Fourier Transformed Infrared Spectroscopic Investigation of Protein Conformation in Spray-Dried Protein/Trehalose Powders

Biopolymers

Volumn 73, Issue 4, 2004, Pages 524-531

  French, Donna L ^a   Arakawa, Tsutomu ^b   Li, Tiansheng ^a  

^a AMGEN INC   (United States)

^b ALLIANCE PROTEIN LABORATORIES   (United States)

Author keywords

Fourier transform IR spectroscopy; Recombinant consensus interferon spray dried powder; Recombinant human granolucyte colony stimulating factor; Relative humidity; Trehalose

Indexed keywords

ATMOSPHERIC HUMIDITY; COMPOSITION; CONFORMATIONS; DEGRADATION; DRYING; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HYDRATION; POWDERS; SUGARS;

LYOPHILIZATION; SPRAY DRYING;

PROTEINS;

DEUTERIUM; HYDROGEN; SUGAR; TREHALOSE; ALPHA INTERFERON; PROTEIN; PROTON; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT PROTEIN; SOLVENT;

ALPHA HELIX; ARTICLE; BETA SHEET; CHEMICAL COMPOSITION; CONFORMATIONAL TRANSITION; FREEZE DRYING; HUMIDITY; HYDRATION; INFRARED SPECTROSCOPY; POWDER; PROTEIN CONFORMATION; PROTEIN DEGRADATION; SPRAY DRYING; CHEMISTRY; DESICCATION; ESCHERICHIA COLI; GENETICS; HUMAN; METABOLISM; NEBULIZER; PROTEIN SECONDARY STRUCTURE; SYNTHESIS;

DESICCATION; ESCHERICHIA COLI; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; HUMANS; HUMIDITY; INTERFERON-ALPHA; NEBULIZERS AND VAPORIZERS; POWDERS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEINS; PROTONS; RECOMBINANT PROTEINS; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TREHALOSE;

EID: 1542724789     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10558     Document Type: Article

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