Role of B Cells and Macrophages in Microvascular Disease after Heart Transplantation

Thoracic and Cardiovascular Surgeon

Volumn 52, Issue 1, 2004, Pages 16-22

  Hiemann, Nicola E ^a   Meyer, R ^a   Hummel, M ^a   Wellnhofer, E ^a   Thomann, S ^a   Hetzer, R ^a  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Complications; Graft vessel disease; Heart transplantation; Histology; Smooth muscle cells

Indexed keywords

ARTICLE; B LYMPHOCYTE; BLOOD VESSEL REACTIVITY; CELL SWELLING; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPHOCYTE FUNCTION; MACROPHAGE FUNCTION; MAJOR CLINICAL STUDY; MALE; MICROANGIOPATHY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SMOOTH MUSCLE FIBER; T LYMPHOCYTE; THICKNESS; TISSUE SECTION;

ADULT; B-LYMPHOCYTES; BIOLOGICAL MARKERS; BIOPSY; CARDIOMYOPATHY, DILATED; CORONARY ARTERIOSCLEROSIS; ENDOTHELIAL CELLS; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MIDDLE AGED; MYOCARDIUM; SEVERITY OF ILLNESS INDEX; STATISTICS; T-LYMPHOCYTES; TREATMENT OUTCOME; VASCULAR DISEASES;

EID: 1542724784     PISSN: 01716425     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-815799     Document Type: Article

References (34)

1. Deng MC, Plenz G, Erren M et al. Transplant vasculopathy: a model for coronary artery disease? Herz 2000; 25: 95-99
2. Billingham ME. Cardiac transplant atherosclerosis. Transplant Proc 1987; 19: 19-25
3. Hiemann NE, Musci M, Wellnhofer E, Meyer R, Hetzer R. Light microscopic biopsy findings after heart transplantation and possible links to development of graft vessel disease. Transplant Proc 1999; 31: 149-151
4. Hiemann NE, Meyer R, Wellnhofer E, Klimek WJ, Bocksch W, Hetzer R. Correlation of angiographic and immunohistochemical findings in graft vessel disease after heart transplantation. Transplant Proc 2001; 33: 1586-1590
5. Ardehali A, Laks H, Drinkwater DC et al. Expression of major histocompatibility antigens and vascular adhesion molecules on human cardiac allografts preserved in University of Wisconsin solution. J Heart Lung Transplant 1993; 12: 1044-1051
6. Hosenpud JD. Coronary artery disease after heart transplantation and its relation to cytomegalovirus. Am Heart J 1999; 138: S469-S472
7. Gao HZ, Hunt SA, Alderman EL, Liang D, Yeung AC, Schroeder JS. Relation of donor age and preexisting coronary artery disease on angiography and intracoronary ultrasound to later development of accelerated allograft coronary artery disease. J Am Coll Cardiol 1997; 29: 623-629
8. Uretsky BF, Murali S, Reddy PS et al. Development of coronary artery disease in cardiac transplant patients receiving immunosuppressive therapy with cyclosporine and prednisone. Circulation 1987; 76: 827-834
9. Winters GL, Kendall TJ, Radio SJ et al. Posttransplant obesity and hyperlipidemia: major predictors of severity of coronary arteriopathy in failed human heart allografts. J Heart Transplant 1990; 9: 364-371
10. Billingham ME, Cary NR, Hammond ME et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant 1990; 9: 587-593
11. Joshi A, Masek MA, Brown BW, Weiss LM, Billingham ME. "Quilty" revisited: a 10-year perspective. Hum Pathol 1995; 26: 547-557
12. Naish SJ. Handbuch II immunhistochemischer Färbemethoden. Via Real, CA, USA: Dako Corporation, 1989
13. Akbar AN, Terry L, Timms A, Beverley PC, Janossy G. Loss of CD45 R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol 1988; 140: 2171-2178
14. Poppema S, Lai R, Visser L. Monoclonal antibody OPD4 is reactive with CD45RO, but differs from UCHL1 by the absence of monocyte reactivity. Am J Pathol 1991; 139: 725-729
15. Pulford KAF, Rigney EM, Micklem KJ et al. KPI: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol 1989; 42: 414-421
16. Hiemann NE, Meyer R, Wellnhofer E, Hetzer R. Correlation of vascular reaction in endomyocardial biopsies with micro- and macrovascular graft vessel disease after heart transplantation. Graft 2002; 5: 173-178
17. Mader AM, Alves MT, Kawakami E, Patricio FR. [Reflux esophagitis in children: histological and morphometric study]. Arq Gastroenterol 2002; 39: 126-131
18. Rickenbacher PR, Pinto FJ, Lewis NP et al. Correlation of donor characteristics with transplant coronary artery disease as assessed by intracoronary ultrasound and coronary angiography. Am J Cardiol 1995; 76: 340-345
19. Keck BM, Bennett LE, Rosendale J, Daily OP, Novick RJ, Hosenpud JD. Worldwide thoracic organ transplantation: a report from the UNOS/ISHLT International Registry for Thoracic Organ Transplantation. Clin Transpl 1999; 19: 35-49
20. Gullestad L, Ross H, Myers J et al. Importance of decreased heart rate in predicting transplant coronary artery disease. Clin Transplant 1997; 11: 628-632
21. Olivari MT, Homans DC, Wilson RF, Kubo SH, Ring WS. Coronary artery disease in cardiac transplant patients receiving triple-drug immunosuppressive therapy. Circulation 1989; 80: 111-115
22. Baandrup U, Olsen EG. Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. I: Morphological and morphometric aspects. Br Heart J 1981; 45: 475-486
23. Kavantzas NG, Lazaris AC, Agapitos EV, Nanas J, Davaris PS. Histological assessment of apoptotic cell death in cardiomyopathies. Pathology 2000; 32: 176-180
24. Tracy RE. Medial thickenings of coronary artery and the aging risk factor for atherosclerosis. Atherosclerosis 2001; 155: 337-346
25. Baughman RP, Doers J, Lower EE, Buchsbaum J. Isolation of functionally active pleural macrophages. J Clin Lab Immunol 1989; 30: 147-151
26. Goddard MJ, Dunning J, Horsley J, Atkinson C, Pino-Chavez G, Wallwork J. Histopathology of cardiac xenograft rejection in the pig-to-baboon model. J Heart Lung Transplant 2002; 21: 474-484
27. Fyfe A, Daly P, Galligan L, Pirc L, Feindel C, Cardella C. Coronary sinus sampling of cytokines after heart transplantation: evidence for macrophage activation and interleukin-4 production within the graft. J Am Coll Cardiol 1993; 21: 171-176
28. Holzinger C, Zuckermann A, Reinwald C et al. Are T cells from healthy heart really only passengers? Characterization of cardiac tissue T cells. Immunol Lett 1996; 53: 63-67
29. Gopal S, Narasimhan U, Day JD et al. The quilty lesion enigma: focal apoptosis/necrosis and lymphocyte subsets in human cardiac allografts. Pathol Int 1998; 48: 191-198
30. Radio SJ, McManus BM, Winters GL et al. Preferential endocardial residence of B-cells in the "Quilty effect" of human heart allografts: immunohistochemical distinction from rejection. Mod Pathol 1991; 4: 654-660
31. Clausell N, Butany J, Molossi S et al. Abnormalities in intramyocardial arteries detected in cardiac transplant biopsy specimens and lack of correlation with abnormal intracoronary ultrasound or endothelial dysfunction in large epicardial coronary arteries. J Am Coll Cardiol 1995; 26: 110-119
32. Hutchinson IV. Cardiac allograft vasculopathy - the cellular attack. Z Kardiol 2000; 89: IX/16-20
33. Hiemann NE, Meyer R, Musci M, Wellnhofer E, Hetzer R. Prädiktiver Wert des frühen Endothelzellschadens für die Entwicklung einer Transplantatvaskulopathie nach Herztransplantation. Z Kardiologie 1998; 87 (Suppl 5): 89
34. Knight RJ, Dikman S, Liu H, Martinelli GP. Cold ischemic injury accelerates the progression to chronic rejection in a rat cardiac allograft model. Transplantation 1997; 64: 1102-1107