Classification of the mode of inhibition of high-affinity choline uptake using capillary electrophoresis with electrochemical detection at an enzyme-modified microelectrode

Analytical Biochemistry

Volumn 339, Issue 2, 2005, Pages 216-222

  Barkhimer, Tatyana V ^a   Kirchhoff, Jon R ^a   Hudson, Richard A ^a,b   Messer Jr , William S ^b  

^a UNIVERSITY OF TOLEDO   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Capillary electrophoresis; Choline uptake assay; Classification of inhibition; Electrochemical detection; Enzyme electrode

Indexed keywords

CAPILLARY ELECTROPHORESIS; CHEMICAL DETECTION; ENZYME ELECTRODES; MICROELECTRODES; PHENOLS;

ELECTROCHEMICAL DETECTION; HIGH AFFINITY; IN-VITRO ASSAYS; QUATERNARY AMMONIUM; SUBSTRATE CONCENTRATIONS;

ENZYME INHIBITION;

3 [(TRIMETHYLAMMONIO)METHYL]CATECHOL; 6 HYDROXY N,N DIMETHYLEPINEPHRINE; AMMONIUM DERIVATIVE; CATECHOL DERIVATIVE; HEMICHOLINIUM 3; N,N DIMETHYLADRENALIN; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHOLINE UPTAKE; CONTROLLED STUDY; DRUG SCREENING; ELECTROCHEMICAL DETECTION; ENZYME MODIFICATION; IN VITRO STUDY; INTERMETHOD COMPARISON; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SYNAPTOSOME;

EID: 15444367787     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2005.01.047     Document Type: Article

References (31)

1. M.F. Bear, B.W. Connors, M.A. Paradiso, Neuroscience: Exploring the Brain, second ed., Lippincott Williams & Wilkins, Baltimore, MD, 2001, p. 141
2. R.E. Thompson, The Brain: A Neuroscience Primer, second ed., W.H. Freeman, New York, 1993, p. 117
3. J.R. Cooper, F.E. Bloom, R.H. Roth, The Biochemical Basis of Neuropharmacology, Oxford University Press, New York, 1991, p. 190
4. D.S. Auld, T.M. Kornecook, S. Bastianetto, and R. Quirion Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies Prog. Neurobiol. 68 2002 209 245
5. G.S. Zubenko Molecular neurobiology of Alzheimer's disease (syndrome?) Harv. Rev. Psychiatry 5 1997 177 213
6. H. Henke, and W. Lang Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients Brain Res. 267 1983 281 291
7. B.J. Nickoloff, M. Grimes, E.R. Wohlfeil, and R.A. Hudson Affinity-dependent cross-linking to neurotoxin sites of the acetylcholine receptor mediated by catechol oxidation Biochemistry 24 1985 999 1007
8. P.J. Patel, E.R. Wohlfeil, S.S. Stahl, K.A. McLaughlin, and R.A. Hudson Redox reactive reagents inhibiting and inactivating choline acetyltransferase Biochem. Biophys. Res. Commun. 175 1991 407 413
9. P.J. Patel, W.S. Messer Jr., and R.A. Hudson Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs J. Med. Chem. 36 1993 1893 1901
10. Y. Gu, H. Lee, J.R. Kirchhoff, L. Manzey, and R.A. Hudson Mechanism of action of the redox affinity reagent [(trimethylammonio)methyl]catechol Biochemistry 33 1994 8486 8494
11. Y. Gu, H. Lee, and R.A. Hudson bis-Catechol-substituted redox-reactive analogues of hexamethonium and decamethonium: stimulated affinity-dependent reactivity through iron peroxide catalysis J. Med. Chem. 37 1994 4417 4420
12. R. Shen, L.M.V. Tillekeratne, J.R. Kirchhoff, and R.A. Hudson 6-Hydroxycatecholine, a choline-mimicking analogue of the selective neurotoxin, 6-hydroxydopamine Biochem. Biophys. Res. Commun. 228 1996 187 192
13. I. Hanin Choline and acetylcholine: Handbook of chemical assay methods 1974 Raven Press New York
14. I. Yamamura, and S.H. Snyder High affinity transport of choline into synaptosomes of rat brain J. Neurochem. 21 1973 1355 1374
15. 14C]acetylcholine in synaptosomes J. Neurochem. 18 1971 781 798
16. 14C]choline into synaptosomes in vitro Biochem. J. 110 1968 533 541
17. 11C]choline Brain Res. Protoc. 10 2002 1 11
18. S. Kar, A.M. Issa, D. Seto, D.S. Auld, B. Collier, and R. Quirion Amyloid β-peptide inhibits high-affinity choline uptake and acetylcholine release in rat hippocampal slices J. Neurochem. 70 1998 2179 2187
19. M. Tamaru, E. Roberts, and I. Structure Activity studies on inhibition of choline uptake by a mouse brain synaptosomal preparation: basic data Brain Res. 473 1988 205 226
20. D.D. Wise, T.V. Barkhimer, J.R. Kirchhoff, W.S. Messer Jr., and R.A. Hudson Internal standard method for the measurement of choline and acetylcholine by capillary electrophoresis with electrochemical detection J. Chromatogr. B 775 2002 49 56
21. T.V. Barkhimer, J.R. Kirchhoff, R.A. Hudson, and W.S. Messer Jr. Evaluation of the inhibition of choline uptake in synaptosomes by capillary electrophoresis with electrochemical detection Electrophoresis 23 2002 3699 3704
22. A. LaManna, and A. Campiglio Resolution of the optical isomers of N-methyladrenalin Farmaco Ed. Sci. 14 1959 317 322
23. A.R. Smith, J.R. Kirchhoff, L.M.V. Tillekeratne, and R.A. Hudson Separation of negatively charged isomeric quinones by capillary electrophoresis with reductive electrochemical detection in acidic media Anal. Commun. 36 1999 371 374
24. A.M. Fermier, M.L. Gostkowski, and L.A. Colon Rudimentary capillary-electrode alignment for capillary electrophoresis with electrochemical detection Anal. Chem. 68 1998 1661 1664
25. M.C. Linhares, and P.T. Kissinger Use of an on-column fracture in capillary zone electrophoresis for sample introduction Anal. Chem. 63 1991 2076 2078
26. E.G. Gray, and V.P. Whittaker The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation J. Anat. 96 1962 79 88
27. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
28. I.M. Segal Enzyme kinetics 1975 Wiley New York p. 175
29. M. Marchi, F. Bergaglia, A. Pedrini, and M. Raiteri Study of the bidirectional transport of choline by blocking choline carriers from outside or inside brain nerve terminals J. Neurosci. Res. 61 2000 533 540
30. L.A. Barker, and T.W. Mittag Comparative studies of substrates and inhibitors of choline transport and choline acetyltransferase J. Pharmacol. Exp. Ther. 192 1975 86 94
31. J.R. Cooper, F.E. Bloom, R.H. Roth, The Biochemical Basis of Neuropharmacology, Oxford University Press, New York, 1991, p. 194