A freeze-dried fibrin disc as a biodegradable drug release matrix

Biologicals

Volumn 32, Issue 1, 2004, Pages 49-55

  Kumar, T R Santhosh ^a   Bai, Mary Vasantha ^a   Krishnan, Lissy K ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

Antibiotics; Drug release; Fibrin disc; Haemostatic; Wound care

Indexed keywords

ANTIBIOTIC AGENT; ANTIBODY; BUFFER; FIBRIN; FIBRIN DEGRADATION PRODUCT; FIBRINOGEN; PHOSPHATE; SODIUM CHLORIDE; TETRACYCLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; FIBRIN CLOT; FIBRINOLYSIS; FREEZE DRYING; HEMOSTASIS; HUMAN; KINETICS; MICROBIAL GROWTH; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOCOMPATIBLE MATERIALS; DRUG DELIVERY SYSTEMS; FIBRIN; FREEZE DRYING; HUMANS; KINETICS; MICE; MICROSCOPY, ELECTRON, SCANNING; PHARMACEUTICAL PREPARATIONS; SERUM; TIME FACTORS; WOUND HEALING;

EID: 1542722940     PISSN: 10451056     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biologicals.2003.11.002     Document Type: Article

References (13)

1. Wahlig H., Dingeldein E., Bergmann R., Reuss K. The release of gentamycin from polymethylmethacrylate beads: an experimental and pharmacokinetic study. J Bone Joint Surg Br. 60:1978;270-275.
2. Wahlig H., Dingeldein E. Antibiotics and bone cements: experimental and clinical long-term observations. Acta Orthop Scand. 51:1980;49-56.
3. Becker P.L., Smith R.A., Williams R.S., Ovtkowsky J.P. Comparison of antibiotic release from polymethyl methacrylate beads and spong collagen. J Orthop Res. 12:1994;737-741.
4. Watanabe G., Haverich A., Spier R. Surgical treatment of active infective endocarditis with paravalvular involvement. J Thorac Cardiovasc Surg. 107:1994;171-177.
5. McKeller S.H.M., Bryce D.A., Marks J.D., Cowley C.G., Classen D.C., Gardner S.C., et al. Treatment of infected left ventricular assist device using antibiotic impregnated beads. Ann Thorac Surg. 67:1999;554-555.
6. Price J.S., Tencer A.F., Arm D.M., Bohach G.A. Controlled release of antibiotics from coated orthopaedic implants. J Biomed Mater Res. 30:1996;281-286.
7. Wachol-Drewek Z., Pfeiffer M., Scholl E. Comparative investigation of drug delivery of collagen implants saturated in antibiotic solutions and sponge containing gentamycin. Biomaterials. 17:1996;1733-1738.
8. Greco F., de Palma L., Spagnolo N., Rossi A., Specchia N., Gigante A. Fibrin antibiotic mixtures: an in vitro study assessing the possibility of using a biologic carrier for local drug delivery. J Biomed Mater Res. 25:(1):1991;39-51.
9. Schlag H.R.G., Hirschl G.S.A., Seelich T. In vitro properties of mixtures of fibrin seal and antibiotics. Biomaterials. 4:1983;29-32.
10. Saltz R., Sierra D., Feldman D., Bartczak-Saltz M., Dimick A., Vasconez L.O. Experimental and clinical applications of fibrin glue. Plast Reconstr Surg. 88:(6):1991;1005-1011.
11. Tsourvaka S., Hatzigrigoris P., Tsibinos A., Kannellakopoulou K., Giamarellou H., Dounis E. Pharmacokinetic study of fibrin clot-ciprofloxacin complex: an in vitro and in vivo experimental investigation. Arch Orthop Trauma Surg. 114:1995;295-297.
12. Harland R., Dubernet C., Benoit J., Peppas N.A. A model of dissolution controlled, diffusional drug release from nonswellable polymeric microspheres. J Control Release. 7:1988;207-213.
13. Kumar T.R.S., Krishnan L.K. Endothelial cell growth factor (ECGF) enmeshed fibrin matrix enhances proliferation of EC in vitro. Biomaterials. 22:2001;2769-2776.