Proteomic Analysis of Cellular Responses to Low Concentration N-Methyl-N′-Nitro-N-Nitrosoguanidine in Human Amnion FL Cells

Environmental and Molecular Mutagenesis

Volumn 43, Issue 2, 2004, Pages 93-99

  Jin, Jinghua ^a   Yang, Jun ^a   Gao, Zhihua ^a   Yu, Yingnian ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cellular response; Mass spectrometry; N methyl N nitro N nitrosoguanidine; Proteomics; Two dimensional gel electrophoresis

Indexed keywords

ALKYLATING AGENT; BIOLOGICAL MARKER; CYTOSKELETON PROTEIN; METHYLNITRONITROSOGUANIDINE; PROTEIN; PROTEOME; REGULATOR PROTEIN; ZINC FINGER PROTEIN;

AMNION CELL; ARTICLE; DOWN REGULATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PROTEIN EXPRESSION; PROTEOMICS; SIGNAL TRANSDUCTION; TWO DIMENSIONAL GEL ELECTROPHORESIS;

AMNION; CELL LINE; DATABASES, PROTEIN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; METHYLNITRONITROSOGUANIDINE; PROTEIN BIOSYNTHESIS; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 1542618494     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.20001     Document Type: Article

References (27)

1. Agata Y, Matsuda E, Shimizu A, 1998. Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc finger proteins by degenerate PCR. Gene 213:55-64.
2. Amundson SA, Bitmer M, Chen Y, Trent J, Meltzer P, Fornace AJ Jr. 1999. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18:3666-3672.
3. Burnatowska-Hledin M, Lazdins IB, Listenberger L, Zhao P, Sharangpani A, Folta V, Card B. 1999. VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule. Am J Physiol 276:F199-209.
4. Burnatowska-Hledin M, Zhao P, Capps B, Poel A, Parmelee K, Mungall C, Sharangpani A, Listenberger L. 2000. VACM-1, a cullin gene family member, regulates cellular signaling. Am J Physiol Cell Physiol 279:C266-273.
5. Byrd PJ, Stankovic T, McConville CM, Smith AD, Cooper PR, Taylor AM. 1997. Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. Genome Res 7:71-75.
6. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M. 1999. Identification of a family of human F-box proteins. Curr Biol 9:1177-1179.
7. Dang DT, Pevsner J, Yang VW. 2000. The biology of the mammalian Kruppel-like family of transcription factors. Int J Biochem Cell Biol 32:1103-1121.
8. De la Ragione F, Borriello A, Mastropietro S, Della Pietra V, Monno F, Gabutti V, Locatelli F, Bonsi L, Bagnara GP, Iolascon A. 1997. Expression of G1-phase cell cycle genes during hematopoietic lineage. Biochem Biophys Res Commun 231:73-76.
9. Ekholm SV, Reed SI. 2000. Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle. Curr Opin Cell Biol 12:676-684.
10. Guo YL, Chang HC, Tsai JH, Huang JC, Li C, Young KC, Wu LW, Lai MD, Liu HS, Huang W. 2002. Two UVC-induced stress response pathways in HeLa cells identified by cDNA microarray. Environ Mol Mutagen 40:122-128.
11. Hu W, Yu Y, Chen X, Song T, Xie H. 1999. Isolating the cDNA fragment inhibiting nontargeted mutagenesis in Vero cell by antisense technology. Chin Sci Bull 44:533-537.
12. Ilyin GP, Rialland M, Glaise D, Guguen-Guillouzo C. 1999. Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. FEBS Lett 459:75-79.
13. Imanishi M, Hori Y, Nagaoka M, Sugiura Y. 2001. Design of novel zinc finger proteins: towards artificial control of specific gene expression. Eur J Pharm Sci 13:91-97.
14. Jelinsky SA, Samson LD. 1999. Global response of Saccharomyces cerevisiae to an alkylating agent. Proc Natl Acad Sci USA 96:1486-1491.
15. Jin J, Gao Z, Yang J, Guo L, Yu Y. 2003. Altered expression of zinc finger proteins, ADAMs, and integrin-related proteins following treatment of cultured human cells with a low concentration of N-methyl-N'-nitro-N-nitrosoguanidine. Environ Mol Mutagen 41:344-352.
16. Jinno S, Hung SC, Yamamoto H, Lin J, Nagata A, Okayama H. 1999. Oncogenic stimulation recruits cyclin-dependent kinase in the cell cycle start in rat fibroblast. Proc Natl Acad Sci USA 96:13197-13202.
17. Klug A, Schwabe JW. 1995. Protein motifs 5. Zinc fingers. FASEB J 9:597-604.
18. Laity JH, Lee BM, Wright PE. 2001. Zinc finger proteins: new insights into structural and functional diversity. Curr Opin Struct Biol 11:39-46.
19. Lu J, Yu Y, Xie H. 2000. Activation of JNK/SAPK pathway in vero cells induced by N-methyl-N'-nitro-N-nitrosoguanidine. Chin J Pathophysiol 16:481-485.
20. Medugno L, Costanzo P, Lupo A, Monti M, Florio F, Pucci P, Izzo P. 2003. A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inbibits gene expression. FEBS Lett 534:93-100.
21. Meyer RG, Kupper JH, Kandolf R, Rodemann HP. 2002. Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro. Eur J Biochem 269:337-346.
22. Meyerson M, Harlow E. 1994. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol 14:2077-2086.
23. Parra M, Lluis F, Miralles F, Caelles C, Munoz-Canoves P. 2000. The cJun N-terminal kinase (JNK) signaling pathway mediates induction of urokinase-type plasminogen activator (uPA) by the alkylating agent MNNG. Blood 96:1415-1424.
24. Wang G, Yu Y, Chen X, Xie H. 2001. Low concentration N-methyl-N'-nitro-N-nitrosoguanidine activates DNA polymerase-beta expression via cyclic-AMP-protein kinase A-cAMP response element binding protein pathway. Mutat Res 478:177-184.
25. Wang Z, Wang G, Yang J, Guo L, Yu Y. 2003. Activation of protein kinase A and clustering of surface receptors induced by N-methyl-N'-nitro-N-nitrosoguanidine is independent of genomic DNA damage. Mutat Res 528 29-36.
26. Yu Z, Ford BN, Glickman BW. 2000. Identification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays. Environ Mol Mutagen 36:201-205.
27. Zhang X, Yu Y, Chen X. 1994. Evidence for nontargeted mutagenesis in a monkey kidney cell line and analysis of its sequence specificity using a shuttle-vector plasmid. Mutat Res 323:105-112.