A Convenient Multigram Scale Synthesis of Tetrahydrothiophene-3-one-1,1-dioxide

Synthetic Communications

Volumn 34, Issue 4, 2004, Pages 567-570

  Altenbach, Robert J ^a   Kalvoda, Ladislav ^b   Carroll, William A ^a  

^a ABBOTT LABORATORIES   (United States)

^b SYNLAB ACADEMY   (Germany)

Author keywords

Molescale two pot synthesis; Sulfone; Tetrahydrothiophene 3 one 1,1 dioxide

Indexed keywords

TETRAHYDROTHIOPHEN 3 ONE 1,1 DIOXIDE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; MELTING POINT; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SYNTHESIS;

EID: 1542635999     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120027703     Document Type: Article

References (4)

1. Belletire, J.L.; Spletzer, E.G. 3-Oxotetrahydrothiophene-1,1-dioxoide a versatile synthetic intermediate. Synth. Commun. 1983, 13 (4), 269-272.
2. Dodd, J.H.; Schwender, C.F.; Gray-Nunez, Y. Synthesis of novel cyclic sulfone dihydropyridines facilitated by a selective ethyl diazoacetate ring expansion. J. Heterocycl. Chem. 1990, 27 (5), 1453-1456.
3. Miklos, P.; Senning, A. Synthesis and equilibrium studies of new dihydrothiophene sulfoxides. Tetrahedron 1987, 43 (1), 249-254.
4. Leonard, N.J.; Figueras, J. Rearrangement of α-thiaketones during clemmensen reduction. J. Am. Chem. Soc. 1952, 74 (4), 917-920.