Arrhythmogenic Right Ventricular Cardiomyopathy Causing Sudden Cardiac Death in Boxer Dogs: A New Animal Model of Human Disease

Circulation

Volumn 109, Issue 9, 2004, Pages 1180-1185

  Basso, Cristina ^a   Fox, Philip R ^b   Meurs, Kathryn M ^c   Towbin, Jeffrey A ^d   Spier, Alan W ^c   Calabrese, Fiorella ^a   Maron, Barry J ^e   Thiene, Gaetano ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b ANIMAL MEDICAL CENTER   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e MINNEAPOLIS HEART INSTITUTE FOUNDATION   (United States)

Author keywords

Cardiomyopathy; Death, sudden; Models, animal; Pathology

Indexed keywords

ADIPOSE TISSUE; ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENIC HEART RIGHT VENTRICLE HYPERTROPHY; ARTICLE; BREED; CONTROLLED STUDY; DISEASE ASSOCIATION; DOG; FEMALE; HEART FAILURE; HEART MUSCLE; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE ARRHYTHMIA; HISTOPATHOLOGY; MALE; MYOCARDITIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SUDDEN DEATH; SYNCOPE;

ANIMALS; APOPTOSIS; ARRHYTHMIA; ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA; DEATH, SUDDEN, CARDIAC; DISEASE MODELS, ANIMAL; DOGS; ELECTROCARDIOGRAPHY; FEMALE; MALE; MYOCARDITIS; MYOCARDIUM;

EID: 1542619239     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000118494.07530.65     Document Type: Article

References (27)

1. Thiene G, Nava A, Corrado D, et al. Right ventricular cardiomyopathy and sudden death in young people. N Engl J Med. 1988;318:129-133.
2. Fontaine G, Fontaliran F, Frank R. Arrhythmogenic right ventricular cardiomyopathies: clinical forms and main differential diagnoses. Circulation. 1998;97:1532-1535.
3. Richardson P, McKenna W, Bristow M, et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation. 1996;93:841-842.
4. Tiso N, Stephan DA, Nava A. et al. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Hum Mol Genet. 2001;10:189-194.
5. Rampazzo A, Nava A, Malacrida S, et al. Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet. 2002;71:1200-1206.
6. Harpster NK. Boxer cardiomyopathy. In: Kirk RW, ed. Current Veterinary Therapy VIII Small Animal Practice. Philadelphia, Pa: WB Saunders; 1983:329-337.
7. Meurs KM, Spier AW, Miller MW. et al. Familial ventricular arrhythmias in boxers. J Vet Intern Med. 1999;13:437-439.
8. Breen M, Jouquand S, Renier C, et al. Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiationhybrid/ linkage map of the domestic dog genome to all chromosomes. Genome Res. 2001;11:1784-1795.
9. Meurs KM, Spier AW, Wright NA, et al. Comparison of in-hospital versus 24-hour ambulatory electrocardiography for detection of ventricular premature complexes in mature boxers. J Am Vet Med Assoc. 2001;218:222-224.
10. Kraus MS, Moïse NS, Rishniw M, et al. Morphology of ventricular arrhythmias in the boxer described by 12-lead electrocardiography with pace mapping comparison. J Vet Int Med. 2002;16:153-158.
11. Basso C, Thiene G, Corrado D, et al. Arrhythmogenic right ventricular cardiomyopathy: dysplasia, dystrophy, or myocarditis? Circulation. 1996;94:983-991.
12. Fox PR, Maron BJ, Basso C, et al. Spontaneous occurrence of arrhythmogenic right ventricular cardiomyopathy in the domestic cat: a new animal model of human disease. Circulation. 2000;102:1863-1870.
13. Maisch B, Hufnagel G, Schonian U, et al. The European study of epidemiology and treatment of cardiac inflammatory disease. Eur Heart J. 1995;16(suppl O):173-175.
14. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
15. Valente M, Calabrese F, Thiene G, et al. In vivo evidence of apoptosis in arrhythmogenic right ventricular cardiomyopathy. Am J Pathol. 1998;152:479-484.
16. Thiene G, Basso C. Arrhythmogenic right ventricular cardiomyopathy: an update. Cardiovasc Pathol. 2001;10:109-117.
17. Fox PR, Liu S-K, Maron BJ. Echocardiographic assessment of spontaneously occurring feline hypertrophic cardiomyopathy: an animal model of human disease. Circulation. 1995;92:2645-2651.
18. Kittleson MD, Meurs KM, Munro MJ, et al. Familial hypertrophic cardiomyopathy in Maine coon cats: an animal model of human disease. Circulation. 1999;99:3172-3180.
19. Moise NS, Meyers-Wallen V, Flahive WJ, et al. Inherited ventricular arrhythmias and sudden death in German shepherd dogs. J Am Coll Cardiol. 1994;24:233-243.
20. Calvert CA, Hall G, Jacobs G, et al. Clinical and pathologic findings in Doberman pinschers with occult cardiomyopathy that died suddenly or developed congestive heart failure: 54 cases (1984-1991). J Am Vet Med Assoc. 1997;210:505-511.
21. Nava A, Rossi L, Thiene G, eds. Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia. Amsterdam, the Netherlands: Elsevier; 1997.
22. Boffa GM, Thiene G, Nava A, et al. Cardiomyopathy: a necessary revision of the WHO classification. Int J Cardiol. 1991;30:1-7.
23. Yamamoto S, Tsyplenkova VG, James TN. Morphological pattern of death by myocytes in arrhythmogenic right ventricular dysplasia. Am J Med Sci. 2000;320:310-319.
24. Burke AP, Farb A, Tashko G, et al. Arrhythmogenic right ventricular cardiomyopathy and fatty replacement of the right ventricular myocardium: are they different diseases? Circulation. 1998;97:1571-1580.
25. Fontaliran F, Fontaine G, Fillette F, et al. Nosologic frontiers of arrhythmogenic dysplasia: quantitative variations of normal adipose tissue of the right heart ventricle. Arch Mal Coeur Vaiss. 1991;84:33-38.
26. d'Amati G, Leone O, di Gioia CR, et al. Arrhythmogenic right ventricular cardiomyopathy: clinicopathologic correlation based on a revised definition of pathologic patterns. Hum Pathol. 2001;32:1078-1086.
27. Nava A, Bauce B, Basso C, et al. Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol. 2000;36:2226-2233.