Aging does not alter the mechanosensitivity of the p38, p70S6k, and JNK2 signaling pathways in skeletal muscle

Journal of Applied Physiology

Volumn 98, Issue 4, 2005, Pages 1562-1566

  Hornberger, Troy A ^a,c   Mateja, R D ^a   Chin, E R ^b   Andrews, J L ^a   Esser, K A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Atrophy; Growth; Hypertrophy; Mechanotransduction; Stretch

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; S6 KINASE; STRESS ACTIVATED PROTEIN KINASE;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATROPHY; ENZYME PHOSPHORYLATION; EXTENSOR DIGITORUM LONGUS MUSCLE; HYPERTROPHY; MALE; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; MOUSE; MUSCLE GROWTH; MUSCLE MASS; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; STIMULUS RESPONSE; TRANSCRIPTION REGULATION;

AGING; ANIMALS; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 9; MUSCLE, SKELETAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHYSICAL STIMULATION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;

EID: 15444370116     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00870.2004     Document Type: Article

References (23)

1. Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, and Yancopoulos GD. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3: 1014-1019, 2001.
2. Carlson BM and Faulkner JA. Muscle transplantation between young and old rats: age of host determines recovery. Am J Physiol Cell Physiol 256: C1262-C1266, 1989.
3. Doherty TJ, Vandervoort AA, Taylor AW, and Brown WF. Effects of motor unit losses on strength in older men and women. J Appl Physiol 74: 868-874, 1993.
4. Hornberger TA, Hunter RB, Kandarian SC, and Esser KA. Regulation of translation factors during hindlimb unloading and denervation of skeletal muscle in rats. Am J Physiol Cell Physiol 281: C179-C187, 2001.
5. Hornberger TA, Stuppard R, Conley KE, Fedele MJ, Fiorotto ML, Chin ER, and Esser KA. Mechanical stimuli regulate rapamycin-sensitive signaling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochem J 380: 795-804, 2004.
6. Institute of Laboratory Animal Resources (U.S.). Committee on Animal Models for Research on Aging. Mammalian Models for Research on Aging. Washington, DC: National Academy, 1981.
7. Jozsi AC, Dupont-Versteegden EE, Taylor-Jones JM, Evans WJ, Trappe TA, Campbell WW, and Peterson CA. Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise. Mech Ageing Dev 120: 45-56, 2000.
8. Li M, Li C, and Parkhouse WS. Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle. Mech Ageing Dev 124: 771-778, 2003.
9. Machida S and Booth FW. Regrowth of skeletal muscle atrophied from inactivity. Med Sci Sports Exerc 36: 52-59, 2004.
10. Martineau LC and Gardiner PF. Skeletal muscle is sensitive to the tension-time integral but not to the rate of change of tension, as assessed by mechanically induced signaling. J Biomech 35: 657-663, 2002.
11. Maxwell LC, Faulkner JA, and Hyatt GJ. Estimation of number of fibers in guinea pig skeletal muscles. J Appl Physiol 37: 259-264, 1974.
12. Mendez RA and Keys A. Density and composition of mammalian muscle. Metabolism 9: 184-188, 1960.
13. Morris RT, Spangenburg EE, and Booth FW. Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle. J Appl Physiol 96: 398-404, 2004.
14. Parkington JD, LeBrasseur NK, Siebert AP, and Fielding RA. Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle. J Appl Physiol 97: 243-248, 2004.
15. Pattison JS, Folk LC, Madsen RW, and Booth FW. Selected Contribution: Identification of differentially expressed genes between young and old rat soleus muscle during recovery from immobilization-induced atrophy. J Appl Physiol 95: 2171-2179, 2003.
16. Proctor DN, Balagopal P, and Nair KS. Age-related sarcopenia in humans is associated with reduced synthetic rates of specific muscle proteins. J Nutr 128: 351S-355S, 1998.
17. Reeds PJ, Palmer RM, and Smith RH. Protein and collagen synthesis in rat diaphragm muscle incubated in vitro: the effect of alterations in tension produced by electrical or mechanical means. Int J Biochem 11: 7-14, 1980.
18. Ruwhof C and van der Laarse A. Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovasc Res 47: 23-37, 2000.
19. Sugden PH. Signalling pathways in cardiac myocyte hypertrophy. Ann Med 33: 611-622, 2001.
20. Thomas G and Hall MN. TOR signalling and control of cell growth. Curr Opin Cell Biol 9: 782-787, 1997.
21. Williamson D, Gallagher P, Harber M, Hollon C, and Trappe S. Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. J Physiol 547: 977-987, 2003.
22. Willis PE, Chadan S, Baracos V, and Parkhouse WS. Acute exercise attenuates age-associated resistance to insulin-like growth factor I. Am J Physiol Endocrinol Metab 272: E397-E404, 1997.
23. Zarzhevsky N, Carmeli E, Fuchs D, Coleman R, Stein H, and Reznick AZ. Recovery of muscles of old rats after hindlimb immobilisation by external fixation is impaired compared with those of young rats. Exp Gerontol 36: 125-140, 2001.