Circulating cell-free fetal DNA in maternal serum appears to originate from cyto- and syncytio-trophoblastic cells. Case report

Human Reproduction

Volumn 19, Issue 3, 2004, Pages 723-724

  Flori, E ^a   Doray, B ^a   Gautier, E ^b   Kohler, M ^c   Ernault, P ^b   Flori, J ^c   Costa, Jean Marc ^b  

^a HÔPITAL DE HAUTEPIERRE   (France)

^b AMERICAN HOSPITAL OF PARIS   (France)

^c SIHCUS CMCO Centre Medico Chirurgical et Obstetrical   (France)

Author keywords

Case report; Fetal DNA; Maternal serum; Trophoblastic cells

Indexed keywords

DNA;

ARTICLE; CHROMOSOME YP; CONTROLLED STUDY; CYTOTROPHOBLAST; DIAGNOSTIC ACCURACY; FEMALE; FETUS; FETUS CELL; FETUS ECHOGRAPHY; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; KARYOTYPE 45,X; MALE GENITAL SYSTEM; MATERNAL BLOOD; PRENATAL DIAGNOSIS; SEX DIAGNOSIS; SRY GENE; SYNCYTIOTROPHOBLAST;

EID: 1542501831     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deh117     Document Type: Article

References (6)

1. Costa JM, Benachi A, Gautier E, Jouannic JM, Ernault P and Dumez Y (2001) First-trimester fetal sex determination in maternal serum using real-time PCR. Prenat Diagn21, 1070-1074.
2. Costa JM, Benachi A and Gautier E (2002) New strategy for prenatal diagnosis of X-linked disorders. N Eng J Med 346,1502.
3. Guibert J, Benachi A, Grebille AG, Ernault P, Zorn JR and Costa JM (2003) Kinetics of SRY gene appearance in maternal serum: detection by real-time PCR in early pregnancy after assisted reproductive technique. Hum Reprod 18,1733-1736.
4. Kalousek DK, Barrett IJ and Gärtner AB (1992) Spontaneous abortion and confined chromosomal mosacisim. Hum Genet 88,642-646.
5. Lo YM, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW and Wainscot JS (1997) Presence of fetal DNA in maternal plasma and serum. Lancet 350,485-487.
6. Zhong X., Holzgreve W and Hahn S (2002) Cell-free fetal DNA in the maternal circulation does not stem from the transplacental passage of fetal erythroblasts. Mol Hum Reprod 8,864-870.