High prevalence of normal total calcium and intact PTH in 60 patients with proven primary hyperparathyroidism: A challenge to current diagnostic criteria

Australian and New Zealand Journal of Medicine

Volumn 28, Issue 2, 1998, Pages 173-178

  Glendenning, P ^a   Gutteridge, D H ^a   Retallack, R W ^b   Stuckey, B G A ^c   Kermode, D G ^d   Kent, G N ^a  

^a Sir Charles Gairdner Hospital   (Canada)

^b Division of Clinical Pathology   (Canada)

^c SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^d King Edward Hospital   (Australia)

Author keywords

Hypercalcaemia; Intact PTH; Ionised calcium; Primary hyperparathyroidism

Indexed keywords

CALCIUM ION; PARATHYROID HORMONE; PHOSPHATE;

ADULT; AGED; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM URINE LEVEL; CONTROLLED STUDY; FEMALE; HORMONE DETERMINATION; HUMAN; HYPERCALCEMIA; HYPERPARATHYROIDISM; MAJOR CLINICAL STUDY; MALE; PARATHYROID ADENOMA; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROID HYPERPLASIA; PHOSPHATE URINE LEVEL; PREVALENCE; THYROID HYPERPLASIA;

ADULT; AGED; CALCIUM; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPERPARATHYROIDISM; KIDNEY; MALE; MIDDLE AGED; PARATHYROID HORMONE; PHOSPHATES; RETROSPECTIVE STUDIES;

EID: 15444346256     PISSN: 00048291     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Lafferty FW. Differential diagnosis of hypercalcemia. J Bone Miner Res 1991; 6 (Suppl. 2): S51-S59.
2. Alundy GR, Cove DH, Fisken R. Primary hyperparathyroidism: changes in the pattern of clinical presentation. Lancet 1980; i: 1317-21.
3. Kaplan EL, Yashiro T, Salti G. Primary hyperparathy-roidism in the 1990's -choice of surgical procedures for this disease. Ann Surg 1992; 215: 300-17.
4. Logue FC, Beastall GH, Fraser WD, O'Reilly DS. Intact parathyroid hormone assays. Br Med J 1990; 300: 210-11.
5. Nussbaum SR, Potts JT Immunoassays for parathyroid hormone 1-84 in the diagnosis of primary hyperparathy-roidism. J Bone Miner Res 1991; 6 (Suppl. 2): S43-S50.
6. Endres DB, Villanueva R, Sharp CF, Singer FR. Immunochemiluminometric and immunoradiometric determinations of intact and total immunoreactive parathyrin: performance in the differential diagnosis of hypercalcaemia and hypoparathyroidism. Clin Chem 1991; 37: 162-8.
7. Bergenfelz A, Valdermarsson S, Ahren B. Measurement of intact PTH in the diagnosis of primary hyperparathy-roidism. Acta Endocrinol (Copenh) 1991; 125: 668-74.
8. Brown RC, Aston JP, Weeks I, Woodhead JS. Circulating intact parathyroid hormone measured by a two-site immunochemiluminometric assay. J Clin Endocrinol Metab 1987; 65: 407-14.
9. Minisola S, Scarnecchia L, Romagnoli E et al. Conventional and new diagnostic applications of a two-site immunochemiluminometric assay for parathyroid hormone. J Endocrinol Invest 1992; 15: 483-9.
10. Nordin BEC. In: Nordin BEC (Ed.). Calcium, phosphate and magnesium metabolism. Edinburgh: Churchill Livingstone, 1976: 469-500.
11. Prince RL, Dick I, Devine A et al. The effects of menopause and age on calcitropic hormones: a cross-sectional study of 655 healthy women aged 35 to 90. J Bone Miner Res 1995; 10: 835-42.
12. Nordin BEC, Need AG, Morris HA et al. Evidence for a renal calcium leak in postmenopausal women. J Clin Endocrinol Metab 1991; 72: 401-11.
13. Stuckey EGA, Gutteridge DH, Keogh EJ. 1996. Unpublished data.
14. Avramides A, Leonidas J-R, Chen C-K, Nicastri A. Coexistence of Paget's disease and hyperparathyroidism. NY State J Med 1981; 10: 1660-2.
15. Gutteridge DH, Gruber H, Retallack RW et al. Paget's disease with hyperparathyroidism: The Paget's response to parathyroidectomy. Calcif Tiss Internat 1981; Suppl.: 94.
16. Glendenning P, Pullan PT, Gulland D, Edis AJ. Surgically proven primary hyperparathyroidism with a suppressed intact parathyroid hormone. Med J Aust 1996; 165: 197-8.
17. National Institutes of Health. Diagnosis and management of asymptomatic primary hyperparathyroidism consensus statement. J Bone Miner Res 1991; 6 (Suppl. 2):S9-S13.
18. Thode J, Juul-Jórgensen B, Bhatia HM et al. Comparison of serum total calcium, albumin-corrected total calcium and ionised calcium in 1213 patients with suspected calcium disorders. Scand J Clin Lab Invest 1989; 49: 217-23.
19. Ladenson JH. Calcium determination in primary hyperparathyroidism. J Bone Miner Res 1991; 6 (Suppl. 2): S33-S41.
20. Khosla S, Ebeling PR, Firek AF, Burrit MM, Kao PC, Heath H. Calcium infusion suggests a 'set point' abnormality of parathyroid function in familial benign hypercalcaemia and more complex disturbances in primary hyperparathyroidism. J Clin Endocrinol Metab 1993; 76: 715-20.
21. Hollenberg AN, Arnold A. Hypercalcemia with lownormal serum intact PTH: a novel presentation of primary hyperparathyroidism. Am J Med 1991; 91: 547-8.
22. Peacock M. Interpretation of bone mass determinations as they relate to fracture: implications for asymptomatic primary hyperparathyroidism. J Bone Miner Res 1991; 6 (Suppl. 2): S77-S82.
23. Silverberg SJ, Gartenberg F, Jacobs TP et al. Longitudinal measurements of bone density and biochemical indices in untreated primary hyperparathyroidism. J Clin Endocrinol Metab 1995; 80: 723-8.
24. Silverberg SJ, Gartenberg F, Jacobs TP et al. Increased bone mineral density after parathyroidectomy in primary hyperparathyroidism. J Clin Endocrinol Metab 1995; 80: 729-34.
25. Silverberg SJ, Locker FG, Bilezikian JP. Vertebral osteopenia: a new indication for surgery in primary hyperparathyroidism. J Clin Endocrinol Metab 1996; 81: 4007-12.
26. Dangelo A, Lodetti MG, Giannini S et al. Hyperparathyroidism - cause or consequence of recurrent calcium nephrolithiasis. Miner Elec Metab 1993; 18: 359-64.
27. Vandoorn L, Lips P, Netelenbos JC, Hackeng WHL. Bone histomorphometry and serum concentration of intact parathyroid hormone (PTH(1-84)) in patients with primary hyperparathyroidism. Bone Miner 1993; 23: 233-42.
28. Soin AS, Gupta S, Kochupillai N, Sharma LK. Primary hyperparathyroidism - an Indian study. Ind J Cancer 1994; 31: 72-7.
29. Robinson G. The importance of distinguishing FHH from asymptomatic primary hyperparathyroidism prior to neck exploration. Clin Otolaryngol 1990; 15: 141-6.
30. St John A, Stuckey EGA, Kent GN et al. Intact PTH levels in patients with familial hypocalciuric hypercalcemia. Clin Biochem Rev 1989; 10: 94.