Occlusion of the upper airway does not augment the cardiovascular response to arousal from sleep in humans

Journal of Applied Physiology

Volumn 98, Issue 4, 2005, Pages 1349-1355

  O'Driscoll, Denise M ^a   Kostikas, Konstantinos ^a   Simonds, Anita K ^a   Morrell, Mary J ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Blood pressure; Heart rate

Indexed keywords

AIRWAY OBSTRUCTION; AROUSAL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; MALE; MEAN ARTERIAL PRESSURE; MECHANORECEPTOR; PRIORITY JOURNAL; SLEEP; STATISTICAL SIGNIFICANCE; TIME;

ACOUSTIC STIMULATION; ADULT; AROUSAL; BLOOD PRESSURE; HEART RATE; HUMANS; INHALATION; MALE; PULMONARY VENTILATION; SLEEP; SLEEP APNEA, OBSTRUCTIVE;

EID: 15444371644     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00706.2004     Document Type: Article

References (51)

1. Afifi L, Guilleminault C, and Colrain IM. Sleep and respiratory stimulus specific dampening of cortical responsiveness in OSAS. Respir Physiol Neurobiol 136: 221-234, 2003.
2. Ali NJ, Davies RJ, Fleetham JA, and Stradling JR. The acute effects of continuous positive airway pressure and oxygen administration on blood pressure during obstructive sleep apnea. Chest 101: 1526-1532, 1992.
3. American Society of Hypertension. Recommendations for routine blood pressure measurement by indirect cuff sphygmomanometry. American Society of Hypertension. Am J Hypertens 5: 207-209, 1992.
4. Badr MS, Morgan BJ, Finn L, Toiber FS, Crabtree DC, Puleo DS, and Skatrud JB. Ventilatory response to induced auditory arousals during NREM sleep. Sleep 20: 707-714, 1997.
5. Badr MS, Skatrud JB, Simon PM, and Dempsey JA. Effect of hypercapnia on total pulmonary resistance during wakefulness and during NREM sleep. Am Rev Respir Dis 144: 406-414, 1991.
6. Basner RC, Ringler J, Garpestad E, Schwartzstein RM, Sparrow D, Weinberger SE, Lilly J, and Weiss JW. Upper airway anesthesia delays arousal from airway occlusion induced during human NREM sleep. J Appl Physiol 73: 642-648, 1992.
7. Baydur A, Behrakis PK, Zin WA, Jaeger M, and Milic-Emili J. A simple method for assessing the validity of the esophageal balloon technique. Am Rev Respir Dis 126: 788-791, 1982.
8. Browne HA, Adams L, Simonds AK, and Morrell MJ. Impact of age on breathing and resistive pressure in people with and without sleep apnea. J Appl Physiol 90: 1074-1082, 2001.
9. Buda AJ, Pinsky MM, Ingels NB Jr, Daughters GT, Stinson EB, and Alderman EL. Effect of intrathoracic pressure on left ventricular performance. N Engl J Med 301: 453-459, 1979.
10. Catcheside PG, Chiong SC, Orr RS, Mercer J, Saunders NA, and McEvoy RD. Acute cardiovascular responses to arousal from non-REM sleep during normoxia and hypoxia. Sleep 24: 895-902, 2001.
11. Dampney RA, Coleman MJ, Fontes MA, Hirooka Y, Horiuchi J, Li YW, Polson JW, Potts PD, and Tagawa T. Central mechanisms underlying short- and long-term regulation of the cardiovascular system. Clin Exp Pharmacol Physiol 29: 261-268, 2002.
12. Davenport PW, Friedman WA, Thompson FJ, and Franzen O. Respiratory-related cortical potentials evoked by inspiratory occlusion in humans. J Appl Physiol 60: 1843-1848, 1986.
13. Davies RJ, Belt PJ, Roberts SJ, Ali NJ, and Stradling JR. Arterial blood pressure responses to graded transient arousal from sleep in normal humans. J Appl Physiol 74: 1123-1130, 1993.
14. Eastwood PR, Curran AK, Smith CA, and Dempsey JA. Hemodynamic effects of pressures applied to the upper airway during sleep. J Appl Physiol 89: 537-548, 2000.
15. Garden AL. Myogenic and scalp signals evoked by midinspiratory airway occlusion. J Appl Physiol 89: 422-429, 2000.
16. Gleeson K, Zwillich CW, and White DP. The influence of increasing ventilatory effort on arousal from sleep. Am Rev Respir Dis 142: 295-300, 1990.
17. Henke KG, Dempsey JA, Badr MS, Kowitz JM, and Skatrud JB. Effect of sleep-induced increases in upper airway resistance on respiratory muscle activity. J Appl Physiol 70: 158-168, 1991.
18. Hilton SM. The defence-arousal system and its relevance for circulatory and respiratory control. J Exp Biol 100: 159-174, 1982.
19. 2 levels between sleep and wakefulness. J Physiol 534: 881-890, 2001.
20. Horner RL, Sanford LD, Pack AI, and Morrison AR. Activation of a distinct arousal state immediately after spontaneous awakening from sleep. Brain Res 778: 127-134, 1997.
21. Hwang JC, St John WM, and Bartlett D Jr. Receptors responding to changes in upper airway pressure. Respir Physiol 55: 355-366, 1984.
22. Issa FG, Edwards P, Szeto E, Lauff D, and Sullivan C. Genioglossus and breathing responses to airway occlusion: effect of sleep and route of occlusion. J Appl Physiol 64: 543-549, 1988.
23. Issa FG, McNamara SG, and Sullivan CE. Arousal responses to airway occlusion in sleeping dogs: comparison of nasal and tracheal occlusions. J Appl Physiol 62: 1832-1836, 1987.
24. Issa FG and Sullivan CE. Arousal and breathing responses to airway occlusion in healthy sleeping adults. J Appl Physiol 55: 1113-1119, 1983.
25. Johnson LC and Lubin A. The orienting reflex during waking and sleeping. Electroencephalogr Clin Neurophysiol 22: 11-21, 1967.
26. Kimoff RJ, Sforza E, Champagne V, Ofiara L, and Gendron D. Upper airway sensation in snoring and obstructive sleep apnea. Am J Respir Crit Care Med 164: 250-255, 2001.
27. Kuna ST and Smickley J. Response of genioglossus muscle activity to nasal airway occlusion in normal sleeping adults. J Appl Physiol 64: 347-353, 1988.
28. Larsson H, Carlsson-Nordlander B, Lindblad LE, Norbeck O, and Svanborg E. Temperature thresholds in the oropharynx of patients with obstructive sleep apnea syndrome. Am Rev Respir Dis 146: 1246-1249, 1992.
29. Logan AG, Tkacova R, Perlikowski SM, Leung RS, Tisler A, Floras JS, and Bradley TD. Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex. Eur Respir J 21: 241-247, 2003.
30. McBride B and Whitelaw WA. A physiological stimulus to upper airway receptors in humans. J Appl Physiol 51: 1189-1197, 1981.
31. Mead J and Gaensler EA. Esophageal and pleural pressures in man, upright and supine. J Appl Physiol 14: 81-83, 1959.
32. Mead J and Whittenberger JL. Physical properties of human lungs measured during spontaneous respiration. J Appl Physiol 5: 779-796, 1953.
33. Morgan BJ, Crahtree DC, Puleo DS, Badr MS, Toiber F, and Skatrud JB. Neurocirculatory consequences of abrupt change in sleep state in humans. J Appl Physiol 80: 1627-1636, 1996.
34. 2 between wakefulness and sleep in normal human subjects. J Appl Physiol 78: 1339-1349, 1995.
35. Morrell MJ, Heywood P, Moosavi SH, Stevens J, and Guz A. Central chemosensitivity and breathing asleep in unilateral medullary lesion patients: comparisons to animal data. Respir Physiol 129: 269-277, 2001.
36. 2, brainstem chemoreceptors and breathing. Prog Neurobiol 59: 299-331, 1999.
37. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, Newman AB, Lebowitz MD, and Pickering TG. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 283: 1829-1836, 2000.
38. O'Donnell CP, Allan L, Atkinson P, and Schwartz AR. The effect of upper airway obstruction and arousal on peripheral arterial tonometry in obstructive sleep apnea. Am J Respir Crit Care Med 166: 965-971, 2002.
39. O'Driscoll DM, Meadows GE, Corfield DR, Simonds AK, and Morrell MJ. Cardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans. J Appl Physiol 96: 865-870, 2004.
40. Okabe S, Hida W, Kikuchi Y, Taguchi O, Ogawa H, Mizusawa A, Miki H, and Shirato K. Role of hypoxia on increased blood pressure in patients with obstructive sleep apnoea. Thorax 50: 28-34, 1995.
41. Peppard PE, Young T, Palta M, and Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342: 1378-1384, 2000.
42. Pitson D, Chhina N, Knijn S, van Herwaaden M, and Stradling J. Changes in pulse transit time and pulse rate as markers of arousal from sleep in normal subjects. Clin Sci (Lond) 87: 269-273, 1994.
43. Rechtschaffen A and Kales A. A Manual of Standardized Terminology, Techniques and Scoring Systems for Sleep Stages of Human Subjects. Washington, DC: US Government Printing Office, 1968.
44. Remmers JE, deGroot WJ, Sauerland EK, and Anch AM. Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 44: 931-938, 1978.
45. Ringler J, Garpestad E, Basner RC, and Weiss JW. Systemic blood pressure elevation after airway occlusion during NREM sleep. Am J Respir Crit Care Med 150: 1062-1066, 1994.
46. Somers VK, Mark AL, Zavala DC, and Abboud FM. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 67: 2101-2106, 1989.
47. Sweazey RD and Bradley RM. Responses of neurons in the lamb nucleus tractus solitarius to stimulation of the caudal oral cavity and epiglottis with different stimulus modalities. Brain Res 480: 133-150, 1989.
48. Trinder J, Allen N, Kleiman J, Kralevski V, Kleverlaan D, Anson K, and Kim Y. On the nature of cardiovascular activation at an arousal from sleep. Sleep 26: 543-551, 2003.
49. Trinder J, Padula M, Berlowitz D, Kleiman J, Breen S, Rochford P, Worsnop C, Thompson B, and Pierce R. Cardiac and respiratory activity at arousal from sleep under controlled ventilation conditions. J Appl Physiol 90: 1455-1463, 2001.
50. Wheatley JR, Tangel DJ, Mezzanotte WS, and White DP. Influence of sleep on response to negative airway pressure of tensor palatini muscle and retropalatal airway. J Appl Physiol 75: 2117-2124, 1993.
51. Wheatley JR and White DP. Influence of NREM sleep on respiratory-related cortical evoked potentials in normal humans. J Appl Physiol 74: 1803-1810, 1993.