Reversal by L- And D-Enantiomers of NG-Nitro-Arginine of Endotoxin-Induced Hypotension and Vascular Hyporesponsiveness

Journal of Cardiovascular Pharmacology

Volumn 28, Issue 1, 1996, Pages 75-81

  Cheng, Xing ^a   Wang, Yong Xiang ^a   Pang, Catherine C Y ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Arginine; Blood pressure; Derived relaxing factor (EDRF); Endothelium; Endotoxemia; Lipopolysaccharide (LPS); Nitric oxide synthase

Indexed keywords

ENDOTOXIN; LIPOPOLYSACCHARIDE; N(G) NITROARGININE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG INDUCED DISEASE; ENANTIOMER; ENDOTOXEMIA; ENZYME INHIBITION; HYPOTENSION; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE ACTIVATION; VASCULAR RESISTANCE;

ANIMALS; ESCHERICHIA COLI; HEMODYNAMIC PROCESSES; HYPOTENSION; LIPOPOLYSACCHARIDES; NITROARGININE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; TIME FACTORS;

EID: 1542703940     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199607000-00012     Document Type: Article

References (40)

1. Suffredini AF, From RE, Parker MM, et al. The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 1989;321:280-7.
2. Parrillo MM, Parker MM, Natanson C, et al. Septic shock in humans: advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 1991; 113:227-42.
3. Morrison DC, Ulevitch RJ. The effects of bacterial endotoxins on host mediated systems. Am J Pathol 1979;93:526-617.
4. Hewett JA, Roth RA. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides. Pharmacol Rev 1993; 45:382-411.
5. G-monomethyl-L-arginine. J Cardiovasc Pharmacol 1992;20:(suppl 12):S132-4.
6. Liu S, Adcock IM, Oild RW, Barnes PJ, Evans TW. Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA. Biochem Biophys Res Commun 1993;196:1208-13.
7. Stoclet JC, Fleming I, Gray G, et al. Nitric oxide and endotoxemia. Circulation 1993;87(suppl):77-80.
8. Szabo C, Mitchell JA, Thiemermann C, Vane JR. Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 1993;108:786-92.
9. Thiemermann C, Vane JR. Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur J Pharmacol 1990; 182:591-5.
10. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun 1990;172:1132-8.
11. Gray GA, Schott C, Julou-Schaeffer G, Fleming I, Parratt JR, Stoclet JC. The effect of inhibitors of the L-arginine/ nitric oxide pathway on endotoxin-induced loss of vascular responsiveness in anaesthetized rats. Br J Pharmacol 1991;103:1218-24.
12. Petros A, Bennett D, Vallance P. Effect of nitric oxide on hypotension in patients with septic shock. Lancet 1991;338: 1557-8.
13. G-nitro-L-arginine administration on the hemodynamics and plasma hormone levels during endotoxin shock in dogs. Nippon Naibunpi Gakkai Zasshi 1993;69:135-48.
14. Landin L, Lorente JA, Renes E, Canas P, Jorge P, Liste D. Inhibition of oxide synthesis improves the vasoconstrictive effect of noradrenaline in sepsis. Chest 1994;106:250-6.
15. Schott CA, Gray GA, Stoclet JC. Dependence of endotoxin-induced vascular hyporeactivity on extracellular L-arginine. Br J Pharmacol 1993;108:38-43.
16. Meyer J, Lentz CW, Stothert CJ, Traber LD, Herndon D, Traber D. Effects of nitric oxide synthesis inhibition in hyperdynamic endotoxemia. Crit Care Med 1994;22:306-12.
17. Fleming I, Gray GA, Julou-Schaeffer G, Parratt JR, Stoclet JC. Incubation with endotoxin activates the L-arginine pathway in vascular tissue. Biochem Biophys Res Commun 1990; 171:562-8.
18. Fleming I, Julou-Schaeffer G, Gray GA, Parratt JR, Stoclet JC. Evidence that an L-arginine/nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin. Br J Pharmacol 1991;103:1047-52.
19. Fleming I, Gray GA, Stoclet JC. Influence of endothelium on induction of the L-arginine-nitric oxide pathway in rat aortas. Am J Physiol 1993;264(4 Pt 2):H1200-7.
20. Ueno M, Lee TJ. Endotoxin decreases the contractile responses of the porcine basilar artery to vasoactive substances. J Cereb Blood Flow Metab 1993;13:712-9.
21. G-nitro-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem Biophys Res Commun 1994;199:147-54.
22. Julou-Schaeffer G, Gray GA, Fleming I, Schott C, Parratt JR, Stoclet JC. Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am J Physiol 1990;259(4 Pt 2):H1038-43.
23. Griffiths MJ, Messent M, Macallister RJ, Evans TW. Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol 1993;110:963-8.
24. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-42.
25. G-nitro-arginine on endothelium-dependent relaxation of rat aorta. J Pharmacol Exp Ther 1993;265:112-9.
26. G-nitro-arginine in conscious rats are antagonized by L- but not D-Arginine. Eur J Pharmacol 1991;200:77-81.
27. G-Nitro-L-arginine contracts vascular smooth muscle by an endothelium-independent mechanism. J Cardiovasc Pharmacol 1994;24:59-63.
28. Szabo C, Wu CC, Gross SS, Thiemermann C, Vane JR. Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo. Eur J Pharmacol 1993;250:157-60.
29. Szabo C, Wu CC, Mitchell JA, Gross SS, Thiemermann C, Vane JR. Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide. Circ Res 1993;73:991-9.
30. G-methylarginine. Biochem Biophys Res Commun 1990;170:96-103.
31. Gross SS, Jaffe EA, Levi R, Kibourn RG. Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages. Biochem Biophys Res Commun 1991;178:823-9.
32. G-nitro-L-arginine in pentobarbital-anesthetized rats. Life Sci 1990;47:2217-24.
33. G-nitro-L-arginine by halothane. J Cardiovasc Pharmacol 1993;22:571-8.
34. Mulder MF, Van-Lambalgen AA, Huisman E, Visser JJ, Van-den-Bos GC, Thijs LG. Protective role of NO in the regional hemodynamic changes during acute endotoxemia in rats. Am J Physiol 1994;266(4 Pt 2):H1558-64.
35. Nava E, Palmer RM, Moncada S. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? [Comments]. Lancet 1991;338(8782-3):1555-7.
36. Preiser JC, Zhang H, Wachel D, Boeynaems JM, Buurman W, Vincent JL. Is endotoxin-induced hypotension related to nitric oxide formation? Eur Surg Res 1994;26:10-8.
37. G-Monomethyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock. Biochem Biophys Res Commun 1991;178:1135-40.
38. Petros A, Lamb G, Leone A, Moncada S, Bennett D, Vallance P. Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res 1994;28:34-9.
39. Wright CE, Rees DD, Moncada S. Protective and pathological roles of nitric oxide in endotoxin shock [Comments]. Cardiovasc Res 1992;26:48-57.
40. Pastor C, Teisseire B, Vicaut E, Payen D. Effects of L-arginine and L-nitro-arginine treatment on blood pressure and cardiac output in a rabbit endotoxin shock model. Crit Care Med 1994;22:465-9.