ARDS model in the rat: influence of early and late treatment with surfactant in an animal model of acute lung injury

Arzneimittel-Forschung/Drug Research

Volumn 48, Issue 3, 1998, Pages 318-320

  Hafner, Dietrich ^a   Germann, Paul Georg ^a   Hauschke, Dieter ^a  

^a ALTANA PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 15444347035     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Gregory, T. J., Longmore, W. I, Moxley, M. A. et al., Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. J. Clin. Invest. 88, 1976 (1991)
2. Günther, A., Siebert, C, Schmidt, R. et al., Surfactant alterations in severe pneumonia, acute respiratory distress syndrome and cardiogenic lung edema. Am. J. Respir. Crit. Care Med. 153, 176 (1996)
3. Lewis, J. F., Jobe, A. H., Surfactant and the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 147, 218 (1993)
4. Kawano, T., Mori, S., Cybulsky, M. et al., Effect of granulocyte depletion in a ventilated surfactant-depleted lung. J. Appl. Physiol. 62, 27 (1987)
5. Hafner, D., German, P.-G., Hauschke, D., Effects of lung surfactant factor (LSF) treatment on gas exchange and histopathological changes in an animal model of adult respiratory distress syndrome (ARDS). Comparison of recombinant LSF with bovine LSF. Pulm. Pharmacol. 7, 319 (1994)
6. Hafner, D., Beume, R., Kilian, U. et al., Dose response comparisons of five lung surfactant factor (LSF) preparations in an animal model of adult respiratory distress syndrome (ARDS). Br. J. Pharmacol. 115, 451 (1995)
7. Ito, Y, Goffin, J., Veldhuizen, R. et al., Timing of exogenous surfactant administration in a rabbit model of acute lung injury. J. Appl. Physiol. 80, 1357 (1996)
8. Lewis, J. F., Veldhuizen, R. A. W, Factors influencing efficacy of exogenous surfactant in acute lung injury. Biol. Neonate. 67 (Suppl.), 48 (1995)