Estrogen receptors, progesterone receptors, and cell proliferation in human breast cancer

Breast Cancer Research and Treatment

Volumn 37, Issue 3, 1996, Pages 217-228

  Fanelli, Mariel A ^a   Vargas Roig, Laura M ^a   Gago, Francisco E ^b   Tello, Olga ^b   De Angelis, Rodolfo Lucero ^b   Ciocca, Daniel R ^a  

^a Laboratorio de Reproduccion y Lactancia Mendoza   (Argentina)

^b Children's Hospital of Mendoza   (Argentina)

Author keywords

AgNORs; Breast cancer; Cell proliferation; Estrogen receptor; PCNA; Progesterone receptor

Indexed keywords

CYCLINE; ESTROGEN; ESTROGEN RECEPTOR; MONOCLONAL ANTIBODY; PROGESTERONE; PROGESTERONE RECEPTOR;

ADULT; AGED; ARTICLE; BREAST BIOPSY; BREAST CANCER; BREAST EPITHELIUM; CELL PROLIFERATION; CHROMOSOME NOR; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SILVER STAINING; TARGET ORGAN; TUMOR BIOPSY;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CELL DIVISION; FEMALE; HUMANS; MIDDLE AGED; NUCLEOLUS ORGANIZER REGION; PROLIFERATING CELL NUCLEAR ANTIGEN; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE;

EID: 1542636227     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01806503     Document Type: Article

References (59)

1. Ciocca DR: Tumores hormonodependientes. Conceptos actuales. Medicina (Bs As) 48: 87-94, 1988
2. Going JJ, Anderson TJ, Battersby S, MacIntyre CCA: Proliferative and secretory activity in human breast during natural and artificial menstrual cycles. Am J Pathol 130: 193-203, 1988
3. Potten CS, Watson RJ, Williams GJ: Cell proliferation in the normal human breast. The effect of age and menstrual cycle upon proliferative activity of the normal human breast. Br J Cancer 58: 163-170, 1988
4. Ferenczy A, Bertrand G, Gelfand MM: Biopsy studies of the proliferation of human endometrium. Am J Obstet Gynecol 133: 859-867, 1979
5. Laidlaw IJ, Clarke R, Anderson E, Owen AWMC, Potten CS, Howell A: The proliferation of normal human breast tissue in nude mice is stimulated by oestrogen and not progesterone. In: Mansel RE (ed) Recent Developments in the Study of Benign Breast Disease. Proc 4th Int Benign Breast Symposium, 1993, pp 131-142
6. Battersby S, Anderson TJ, King RJB, McPherson K: Functional measures of cyclical changes. In: Mansel RE (ed) Recent Developments in the Study of Benign Breast Disease. Proc 4th Int Benign Breast Symposium, 1993, pp 143-148
7. Soule HD, McGrath CM: Estrogen responsive proliferation of clonal human breast carcinoma cells in athymic mice. Cancer Lett 10: 177-189, 1980
8. Osborne CK, Hobbs K, Clark GM: Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Res 45: 584-590, 1985
9. Lippman ME, Bolan G, Huff K: The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term culture. Cancer Res 36: 4610-4618, 1976
10. Lippman ME, Bolan G, Monaco ME, Pinkus L, Engel E: Model systems for the study of estrogen action in tissue culture. J Steroid Biochem 7: 1045-1051, 1976
11. Aitken SC, Lippman ME: Effect of estrogens and antiestrogens on growth-regulatory enzymes in human breast cancer cells in tissue culture. Cancer Res 45: 1611-1620, 1985
12. Katzenellenbogen BS, Kendra KL, Norman MJ, Berthois Y: Proliferation, hormonal responsiveness and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens. Cancer Res 47: 4355-4360, 1987
13. Ballare C, Bravo AI, Laucella S, Sorin I, Cerdeiro R, Loza J, Sousa Martinez F, Guman N, Mordoh J: DNA synthesis in estrogen receptor-positive human breast cancer takes place preferentially in estrogen receptor negative cells. Cancer 64: 842-848, 1989
14. Ballare C, Bravo AI, Sorin I, Guman N, Schiaffi JA, Yomha R, Bagnati A, Lema B, Mordoh J: The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer. Cancer 67: 1352-1358, 1991
15. Sahin AA, Ro JY, Bruner JM: Morphologic assessment of tumor proliferative fraction. Cancer Bull 45: 37-43, 1993
16. Derenzini M, Trerè D: Importance of interphase nucleolar organizer regions in tumor pathology. Virchows Archiv B Cell Pathol 61: 1-8, 1991
17. Ciocca DR, Stati AO, Amprino de Castro M: Colocalization of estrogen and progesterone receptors with an estrogen regulated heat shock protein in paraffin sections of human breast and endometrial cancer tissue. Breast Cancer Res Treat 16: 243-251, 1990
18. Elias JM, Margiotta M, Gaborc BS: Sensitivity and detection efficiency of the peroxidase antiperoxidase (PAP), avidin-biotin peroxidase complex (ABC), and peroxidase-labeled avidin-biotin (LAB) methods. Am J Clin Pathol 92: 62-67, 1989
19. Millert RT, Hapke MR, Greene GL: Immunocytochemical assay for estrogen receptor with monoclonal antibody D75 3P-gamma in routinely processed formaldehyde-fixed breast tissue. Comparison with frozen section assay and with monoclonal antibody-H222. Cancer 71: 3541-3546, 1993
20. Al Saati T, Clamens S, Cohen-Knafo E, Faye JC, Prats H, Coindre JM, Wafflart J, Caverivière P, Bayard F, Delsol G. Production of monoclonal antibodies to human estrogen-receptor protein (ER) using recombinant ER (RER). Int J Cancer 55: 651-654, 1993
21. Press MF, Greene GL: Localization of progesterone receptor with monoclonal antibodies to the human progestin receptor. Endocrinology 122: 1165-1175, 1988
22. Wolf HK, Dittrich KL: Detection of proliferating cell nuclear antigen in diagnostic histopathology. J Histochem Cytochem 40: 1269-1273, 1992
23. Shi S-R, Key ME, Kalra KL: Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 33: 741-748, 1991
24. Elledge RM, Ciocca DR, Langone GHT, McGuire WL: Estrogen receptor, progesterone receptor, and HER-2/neu protein in breast cancers from pregnant patients. Cancer 71: 2499-2506, 1993
25. Trerè D, Farabegoli F, Cancellieri A, Ceccarelli C, Eusebi V, Derenzini M: AgNOR area in interphase nuclei of human tumors correlates with the proliferative activity evaluated by bromodeoxyuridine labelling and Ki67 immunostaining. J Pathol 165: 53-59, 1991
26. Vargas-Roig LM, Lotfi H, Olcese JE, Lo Castro G, Ciocca DR: Effects of short-term tamoxifen administration in patients with invasive cervical carcinoma. Anticancer Res 13: 2457-2464, 1993
27. Allred DC, Clark GM, Elledge R, Fuqua SAW, Brown RW, Chamness GC, Osborne CK, McGuire WL: Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst 85: 200-206, 1993
28. Ciocca DR, Vargas-Roig LM: Estrogen receptor in human nontarget tissues: biological and clinical implications. Endocrine Rev 16: 35-62, 1995
29. Thomas T, Thomas TJ: Regulation of cyclin B1 by estradiol and polyamines in MCF-7 breast cancer cells. Cancer Res 54: 1077-1084, 1994
30. Daniel CW, Silberstein GB: Local effects of growth factors. In: Lippman ME, Dickson RB (eds) Breast Cancer: Cellular and Molecular Biology. Kluwer Academic Publishers, Norwell, MA, 1989, pp 79-92
31. Fernig DG, Smith JA, Rudland PS: Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland. In: Lippman ME, Dickson RB (eds) Regulatory Mechanisms in Breast Cancer: Advances in Cellular and Molecular Biology of Breast Cancer. Kluwer Academic Publishers, Boston, 1991, pp 47-78
32. Truss M, Beato M: Steroid hormone receptors: interactions with deoxyribonucleic acid and transcription factors. Endocrine Rev 14: 459-479, 1993
33. Jakesz R, Smith CA, Aitken S, Huff K, Schuette W, Shackney S, Lippman M: Influence of cell proliferation and cell cycle phase on expression of estrogen receptor in MCF-7 breast cancer cells. Cancer Res 44: 619-625, 1984
34. Silvestrini R, Daidone MG, Di Fronzo G: Relationship between proliferative activity and estrogen receptors in breast cancer. Cancer 44: 665-670, 1979
35. Marchetti E, Querzoli P, Marzola A, Bagni A, Ferretti S, Fabris G, Nenci I: Assessment of proliferative rate of breast cancer by Ki67 monoclonal antibody. Mod Pathol 3: 31-35, 1990
36. Campani D, Sarnelli R, Fontanini G, Martini L, Cecchetti D, De Luca F, Squartini F: Receptor status, proliferating activity, and c-erbB2 oncoprotein. An immunocytochemical evaluation in breast cancer. Annals New York Academy of Sciences 698: 167-173, 1993
37. Nicholson RI, Bouzubar N, Walker KJ, McClelland R, Dixon AR, Robertson JFR, Ellis IO, Blarney RW: Hormone sensitivity in breast cancer: influence of heterogeneity of oestrogen receptor expression and cell proliferation. Eur J Cancer 27: 908-913, 1991
38. Kunishio K, Ohmoto T, Matsuhisa T, Maeshiro T, Furuta T, Matsumoto K: The significance of nucleolar organizer region (AgNOR) score in predicting meningioma recurrence. Cancer 73: 2200-2205, 1994
39. Nakamura S, Takeda Y, Okabe Y, Yoshida T, Ohtake S, Kobayashi K, Kanno M, Matsuda T: Argyrophilic proteins of the nucleolar organizer region in acute leukemias and its relation to the S-phase fraction of leukemic cells. Acta Haematol 87: 6, 1992
40. Dietrich DR: Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker for cell proliferation. Crit Rev Toxicol 23: 77-109, 1993
41. Hall PA, Levison DA, Woods AI, Yu CC-W, Kellock DB, Watkins JA, Barnes DM, Gillet CE, Camplejohn R, Dover R, Wassern NH, Lane DP: Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 162: 285-294, 1990
42. Scott RJ, Hall PA, Haldane JS, van Noorden S, Price Y, Lane DP, Wright NA: A comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fraction. J Pathol 165: 173-178, 1991
43. Aaltomaa S, Lipponen P, Syrjanen K: Proliferating cell nuclear antigen (PCNA) immunolabeling as a prognostic factor in axillary lymph node negative breast cancer. Anticancer Res 13: 533-538, 1993
44. Peyrat JP, Bonneterre J, Vennin PH, Jammes H, Beuscart R, Hecquet B, Djiane J, Lefebvre J, Demaille A: Insulin-like growth factor 1 receptors (IGF1-R) and IGF1 in human breast tumors. J Steroid Biochem Molec Biol 37: 823-827, 1990
45. Ullrich SJ, Anderson CW, Mercer WE, Appella E: The p53 tumor suppressor protein, a modulator of cell proliferation. J Biol Chem 267: 15259-15262, 1992
46. Daniel CW, Silberstein GB, van Horn K, Strickland P, Robinson S: TGF-beta-1-induced inhibition of mouse mammary ductal growth: developmental specificity and characterization. Dev Biol 135: 20-30, 1989
47. Haslam SZ: Progesterone effects on deoxyribonucleic acid synthesis in normal mouse mammary glands. Endocrinology 122: 464-470, 1988
48. Clarke CL, Sutherland RL: Progestin regulation of cellular proliferation. Endocrine Rev 11: 96-131, 1990
49. Kalkhoven E, Kwakkenbos-Isbrücker L, De Laat SW, Van der Saag PT, Van der Burg B: Synthetic progestins induce proliferation of breast tumor cell lines via the progesterone or estrogen receptor. Mol Cell Endocrinol 102: 45-52, 1994
50. Vollmer G, Gerdes J, Knuppen R: Relationship of cytosolic estrogen and progesterone receptor content and the growth fraction in human mammary carcinomas. Cancer Res 49: 4011-4014, 1989
51. Musgrove EA, Lee CSL, Sutherland RL: Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor α, epidermal growth factor receptor, c-fos, and c-myc genes. Mol Cell Biol 11: 5032-5043, 1991
52. Wong MSJ, Murphy LC: Differential regulation of c-myc by progestins and antiestrogens in T-47D human breast cancer cells. J Steroid Biochem Mol Biol 39: 39-44, 1991
53. Musgrove EA, Hamilton JA, Lee CSL, Sweeney KJE, Watts CKW, Sutherland RL: Growth factor, steroid and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression. Mol Cell Biol 13: 3577-3587, 1993
54. Murphy LC, Murphy LJ, Dubik D, Bell GI, Shiu RPC: Expression of the gene encoding epidermal growth factor in human breast cancer cells. Regulation by progestins. Cancer Res 48: 4555-4560, 1988
55. Murphy LC, Dotzlaw H: Regulation of transforming growth factor-alpha and transforming growth factor-beta mRNA abundance in T-47D, human breast cancer cells. Mol Endocrinol 3: 611-617, 1989
56. Stampfer MR, Yaswen P: Factors influencing growth and differentiation of normal and transformed human mammary epithelial cells in culture. In: Milo GE, Casto BL, Schuler CF (eds) Transformation of Human Epithelial Cells: Molecular and Oncogenic Mechanisms. CRC Press, Boca Raton, 1992, pp 117-140
57. McGuire WL, Chamness GC, Fuqua SAW: Estrogen receptor variants in clinical breast cancer. Mol Endocrinol 5: 1571-1577, 1991
58. Sluyser M: Role of estrogen receptor variants in the development of hormone resistance in breast cancer. Clin Biochem 25: 407-414, 1992
59. Pfeffer U, Fecarotta E, Castagnetta L, Vidali G: Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer lines. Cancer Res 53: 741-743, 1993