Altered bupivacaine pharmacokinetics by MgSO4 in rats [8]

Canadian Journal of Anesthesia

Volumn 51, Issue 1, 2004, Pages 93-94

  Okutomi, Toshiyuki ^a   Saito, Miwaka ^a   Matsumoto, Yoshiaki ^a   Shimizu, Makiko ^a   Fukuoka, Masamichi ^a   Hoka, Sumio ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

3' HYDROXYBUPIVACAINE; AMITRIPTYLINE; BUPIVACAINE; CARBAMAZEPINE; CYTOCHROME P450; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; DIAZEPAM; DRUG METABOLITE; MAGNESIUM SULFATE; MIDAZOLAM; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; BOLUS INJECTION; CATHETERIZATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG ELIMINATION; DRUG INHIBITION; DRUG METABOLISM; EXPERIMENTAL DESIGN; LETTER; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SEIZURE;

EID: 1542604154     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03018565     Document Type: Letter

References (5)

1. Okutomi T, Zhang Y, Cooper TB, Morishima HO. The effect of MgSO4 on bupivacaine-induced convulsions in nonpregnant and pregnant rats. Anesth Analg 2001; 92: S220.
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3. Ueng YF, Kuwabara T, Chun YJ, Guengerich FP. Cooperativity in oxidations catalyzed by cytochrome P450 3A4. Biochemistry 1997; 36: 370-81.
4. Yamazaki H, Ueng YF, Shimada T, Guengerich FP. Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH - cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates. Biochemistry 1995; 34: 8380-9.
5. Maenpaa J, Hall SD, Ring BJ, Strom SC, Wrighton SA. Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: The effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone. Pharmacogenetics 1998; 8: 137-55.