Cardiovascular effects of (2RS, 3SR)-2-aminomethyl-2,3,7,8-tetrahydro- 2,3,5,8,8-pentamethyl-6H-furo-[2,3-e]indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties

Arzneimittel-Forschung/Drug Research

Volumn 48, Issue 3, 1998, Pages 219-231

  Uchida, Yasumi ^a   Kawada, Mitsuo ^b   Sawanobori, Kimio ^b   Sonoki, Hiroyuki ^b   Inoue, Keisuke ^b   Mizuno, Ken ^b   Itou, Takahiro ^b   Tabunoki, Yuichiro ^b   Tsukamoto, Masami ^b   Ohashi, Yosuke ^b   Kyotani, Yoshinori ^b   Shimizu, Noboru ^b   Fujii, Mikio ^b   Nakamura, Masaki ^b  

^a TOHO UNIVERSITY   (Japan)

^b KOWA COMPANY LTD   (Japan)

Author keywords

(2RS,3SR) 2 Aminomethyl 2,3,7,8 tetrahydro 2,3,5,8,8 pentamethyl 6H furo 2,3 e indol 7 one hydrochloride; CAS 170684 14 7; CAS 81840 15 5; UK 1745, cardiovascular effects; Vesnarinone

Indexed keywords

2 AMINOMETHYL 2,3,7,8 TETRAHYDRO 2,3,5,8,8 PENTAMETHYL 6H FURO[2,3-E]INDOL 7 ONE; CARDIOTONIC AGENT; PIPERANOMETOZINE; UNCLASSIFIED DRUG;

ACUTE HEART FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CHRONOTROPISM; CONGESTIVE HEART FAILURE; CORONARY ARTERY DILATATION; DOG; DOSE RESPONSE; GUINEA PIG; HEART LEFT ATRIUM; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CONTRACTILITY; HEART OUTPUT; HEART PACING; INOTROPISM; NONHUMAN; VASCULAR RESISTANCE; VASODILATATION;

ANESTHESIA; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; CARDIOTONIC AGENTS; DOGS; FEMALE; GUINEA PIGS; HEART; HEART ATRIA; HEART RATE; HEMODYNAMIC PROCESSES; INDOLES; MALE; MICE; MICE, INBRED ICR; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; SINOATRIAL NODE; VASODILATOR AGENTS;

EID: 15444348051     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Packer, M., Medina, N., Yushak, M., Circulation 70, 1038 (1984)
2. Packer, M., Carver, J. R., Rodeheffer, R. J. et al., N. Engl. J. Med. 325, 1468 (1991)
3. Uretsky, B. F., Jessup, M., Konstam, M. A. et al., Circulation 82, 774 (1990)
4. Goldman, S., Johnson, G., Cohn, J. N. et al., Circulation 87 (Suppl. VI), VI-24 (1993)
5. Massie, B. M., Conway, M., Circulation 75 (Suppl. IV), IV-11 (1987)
6. Feldman, A. M., Bristow, M. R., Parmley, W. W. et al., N. Engl. J. Med. 329, 149 (1993)
7. The CONSENSUS trial study group, N. Engl. J. Med. 316, 1429 (1987)
8. The SOLVED investigators, N. Engl. J. Med. 325, 293 (1991)
9. Cohn, J. N., Jonson, G., Ziesche, S. et al., N. Engl. J. Med. 325, 303 (1991)
10. Engelmeier, R. S., O'Connel, J. B., Walsh, R. et al., Circulation 72, 536 (1985)
11. Anderson, J. L., Lutz, J. R., Gilbert, E. M. et al., Am. J. Cardiol. 55, 471 (1985)
12. Cohn, J. N., Circulation 78, 1099 (1988)
13. Lee, R. J., Evans, D. B., Baky, S. H. et al., Eur. J. Pharmacol. 33, 371 (1975)
14. Kubota, K., Hashimoto, K., Naunyn-Schmiedeberg's Arch. Pharmacol. 278, 135 (1973)
15. Endoh, M., Hashimoto, K., Am. J. Physiol. 218, 1459 (1970)
16. Taylor, R. R., Ross, J. JR., Covell, J. W. et al., Circulation 21, 99 (1967)
17. Mason, D. T., Spann, J. F. JR., Zelis, R., Am. J. Cardiol. 26, 248 (1970)
18. Weiss, J. L., Frederiksen, J. W., Weisfeldt, M. L., J. Clin. Invest. 58, 751 (1976)
19. Kumada, T., Karliner, J. S., Pouleur, H. et al., Am. J. Physiol. 273, H542 (1979)
20. Lawson, J. W., J. Pharmacol. Exp. Ther. 160, 22 (1968)
21. Litchfield, J. T. JR., Wilcoxon, F., J. Pharmacol. Exp. Ther. 96, 99 (1949)
22. Satoh, Y., Wada, Y., Taira, N., Heart Vessels 2, 213 (1986)
23. Imagawa, J., Satoh, K., Taira, N., Heart Vessels 3, 182 (1987)
24. Hosono, M., Taira, N., J. Cardiovasc. Pharmacol. 10, 692 (1987)
25. Taira, N., Endoh, M., Iijima, T. et al., Arzneim.-Forsch./Drug Res. 34(1), 3a, 347 (1984)
26. Kamijo, T., Tomaru, T., Miwa, A. Y. et al., Jpn. J. Pharmacol. 65, 223 (1994)
27. Uchida, Y., Sonoki, H., Jpn. J. Pharmacol. 71 (Suppl. I), 227P (1996)
28. Uchida, Y., Sonoki, H., FASEB J. 10, pp A432 (1996)
29. Hashimoto, K., Mitsuhashi, H., Br. J. Pharmacol. 88, 915 (1986)
30. Trolese-Mongheal, Y., Barthelemy, J., Paire, M. et al., Gen. Pharmacol. 23, 95 (1992)
31. Kawada, M., Sawanobori, K., Sonoki, H. et al., Jpn. J. Pharmacol. 71 (Suppl. I), 229P (1996)
32. Sawanobori, K., Kawada, M., Sonoki, H. et al., FASEB J. 10, pp A431 (1996)
33. Uemura, H., Sakamoto, N., Nakaya, H., Jpn. J. Pharmacol. 73 (Suppl. I), 233P (1997)
34. Sawada, H., Endoh, M., J. Mol. Cell. Cardiol. 29, A301 (1997)