Effects of temperature on intracellular sodium, pH and cellular energy status in RIF-1 tumor cells

NMR in Biomedicine

Volumn 17, Issue 1, 2004, Pages 33-42

  Babsky, Andriy ^a,c   Hekmatyar, S K ^a   Wehrli, Suzanne ^b   Nelson, David ^a   Bansal, Navin ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cellular energy status; Intracellular sodium; NTP; pH; RIF 1; Temperature

Indexed keywords

CELLS; ION EXCHANGE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH EFFECTS; TUMORS;

CELLULAR ENERGY; TUMOR CELLS;

BIOMEDICAL ENGINEERING;

5 (N ETHYL N ISOPROPYL)AMILORIDE; NUCLEOTIDE; PHOSPHATE; PHOSPHORUS 31; SODIUM; SODIUM 23; SODIUM PROTON EXCHANGE PROTEIN;

ACIDIFICATION; ANIMAL CELL; ARTICLE; BIOENERGY; CELL CULTURE; CELL ENERGY; CELL PH; CONTROLLED STUDY; ENERGY CONSUMPTION; ENERGY YIELD; FIBROSARCOMA; HEATING; ION EXCHANGE; IRRADIATION; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTON SODIUM EXCHANGE; RECTUM TEMPERATURE; SODIUM CELL LEVEL; TEMPERATURE DEPENDENCE; TISSUE PERFUSION; TUMOR CELL;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; ENERGY METABOLISM; FIBROSARCOMA; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; SODIUM; TEMPERATURE;

ANIMALIA;

EID: 1542725950     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/nbm.862     Document Type: Article

References (47)

1. 31P NMR spectroscopy, HPLC and cell survival analysis. Int. J. Hyperthermia 1997; 13: 69-82.
2. Amorino GP, Fox M. Heat-induced changes in intracellular sodium and membrane potential: lack of a role in cell killing and thermotolerance. Radiat. Res. 1996; 146: 283-292.
3. + antiport function and survival in mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 1996; 34: 623-634.
4. Skrandies S, Bremer B, Pilatus U, Mayer A, Neuhaus-Steinmetz U, Rensing L. Heat shock- and ethanol-induced ionic changes in c6 rat glioma cells determined by NMR and fluorescence spectroscopy. Brain Res. 1997; 746: 220-230.
5. Jayasundar R, Honess D, Hall LD, Bleehen NM. Simultaneous evaluation of the effects of RF hyperthermia on the intra- and extracellular tumor pH. Magn. Reson. Med. 2000; 43: 1-8.
6. Dave S, Vaupel P, Mueller-Kliesser P, Blendstrup K. Temperature distribution in peripheral s.c. tumors in rats. In: Hyperthermic Oncology, Overgaard J (ed.). Taylor and Francis: London, 1984; 503-506.
7. Vaupel P, Kallinowski F. Physiological effects of hyperthermia. Rec. Results Cancer Res. 1987; 104: 71-109.
8. Sheldon PW, Chu AM. The effect of anesthetics on the radio-sensitivity of a murine tumor. Radiat. Res. 1979; 79: 568-578.
9. Rockwell S, Loomis R. Effects of sodium pentobarbital on the radiation response of EMT6 cells in vitro and EMT6 tumors in vivo. Radiat. Res. 1980; 81: 292-302.
10. 31P nuclear magnetic resonance spectroscopy. Radiat. Res. 1988; 115: 361-372.
11. Pallavicini MG, Hill RP. Effect of tumor blood flow manipulations on radiation response. Int. J. Radiat. Oncol. Biol. Phys. 1983; 9: 1321-1325.
12. Jayasundar R, Hall LD, Bleehen NM. The effects of anesthesia and physical restraint on intra- and extracellular tumor pH, tumor temperature and bioenergetics in murine RIF-1 tumors. Magn. Reson. Imag. 1997; 15: 847-855.
13. Brown SL, Hunt JW, Hill RP. Differential thermal sensitivity of tumour and normal tissue microvascular response during hyperthermia. Int. J. Hyperthermia 1992; 8: 501-514.
14. Stryer L. Biochemistry, 4th edn. WH Freeman: New York, 1999; 181-206.
15. Dean J (ed.). Lange's Handbook of Chemistry, 13th edn. McGraw-Hill: New York, 1985.
16. Rahn H, Reeves RB, Howell BJ. Hydrogen ion regulation, temperature and evolution. Am. Rev. Resp. Dis. 1975; 112: 165-172.
17. - activities in Ehrlich ascites tumor cells. Biochim. Biophys. Acta. 1986; 860: 293-300.
18. + -ATPase. J. Biol. Chem. 1994; 269: 19659-19662.
19. Jorgensen PL, Hakansson KO, Karlish SJ. Structure and mechanism of Na, K-ATPase: functional sites and their interactions. A. Rev. Physiol. 2003; 65: 817-849.
20. Eddy AA. Sodium cotransport systems and the membrane potential difference. Ann. J. NY Acad. Sci. 1985; 456: 51-62.
21. i handling in the failing human heart. Cardiovasc. Res. 2003; 57: 874-886.
22. + -ATPase of Chinese hamster ovary cells. Radiat. Res. 1985; 102: 314-323.
23. + exchangers, NHE1 and NHE3, in transfected fibroblasts. J. Membr. Biol. 1997; 160: 183-192.
24. Anghileri LJ, Crone MC, Robert J. Intracellular ionic changes during hyperthermia of tumor cells in the presence of lanthanum. Neoplasma 1985; 32: 369-373.
25. + transport of V79 fibroblasts. J. Cell Physiol. 1990; 144: 216-221.
26. Osbakken M, Ivanics T, Zhang D, Mitra R, Blum H. Isolated cardiomyocytes in conjunction with NMR spectroscopy techniques to study metabolism and ion flux. J. Biol. Chem. 1992; 267: 15340-15347.
27. Lowry H, Rosenbrough NH, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265-275.
28. 2H NMR spectroscopy using water as an internal intensity reference. Magn. Reson. Med. 1992; 28: 105-121.
29. Kost GL. pH standardization for phosphorus-31 magnetic resonance heart spectroscopy at different temperatures. Magn. Reson. Med. 1990; 14: 496-506.
30. 31P-MRS measurement of extracellular pH of tumors using 3-aminopropylphosphonate. Am. J. Physiol. 1994; 267 (Cell Physiol. 36): C195-C203.
31. 23Na shift reagent for the in vivo rat liver. Biochemistry 1993; 32: 5638-5643.
32. Miyazaki N, Kurihara K, Nakano H, Shinohara K. Role of ATP in the sensitivity to heat and the induction of apoptosis in mammalian cells. Int. J. Hyperthermia 2002; 18: 316-331.
33. + ATPase activity in mouse lung fibroblasts and HeLa S3 cells during and after hyperthermia. Int. J. Hyperthermia 1986; 2: 51-59.
34. 2+ exchange in human epidermoid A431 cells. Am. J. Physiol. 1992; 263 (Cell Physiol. 32): C30-C38.
35. Lyons JC, Kim GE, Song CW. Modification of intracellular pH and thermosensitivity. Radiat. Res. 1992; 129: 79-87.
36. Lyons JC, Ross BD, Song CW. Enhancement of hyperthermia effect in vivo by amiloride and DIDS. Int. J. Radiat. Oncol. Biol. Phys. 1993; 25: 95-103.
37. Streffer C. Aspects of metabolic change after hyperthermia. Rec. Results Cancer Res. 1988; 107: 7-16.
38. Kleyman TR, Cragoe EJ Jr. Amiloride and its analogs as tools in the study of ion transport. J. Membr. Biol. 1988; 105: 1-21.
39. Mahnensmith RL, Aronson PS. The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes. Circul. Res. 1985; 56: 773-788.
40. Kim GE, Lyons JC, Song CW. Effects of amiloride on intracellular pH and thermosensitivity. Int. J. Radiat. Oncol. Biol. Phys. 1991; 20: 541-549.
41. Maidorn RP, Cragoe EJ Jr, Tannock IF. Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy. Br. J. Cancer 1993; 67: 297-303.
42. Boyer MJ, Tannock IF. Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions. Cancer Res. 1992; 52: 4441-4447.
43. Griffiths JR. Are cancer cells acidic? Br. J. Cancer 1991; 64: 425-427.
44. Stubbs M, Rodrigues L, Howe FA, Wang J, Jeong KS, Veech RL, Griffiths JR. Metabolic consequences of a reversed pH gradient in rat tumors. Cancer Res. 1994; 54: 4011-4016.
45. 1H NMR spectroscopy of tumors in vivo: untreated growth and response to chemotherapy. Ann. NY Acad. Sci. 1987; 508: 200-215.
46. 31P NMR spectroscopy, HPLC and cell survival analysis. Int. J. Hyperthermia. 1997; 13: 69-82.
47. Song CW, Kim GE, Lyons JC, Makepeace CM, Griffin RJ, Rao GH, Cragoe EJ Jr. Thermosensitization by increasing intracellular acidity with amiloride and its analogs. Int. J. Radiat. Oncol. Biol. Phys. 1994; 30: 1161-1169.