On the estimation of the binomial probability in multistage clinical trials

Statistics in Medicine

Volumn 23, Issue 6, 2004, Pages 881-896

  Jung, Sin Ho ^a   Kim, Kyung Mann ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Confidence interval; Maximum likelihood estimator; Phase II clinical trial; Stochastic ordering; Uniformly minimum variance unbiased estimator

Indexed keywords

ANTINEOPLASTIC AGENT;

ARTICLE; BINOMIAL DISTRIBUTION; CANCER; CANCER PATIENT; CANCER STAGING; CLINICAL STUDY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DRUG EFFICACY; DRUG INFORMATION; DRUG SAFETY; DRUG SCREENING; HUMAN; INTERMETHOD COMPARISON; MAXIMUM LIKELIHOOD METHOD; PHASE 2 CLINICAL TRIAL; PROBABILITY; SAMPLING; SEQUENTIAL ANALYSIS; STATISTICAL ANALYSIS; VARIANCE;

CLINICAL TRIALS, PHASE II; CONFIDENCE INTERVALS; DRUG EVALUATION; HUMANS; LIKELIHOOD FUNCTIONS; NEOPLASMS; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; RESEARCH DESIGN; STATISTICS; STOCHASTIC PROCESSES;

EID: 1542715722     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1653     Document Type: Article

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