Circulation 93:577-584
29. Sullivan Jr TR, Karas RH, Aronovitz M, Faller GT, Ziar JP, Smith JJ, O'Donnell Jr TF, Mendelsohn ME 1995 Estrogen inhibits the response-to-injury in a mouse carotid artery model. J Clin Invest 96:2482-2488
30. Terry DE, Clark AF 1996 Influence of testosterone on chondroitin sulphate proteoglycan in the rat prostate. Biochem Cell Biol 74:645-651
31. Raychoudhury SS, Blackshaw AW, Irving MG 1993 Rat Sertoli cell extracellular matrix regulates glycosaminoglycan synthesis by peritubular myoid cells in vitro. Mol Reprod Dev 35:151-158
32. Franchimont P, Bassleer C 1991 Effects of hormones and local growth factors on articular chondrocyte metabolism. J Rheumatol 27(Suppl):68-70
33. Kofoed JA, Tumilasci OR, Curbelo HM, Fernandez Lemos SM, Arias NH, Houssay AB 1990 Effect of testosterone on proteoglycans in the submandibular glands of the rat. J Biol Buccale 18:255-259
34. Camejo G, Fager G, Rosengren B, Hurt-Camejo E, Bondjers G 1993 Binding of low density lipoproteins by proteoglycans synthesized by proliferating and quiescent human arterial smooth muscle cells. J Biol Chem 268:14131-14137
35. Edwards IJ, Xu H, Obunike JC, Goldberg IJ, Wagner WD 1995 Differentiated macrophages synthesize a heparan sulfate proteoglycan and an oversulfated chondroitin sulfate proteoglycan that bind lipoprotein lipase. Arterioscler Thromb Vasc Biol 15:400-409
36. Vijayagopal P, Srinivasan SR, Radhakrishnamurthy B, Berenson GS 1981 Interaction of serum lipoproteins and a proteoglycan from bovine aorta. J Biol Chem 256:8234-8241
37. Obasanjo IO, Clarkson TB, Weaver DS 1996 Effects of the anabolic steroid nandrolone decanoate on plasma lipids and coronary arteries of female cynomolgus macaques. Metabolism 45:463-468
38. Ebenbichler CF, Sturm W, Ganzer H, Bodner J, Mangweth B, Ritsch A, Sandhofer A, Lechleitner M, Foger B, Patsch JR 2001 Flow-mediated, endothelium-dependent vasodilatation is impaired in male body builders taking anabolic-androgenic steroids. Atherosclerosis 158:483-490
39. Ng MK, Quinn CM, McCrohon JA, Nakhla S, Jessup W, Handelsman DJ, Celermajer DS, Death AK 2003 Androgens up-regulate atherosclerosis-related genes in macrophages from males but not females: molecular insights into gender differences in atherosclerosis. J Am Coll Cardiol 42:1306-1313