Description of new mutations in the rpoB gene in rifampicin-resistant Neisseria meningitidis selected in vitro in a stepwise manner

Journal of Medical Microbiology

Volumn 52, Issue 12, 2003, Pages 1077-1081

  Nolte, Oliver ^a   Müller, Matthias ^a   Reitz, Stephan ^a   Ledig, Sandra ^a   Ehrhard, Ingrid ^b   Sonntag, Hans Günther ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Landesuntersuchungsanstalt G   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; RIFAMPICIN; DNA DIRECTED RNA POLYMERASE; RNA POLYMERASE BETA SUBUNIT; TUBERCULOSTATIC AGENT;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CONTROLLED STUDY; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA POLYMERASE BETA SUBUNIT GENE; SEQUENCE ANALYSIS; BACTERIUM TRANSFORMATION; DRUG EFFECT; GENETICS; MUTATION;

ANTIBIOTICS, ANTITUBERCULAR; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, BACTERIAL; MUTATION; NEISSERIA MENINGITIDIS; RIFAMPIN; TRANSFORMATION, BACTERIAL;

EID: 1542644976     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.05371-0     Document Type: Article

References (12)

1. Abadi, F. J. R., Carter, P. E., Cash, P. & Pennington, T. H. (1996). Rifampin resistance in Neisseria meningitidis due to alterations in membrane permeability. Antimicrob Agents Chemother 40, 646-651.
2. Aubry-Damon, H., Soussy, C.-J. & Courvalin, P. (1998). Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 42, 2590-2594.
3. Carter, P. E., Abadi, F. J. R., Yakubu, D. E. & Pennington, T. H. (1994). Molecular characterization of rifampin-resistant Neisseria meningitidis. Antimicrob Agents Chemother 38, 1256-1261.
4. Goodman, S. D. & Scocca, J. J. (1988). Identification and arrangement of the DNA sequence recognized in specific transformation of Neisseria gonorrhoeae. Proc Natl Acad Sci U S A 85, 6982-6986.
5. Goodman, S. D. & Scocca, J. J. (1991). Factors influencing the specific interaction of Neisseria gonorrhoeae with transforming DNA. J Bacteriol 173, 5921-5923.
6. Hagman, K. E., Pan, W., Spratt, B. G., Balthazar, J. T., Judd, R. C. & Shafer, W. M. (1995). Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 141, 611-622.
7. Jin, D. J. & Gross, C. A. (1988). Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance. J Mol Biol 202, 45-58.
8. Nolte, O. (1997). Rifampicin resistance in Neisseria meningitidis: evidence from a study of sibling strains, description of new mutations and notes on population genetics. J Antimicrob Chemother 39, 747-755.
9. Pan, W. & Spratt B. G. (1994). Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol Microbiol 11, 769-775.
10. Stefanelli, P., Fazio, C., La Rosa, G., Marianelli, C., Muscillo, M. & Mastrantonio, P. (2001). Rifampicin-resistant meningococci causing invasive disease: detection of point mutations in the rpoB gene and molecular characterization of the strains. J Antimicrob Chemother 47, 219-222.
11. Telenti, A., Imboden, P., Marchesi, F., Lowrie, D., Cole, S., Colston, M. J., Matter, L., Schopfer, K. & Bodmer, T. (1993). Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. Lancet 341, 647-650.
12. van der Ley, P. & Poolman, J. T. (1992). Construction of a multivalent meningococcal vaccine strain based on the class 1 outer membrane protein. Infect Immun 60, 3156-3161.