Do SSRIs cause gastrointestinal bleeding?

Drug and Therapeutics Bulletin

Volumn 42, Issue 3, 2004, Pages 17-18

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMFEBUTAMONE; AMITRIPTYLINE; AMOXAPINE; ANTICOAGULANT AGENT; ANTIDEPRESSANT AGENT; CLOMIPRAMINE; CORTICOSTEROID; DESIPRAMINE; DOSULEPIN; DOXEPIN; FLUOXETINE; FLUVOXAMINE; IMIPRAMINE; LOFEPRAMINE; MAPROTILINE; MIANSERIN; NEFAZODONE; NONSTEROID ANTIINFLAMMATORY AGENT; NORTRIPTYLINE; PAROXETINE; PROTRIPTYLINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRAZODONE; TRIMIPRAMINE; VENLAFAXINE;

BLEEDING DISORDER; BLEEDING TIME; BRAIN HEMORRHAGE; DISEASE PREDISPOSITION; DRUG MECHANISM; DRUG USE; EPISTAXIS; GASTROINTESTINAL HEMORRHAGE; HUMAN; INTRAOCULAR HEMORRHAGE; MENORRHAGIA; RECTUM HEMORRHAGE; REVIEW; RISK ASSESSMENT; SEROTONIN RELEASE; SEROTONIN UPTAKE; SKIN BRUISING; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; UPPER GASTROINTESTINAL BLEEDING;

EID: 1542711247     PISSN: 00126543     EISSN: None     Source Type: Journal    
DOI: 10.1136/dtb.2004.42317     Document Type: Review

References (22)

1. Vanhoutte PM. Serotonin, hypertension and vascular disease. Neth J Med 1991; 38: 35-42.
2. Serebruany VL et al. Platelet inhibition by sertraline and N-desmethylsertraline: A possible missing link between depression, coronary events, and mortality benefits of selective serotonin reuptake inhibitors. Pharmacol Res 2001; 43: 453-61.
3. Layton D et al. Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England. Eur J Clin Pharmacol 2001; 57: 167-76.
4. Humphries JE et al. Fluoxetine and the bleeding time. Arch Pathol Lab Med 1990; 114: 727-8.
5. Yaryura-Tobias JA et al. Fluoxetine and bleeding in obsessive-compulsive disorder. Am J Psychiatry 1991; 148: 949.
6. Aranth J, Lindberg C. Bleeding, a side effect of fluoxetine. Am J Psychiatry 1992; 149: 412.
7. Gunzberger DW, Martinez D. Adverse vascular effects associated with fluoxetine. Am J Psychiatry 1992; 149: 1751.
8. Ottervanger JP et al. Risk of hemorrhage with the use of fluoxetine (Prozac) or fluvoxamine (Fevarin) Ned Tijdschr Geneeskd 1993; 137; 259-61.
9. Pai VB, Kelly MW. Bruising associated with the use of fluoxetine. Ann Pharmacother 1996; 30: 786-8.
10. Nelva A et al. Hemorrhagic syndromes related to selective seratonin reuptake inhibitor (SSRI) antidepressants. Seven case reports and review of the literature. Rev Med Interne 2000; 21: 152-60.
11. Lake MB et al. Bleeding and selective serotonin reuptake inhibitors in childhood and adolescence. J Child Adolesc Psychopharmacol 2000; 10: 35-8.
12. Cipralex 10 and 20mg film-coated tablets. Summary of product characteristics, Denmark. H. Lundbeck A/S, June 2002.
13. Cipramil tablets. Summary of product characteristics, UK. Lundbeck Limited, April 2003.
14. Faverin, Summary of product characteristics, UK. Solvey Healthcare Limited, July 2002.
15. Lustral. Summary of product characteristics, UK. Pfizer Limited, December 2002.
16. Prozac. Summary of product characteristics, UK. Eli Lilly and Company Limited, November 2000.
17. Seroxat tablets 20mg, 30mg, liquid 20mg/10ml. Summary of product characteristics, UK. SmithKline Beecham plc, June 2003.
18. Blatchford M, Macdonald L. Deprivation maybe a confounding variable [online]. Available: http://bmj.bmjjournals.com/cgi/eletters/319/7217/1106#5612 [Accessed 5 February 2004].
19. Sanders J. Antidepressants and upper gastrointestinal bleeds - a causative link?[online]. Available http://bmj.bmjjournals.com/cgi/eletters/319/7217/1106#6856 [Accessed 5 February 2004].
20. de Abajo FJ et al. Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: Population based case-control study. BMJ 1999; 319: 1106-9.
21. van Walraven C et al. Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study[online]. Available: http://bmj.bmjjournals.com/cgi/reprint/323/7314/655.pdf [Accessed 5 February 2004].
22. Dalton SO et al. Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: A population-based cohort study. Arch Intern Med 2003; 163: 59-64.