BMS-190394, a selectin inhibitor, prevents rat cutaneous inflammatory reactions

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 3, 1997, Pages 1298-1304

  Todderud, Gordon ^a   Nair, Xina ^a   Lee, Debbie ^a   Alford, Julie ^a   Davern, Lynda ^a   Stanley, Paul ^a   Bachand, Carol ^b   Lapointe, Philippe ^b   Marinier, Anne ^b   Martel, Alain ^b   Menard, Marcel ^b   Wright, John J ^a   Bajorath, Jurgen ^a   Hollenbaugh, Diane ^a   Aruffo, Alejandro ^a   Tramposch, Kenneth M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Bristol Myers Squibb Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BMS 190394; DEXAMETHASONE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; L SELECTIN; NATURAL PRODUCT; PADGEM PROTEIN; SELECTIN; SELECTIN INHIBITOR; SULFATIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHUS PHENOMENON; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG HALF LIFE; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SKIN INFLAMMATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHUS REACTION; E-SELECTIN; HL-60 CELLS; HUMANS; HYPERSENSITIVITY, DELAYED; L-SELECTIN; MALE; NEUTROPHILS; P-SELECTIN; RATS; RATS, SPRAGUE-DAWLEY; SULFOGLYCOSPHINGOLIPIDS;

EID: 15444345968     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. ABBASSI, O., KISHIMOTO, T. K., MCINTIRE, L. V., ANDERSON, D. C. AND SMITH, C. W.: E-selectin supports neutrophil rolling in vitro under conditions of flow. J. Clin. Invest. 92: 2719-2730, 1993.
2. ARUFFO, A., KOLANUS, W., WALZ, G., FREDMAN, P. AND SEED, B.: CD62/P-selectin recognition of myeloid and tumor cell sulfatides. Cell 67: 35-44, 1991.
3. ARUFFO, A., DIETSCH, M. T., WAN, H., HELLSTROM, K. E. AND HELLSTROM, I.: Granule membrane protein 140 (GMP-140) binds to carcinomas and carcinoma-derived cell lines. Proc. Natl. Sci. U.S.A. 89: 2292-2296, 1992.
4. ARUFFO, A., STAMENKOVIC, I., MELNICK, M., UNDERHILL, C. B. AND SEED, B.: CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303-1313, 1990.
5. BERLIN, C., BARGATZE, R. F., CAMPBELL, J. J., VON ANDRIAN, U. H., SZABO, M. C., HASSLEN, S. R., NELSON, R. D., BERG, E. L., ERLANDSEN, S. L. AND BUTCHER, E. C.: Alpha4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80: 413-422, 1995.
6. BRADLEY, P. P., PRIEBAT, D. A., CHRISTENSEN, R. D. AND ROTHSTEIN, G.: Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol. 78: 206-209, 1982.
7. BRANDLEY, B. K., KISO, M., ABBAS, S., NIKRAD, P., SRIVASATAVA, O., FOXALL, C., ODA, Y. AND HASEGAWA, A.: Structure-function studies on selectin carbohydrate ligands. Modifications to fucose, sialic acid and sulfate as a sialic acid replacement. Glycobiology 3: 633-641, 1993.
8. CAVEY, D., BOUCLIER, M., BURG, G., DELAMADELEINE, F. AND HENSBY, C. N.: The pharmacological modulation of delayed type hypersensitivity (DTH) reactions to topical oxazolone in mouse skin. Agents and Actions 29: 65-67, 1990.
9. CECCONI, O., NELSON, R. M., ROBERTS, W. G., HANASAKI, K., MANNORI, G., SCHULTZ, C., ULICH, T. R., ARUFFO, A. AND BEVILACQUA, M. P.: Inositol polyanions. Noncarbohydrate inhibitors of L-and P-selectin that block inflammation. J. Biol. Chem. 269: 15060-15066, 1994.
10. CHAPMAN, J. R., RUBEN, Z. AND BUTCHKO, G. M.: Histology of and quantitative assays for oxazolone-induced allergic contact dermatitis in mice. Amer. J. Dermatopathol. 8: 130-138, 1986.
11. COCHRANE, C. G., AIKIN, B. S.: Polymorphonuclear leukocytes in immunologic reactions. The destruction of vascular basement membrane in vivo and in vitro. J. Exp. Med. 124: 733-752, 1966.
12. DEGRENDELE, H. C., ESTESS, P., PICKER, L. J. AND SIEGELMAN, M. H.: CD44 and its ligand hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial cell primary adhesion pathway. J. Exp. Med. 183:1119-1130, 1996.
13. 4-induced liver inflammation in rats. Biosci. Biotech. Biochem. 59: 155-157, 1995.
14. LABOW, M. A., NORTON, C. R., RUMBERGER, J. M., LOMBARD-GILLOOLY, K. M., SHUSTER, D. J., HUBBARD, J., BERTKO, R., KNAACK, P. A., TERRY, R. W., HARBISON, M. L., KONTGEN, F., STEWART, C. L., MCINTYRE, K. W., WILL, P. C., BURNS, D. K. AND WOLITZKY, B. A.: Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selecting. Immunity 1: 709-720, 1994.
15. LASKY, L.: Selectin-carbohydrate interactions and the initiation of the inflammatory response. Annu. Rev. Biochem. 64: 113-139, 1995.
16. LAWRENCE, M. B. AND SPRINGER, T. A.: Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins. Cell 65: 859-873, 1991.
17. LEWIS, R. A., AUSTEN, K. F. AND SOBERMAN, R. J.: Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N. Engl. J. Med. 323: 645-655, 1990.
18. MAYADAS, T. N., JOHNSON, R. C., RAYBURN, H., HYNES, R. O. AND WAGNER, D. D.: Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74: 551-554, 1993.
19. MOUSA, S. A.: Recent advances in cell adhesion molecule (CAM) research and development: Targeting CAMs for therapeutic and diagnostic applications. Drugs Future 21: 283-289, 1996.
20. MULLIGAN, M. S., MIYASAKA, M., SUZUKI, M., KAWASHIMA, H., IIZUKA, M., HASEGAWA, A., KISO, M., WARNER, R. L. AND WARD, P. A.: Anti-inflammatory effects of sulfatides in selectin-dependent acute lung injury. Int. Immunol. 7: 1107-1113, 1995.
21. MULLIGAN, M. S., PAULSON, J. C., DE FREES, S., ZHENG, Z. L., LOWE, J. B. AND WARD, P. A.: Protective effects of oligosaccharides in P-selectin-dependent lung injury. Nature 364: 149-151, 1993.
22. MULLIGAN, M. S., VARANI, J., DAME, M. K., LANE, C. L., SMITH, C. W., ANDERSON, D. C. AND WARD, P. A.: Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J. Clin. Invest. 88: 1396-1406, 1991.
23. NAIR, X., TODDERUD, G., DAVERN, L., LEE, D., ARUFFO, A. AND TRAMPOSCH, K. M.: Inhibition of immune complex-induced inflammation by a small molecular weight selectin antagonist. Mediators of Inflammation 3: 459-463, 1994.
24. NELSON, R. M., CECCONI, O., ROBERTS, W. G., ARUFFO, A., LINHARDT, R. J. AND BEVILACQUA, M. P.: Heparin oligosaccharides bind L-and P-selectin and inhibit acute inflammation. Blood 82: 3253-3258, 1993.
25. RAO, B. N., ANDERSON, M. B., MUSSER, J. H., GILBERT, J. H., SCHAEFER, M. E., FOXALL, C. AND BRANDLEY, B. K.: Sialyl Lewis X mimics derived from a pharmacophore search are selectin inhibitors with anti-inflammatory activity. J. Biol. Chem. 269: 19663-19666, 1994.
26. SILBER, A., NEWMAN, W., SASSEVILLE, V. G., PAULEY, D., BEALL, D., WALSH, D. G. AND RINGLER, D. J.: Recruitment of lymphocytes during cutaneous delayed hypersensitivity in nonhuman primates is dependent on E-selectin and vascular cell adhesion molecule 1. J. Clin. Invest. 93: 1554-1563, 1994.
27. VON ANDRIAN, U. H., CHAMBERS, J. D., MCEVOY, L. M., BARGATZE, R. F., ARFORS, K. E. AND BUTCHER, E. C.: Two-step model of leukocyte-endothelial cell interaction in inflammation: Distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo. Proc. Natl. Acad. Sci. U.S.A. 88: 7538-7542, 1991.
28. x determinant on myeloid and tumor cells. Science (Wash, DC) 250: 1132-1135, 1990.
29. WATSON, S. R., IMAI, Y., FENNIE, C., GEOFFROY, J. S., ROSEN, S. D. AND LASKY, L. A.: A homing receptor-IgG chimera as a probe for adhesive ligands of lymph node high endothelial venules. J. Cell. Biol. 110: 2221-2229, 1990.