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Volumn 8, Issue 3, 1996, Pages 165-171

Efficient inhibition of HIV-1 aspartic protease by synthetic, computer designed peptide mimetics

Author keywords

Aspartic protease; Drug design; HIV 1; Peptides, chemical synthesis

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 1542706596     PISSN: 11204826     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (2)

References (14)
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  • 3
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    • Protease uninhibited
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    • Richman, D.D.1
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    • Design of tight-binding human immunodeficiency virus Type 1 protease inhibitors
    • Vacca JP. Design of tight-binding human immunodeficiency virus Type 1 protease inhibitors. Methods Enzymol 1994; 241:311-34.
    • (1994) Methods Enzymol , vol.241 , pp. 311-334
    • Vacca, J.P.1
  • 5
    • 0024344021 scopus 로고
    • Structure of a complex of synthetic HIV-1 protease with a structure-based inhibitor at 2.3Å
    • Miller M, Schneider J, Sarhyanarayana BK, Toth MV, Marshall GR, Clawson L et al. Structure of a complex of synthetic HIV-1 protease with a structure-based inhibitor at 2.3Å. Science 1989;246:1149-52.
    • (1989) Science , vol.246 , pp. 1149-1152
    • Miller, M.1    Schneider, J.2    Sarhyanarayana, B.K.3    Toth, M.V.4    Marshall, G.R.5    Clawson, L.6
  • 8
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    • Continuum models of environmental effects on molecular structure and mechanisms in chemistry and biology
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    • Miertus, S.1    Frecer, V.2
  • 9
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    • Evaluation of complexation energies between the aspartic protease of HIV-1 and its hexapeptide inhibitors, including the effect of solvation
    • Miertus S. Evaluation of complexation energies between the aspartic protease of HIV-1 and its hexapeptide inhibitors, including the effect of solvation. Bioorg and Med Chem Letters 1993;3:2105-12.
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    • Miertus, S.1
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    • An efficient synthesis of optically active α-(t-butoxycarbonylamino)-aldehydes from α-amino acids
    • Fehrentz, JA, Castro B. An efficient synthesis of optically active α-(t-butoxycarbonylamino)-aldehydes from α-amino acids. Synthesis 1983;676-8.
    • (1983) Synthesis , pp. 676-678
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  • 12
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    • Use of steady state kinetic methods to elucidate the kinetic and chemical mechanisms of retroviral proteases
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    • (1994) Meth Enzymol , vol.241 , pp. 127-156
    • Meek, T.D.1    Rodriguez, E.J.2    Angeles, T.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.