Class IV alcohol/retinol dehydrogenase localization in epidermal basal layer: Potential site of retinoic acid synthesis during skin development

Developmental Dynamics

Volumn 208, Issue 4, 1997, Pages 447-453

  Haselbeck, Robert J ^a   Ang, Hwee Luan ^a   Duester, Gregg ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

alcohol dehydrogenase; epidermis; keratinocyte terminal differentiation; retinoic acid; retinol dehydrogenase; skin; stratum basale

Indexed keywords

RETINOIC ACID; RETINOID X RECEPTOR; RETINOL DEHYDROGENASE;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; ENZYME LOCALIZATION; GROWTH REGULATION; KERATINOCYTE; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SKIN;

ALCOHOL DEHYDROGENASE; ALCOHOL OXIDOREDUCTASES; ANIMALS; EPIDERMIS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MICE; SKIN; TRETINOIN;

ANIMALIA;

EID: 15444339877     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0177(199704)208:4<447::AID-AJA1>3.0.CO;2-I     Document Type: Article

References (51)

1. Ang, H.L., Deltour, L., Hayamizu, T.F., Zgombic-Knight, M., and Duester, G. (1996a) Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression. J. Biol. Chem. 271:9526-9534.
2. Ang, H.L., Deltour, L., Zgombic-Knight, M., Wagner, M.A., and Duester, G. (1996b) Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis. Alcohol Clin. Exp. Res. 20:1050-1064.
3. Båvik, C.O., Peterson, P.A., and Eriksson, U. (1995) Retinol-binding protein mediates uptake of retinol to cultured human keratinocytes. Exp. Cell Res. 216:358-362.
4. Boleda, M.D., Saubi, N., Farrés, J., and Parés, X. (1993) Physiological substrates for rat alcohol dehydrogenase classes: Aldehydes of lipid peroxidation, omega-hydroxyfatty acids, and retinoids. Arch. Biochem. Biophys. 307:85-90.
5. Ceci, J.D., Lawther, R., Duester, G., Hatfield, G.W., Smith, M., O'Malley, M.P., and Felder, M.R. (1986) Androgen induction of alcohol dehydrogenase in mouse kidney: Studies with a cDNA probe confirmed by nucleotide sequence analysis. Gene 41:217-224.
6. Chai, X., Boerman, M.H.E.M., Zhai, Y., and Napoli, J.L. (1995) Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase. J. Biol. Chem. 270:3900-3904.
7. Connor, M.J. (1988) Oxidation of retinol to retinoic acid as a requirement for biological activity in mouse epidermis. Cancer Res. 48:7038-7040.
8. Connor, M.J., and Smit, M.H. (1987a) The formation of all-trans-retinoic acid from all-trans-retinol in hairless mouse skin. Biochem. Pharmacol. 36:919-924.
9. Connor, M.J., and Smit, M.H. (1987b) Terminal-group oxidation of retinol by mouse epidermis: Inhibition in vitro and in vivo. Biochem. J. 244:489-492.
10. Darmon, M. (1991) Retinoic acid in skin and epithelia. Semin. Dev. Biol. 2:219-228.
11. Deltour, L., Ang, H.L., and Duester, G. (1996) Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome. FASEB J. 10:1050-1057.
12. Deltour, L., Haselbeck, R.J., Ang, H.L., and Duester, G. (1997) Localization of class I and IV alcohol dehydrogenases in testis and epididymis: Potential retinol dehydrogenases for endogenous retinoic acid synthesis. Biol. Reprod. 56:102-109.
13. Dowling, J.E., and Wald, G. (1960) The biological function of vitamin A acid. Proc. Natl. Acad. Sci. USA 46:587-608.
14. Duester, G. (1996) Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis. Biochemistry 35:12221-12227.
15. Duester, G., Ang, H.L., Deltour, L., Foglio, M.H., Hayamizu, T.F., and Zgombic-Knight, M. (1995) Class I and class IV alcohol dehydrogenase (retinol dehydrogenase) gene expression in mouse embryos. Adv. Exp. Med. Biol. 372:301-313.
16. Edenberg, H.J., Zhang, K., Fong, K., Bosron, W.F., and Li, T.-K. (1985) Cloning and sequencing of cDNA encoding the complete mouse liver alcohol dehydrogenase. Proc. Natl. Acad. Sci. USA 82:2262-2266.
17. Elder, J.T., Fisher, G.J., Zhang, Q.-Y., Eisen, D., Krust, A., Kastner, P., Chambon, P., and Voorhees, J.J. (1991) Retinoic acid receptor gene expression in human skin. J. Invest. Dermatol. 96:425-433.
18. Fisher, G.J., and Voorhees, J.J. (1996) Molecular mechanisms of retinoid actions in skin. FASEB J. 10:1002-1013.
19. Fisher, G.J., Reddy, A.P., Datta, S.C., Kang, S., Yi, J.Y., Chambon, P., and Voorhees, J.J. (1995) All-trans retinoic acid induces cellular retinol-binding protein in human skin in vivo. J. Invest. Dermatol. 105:80-86.
20. Frazier, C.N., and Hu, C.K. (1931) Cutaneous lesions associated with a deficiency in vitamin A in man. Arch. Intern. Med. 48:507-514.
21. Holmes, R.S. (1978) Electrophoretic analyses of alcohol dehydrogenase, aldehyde dehydrogenase, aldehyde oxidase, sorbitol dehydrogenase and xanthine oxidase from mouse tissues. Comp. Biochem. Physiol. [B] 61:339-346.
22. Holmquist, B., and Vallee, B.L. (1991) Human liver class III alcohol and glutathione dependent formaldehyde dehydrogenase are the same enzyme. Biochem. Biophys. Res. Commun. 178:1371-1377.
23. Imakado, S., Bickenbach, J.R., Bundman, D.S., Rothnagel, J.A., Attar, P.S., Wang, X.-J., Walczak, V.R., Wisniewski, S., Pote, J., Gordon, J.S., Heyman, R.A., Evans, R.M., and Roop, D.R. (1995) Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. Genes Dev. 9:317-329.
24. Jörnvall, H., Danielsson, O., Hjelmqvist, L., Persson, B., and Shafqat, J. (1995) The alcohol dehydrogenase system. Adv. Exp. Med. Biol. 372:281-294.
25. Kang, S.W., Duell, E.A., Fisher, G.J., Datta, S.C., Wang, Z.Q., Reddy, A.P., Tavakkol, A., Yi, J.Y., Griffiths, C.E.M., Elder, J.T., and Voorhees, J.J. (1995) Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J. Invest. Dermatol. 105:549-556.
26. Kastner, P., Chambon, P., and Leid, M. (1994) Role of nuclear retinoic acid receptors in the regulation of gene expression. In: "Vitamin A in Health and Disease," Blomhoff, R. (ed). New York: Marcel Dekker, Inc., pp. 189-238.
27. Kaufman, M.H. (1992) "The Atlas of Mouse Development." San Diego: Academic Press, Inc.
28. Kedishvili, N.Y., Bosron, W.F., Stone, C.L., Hurley, T.D., Peggs, C.F., Thomasson, H.R., Popov, K.M., Carr, L.G., Edenberg, H.J., and Li, T.-K. (1995) Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes. J. Biol. Chem. 270:3625-3630.
29. Kim, C.-I., Leo, M.A., and Lieber, C.S. (1992) Retinol forms retinoic acid via retinal. Arch. Biochem. Biophys. 294:388-393.
30. Klein-Szanto, A., Martin, D., and Pine, A. (1980) Cutaneous manifestations in rats with advanced vitamin A deficiency. J. Cutan. Pathol. 7:260-270.
31. Koivusalo, M., Baumann, M., and Uotila, L. (1989) Evidence for the identity of glutathione-dependent formaldehyde dehydrogenase and class III alcohol dehydrogenase. FEBS Lett. 257:105-109.
32. Kurlandsky, S.B., Xiao, J.-H., Duell, E.A., Voorhees, J.J., and Fisher, G.J. (1994) Biological activity of all-trans retinol requires metabolic conversion to all-trans retinoic acid and is mediated through activation of nuclear retinoid receptors in human keratinocytes. J. Biol. Chem. 269:32768.
33. Kurlandsky, S.B., Duell, E.A., Kang, S., Voorhees, J.J., and Fisher, G.J. (1996) Auto-regulation of retinoic acid biosynthesis through regulation of retinol esterification in human keratinocytes. J. Biol. Chem. 271:15346-15352.
34. Leo, M.A., Kim, C., Lowe, N., and Lieber, C.S. (1989) Increased hepatic retinal dehydrogenase activity after phenobarbital and ethanol administration. Biochem. Pharmacol. 38:97-103.
35. Mangelsdorf, D.J., Umesono, K., and Evans, R.M. (1994) The retinoid receptors. In: "The Retinoids: Biology, Chemistry, and Medicine, 2nd Ed," Sporn, M.B., Roberts, A.B., and Goodman, D.S. (eds). New York: Raven Press, Ltd., pp. 319-349.
36. Mezey, E., and Holt, P.R. (1971) The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina. Exp. Mol. Pathol. 15:148-156.
37. Moreno, A., and Parés, X. (1991) Purification and characterization of a new alcohol dehydrogenase from human stomach. J. Biol. Chem. 266:1128-1133.
38. Napoli, J.L. (1986) Retinol metabolism in LLC-PK1 cells: Characterization of retinoic acid synthesis by an established mammalian cell line. J. Biol. Chem. 261:13592-13597.
39. Parés, X., Moreno, A., Cederlund, E., Höög, J.-O., and Jörnvall, J. (1990) Class IV mammalian alcohol dehydrogenase: Structural data of the rat stomach enzyme reveal a new class well separated from those already characterized. FEBS Lett. 277:115-118.
40. Randolph, R.K., and Simon, M. (1993) Characterization of retinol metabolism in cultured human epidermal keratinocytes. J. Biol. Chem. 268:9198-9205.
41. Saitou, M., Sugai, S., Tanaka, T., Shimouchi, K., Fuchs, E., Narumiya, S., and Kakizuka, A. (1995) Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature 374:159-162.
42. Saurat, J.H., Didierjean, L., Masgrau, E., Piletta, P.A., Jaconi, S., Chatellard-Gruaz, D., Gumowski, D., Masouyé, I., Salomon, D., and Siegenthaler, G. (1994) Topical retinaldehyde on human skin: Biologic effects and tolerance. J. Invest. Dermatol. 103:770-774.
43. Siegenthaler, G., Saurat, J.-H., and Ponec, M. (1990) Retinol and retinal metabolism. Relationship to the state of differentiation of cultured human keratinocytes. Biochem. J. 268:371-378.
44. Tavakkol, A., Griffiths, C.E.M., Keane, K.M., Palmer, R.D., and Voorhees, J.J. (1992) Cellular localization of mRNA for cellular retinoic acid-binding protein II and nuclear retinoic acid receptor-gamma1 in retinoic acid-treated human skin. J. Invest. Dermatol. 99:146-150.
45. Vallee, B.L., and Bazzone, T.J. (1983) Isozymes of human liver alcohol dehydrogenase. Curr. Top. Biol. Med. Res. 8:219-244.
46. Wilkinson, D.G., and Nieto, M.A. (1993) Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol. 225:361-373.
47. Wilson, J.G., Roth, C.B., and Warkany, J. (1953) An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am. J. Anat. 92:189-217.
48. Wolbach, S.B., and Howe, P.R. (1925) Tissue changes following deprivation of fat-soluble A vitamin. J. Exp. Med. 42:753-777.
49. Xiao, J.-H., Durand, B., Chambon, P., and Voorhees, J.J. (1995) Endogenous retinoic acid receptor (RAR)-retinoid X receptor (RXR) heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes. Binding of ligands to RAR only is sufficient for RAR-RXR heterodimers to confer ligand-dependent activation of hRARβ2/RARE (DR5). J. Biol. Chem. 270:3001-3011.
50. Yang, Z.-N., Davis, G.J., Hurley, T.D., Stone, C.L., Li, T.-K., and Bosron, W.F. (1994) Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction. Alcohol Clin. Exp. Res. 18:587-591.
51. Zgombic-Knight, M., Ang, H.L., Foglio, M.H., and Duester, G. (1995) Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family. J. Biol. Chem. 270:10868-10877.